Detection of the rare PGM1(3) allele. Further biochemical and genetic characterization of the PGM1(3) isozymes

A family possessing the rare PGM1(3) allele has been found in North Carolina, and criteria for the electrophoretic separation and accurate typing of the PGM1(3) isozymes are outlined. The PGM1(3) isozymes detected proved to be useful in helping to determine parentage in an incest investigation. The pattern of segregation of the PGM1(3) allele in four generations of this family and thermostability studies on the PGM1(3) isozymes are presented.     

English court upholds ban on newspaper publishing identity of HIV-positive health-care worker

In the last issue of the Review, we reported about an HIV-positive health-care worker in the UK who brought legal proceedings to prevent the National Health Service from notifying his previous patients that he is infected. In February 2002, the Court of Appeal for England and Wales (Civil Division) upheld a ban on publishing his name and that of the health authority for which he worked.     

HIV-positive child made ward of court after father refuses treatment with antiretroviral drugs

In 1999, we reported a number of cases in Canada, the US, and the UK in which child-welfare authorities have disputed parents' decisions to refuse HIV testing or treatment for their children. This article reports on new developments in one of those cases. On 10 May 2002, the English High Court heard submissions regarding the future of a three- year-old HIV-positive girl who was made a ward of the court after her father refused to allow her to be treated with antiretroviral drugs.     

Blood or blood products: Minister's decision to deny application to Extraordinary Assistance Plan upheld

In April 2002, the Federal Court of Canada decided the federal Minister of Health does not have the authority to award compensation under the Extraordinary Assistance Plan unless an independent medical review board finds that the applicant was infected with HIV as a result of the receipt of blood or blood products in Canada between 1978 and 1989.     

Detection of a primer-binding site polymorphism for the STR locus D16S539 using the Powerplex 1.1 system and validation of a degenerate primer to correct for the polymorphism

Quality assurance samples submitted from the NCSBI as part of a contract with TBTG to outsource DNA Database samples showed unexpected discrepancies for the locus D16S539 when all other loci yielded identical results. Discrepancies observed included allele drop out and an imbalance in sister alleles with samples returned from TBTG. This led to a comprehensive review of the technical procedures used between the two laboratories to determine the cause of the discrepancies noted for the locus D16S539, since both laboratories were using the PowerPlex 1.1 typing kit from the Promega Corporation. The NCSBI and the TBTG utilize different extraction methods (organic extraction vs. FTA) and amplification conditions (AmpliTaq vs AmpliTaq Gold), respectively, so the exact cause of discrepancy observed was not immediately apparent. Experiments at the NCSBI associated the observed allele drop out and the imbalance of the sister alleles with the use of AmpliTaq Gold and a hot start procedure. Sequencing data revealed that a point mutation resides on the D16S539 primer-binding site that reaches polymorphic levels in African-American populations. This led to the development of a degenerate primer by the Promega Corporation to detect "missing" alleles when AmpliTaq Gold is used. The degenerate primer was then thoroughly tested to show its efficacy in detecting the "true" D16S539 profile when used.     

The Development of Stereotypes About the Rich and Poor: Age,Race, and Family Income Differences in Beliefs

African American and European American 4th, 6th, and 8th graders rated the competence of rich and poor children in academics (i.e., math, science, reading, writing, school grades, smartness), sports, and music. In contrast to middle school students, 4th graders favored the rich in all 3 domains. Youth of both races reported that the rich were more competent in academics than the poor; these beliefs were especially pronounced among Black youth. White, older, and more affluent students favored the poor in sports, whereas their counterparts either favored the rich or were egalitarian. No interactions were found between grade and race or grade and family income. The implications of these beliefs for policy and identity development theory are discussed. Doctoral student at the University of North Carolina, Chapel Hill. Research interests include the influence of race identity, race socialization, and stereotypes on the academic achievement of African American youth. Associate Professor at the University of North Carolina, Chapel Hill. Received Ph.D. in Psychology at the University of Notre Dame. Her research specialty is the development of children's achievement-related beliefs. Assistant Professor at the University of Michigan. Received Ph.D. from the University of Virginia. Research interests include predictors of academic self-views in children and adolescents.     

The Role of Religion in the Transition to Adulthood for Young Emerging Adults

Recent research has highlighted the role of culture in emerging adulthood (age between 18 and 25 years). However, most studies have examined majority cultures (e.g., China) as well as subcultures (e.g., American ethnic minorities). Thus, work on other aspects of culture such as religion is needed given the emerging evidence that it may have an impact on development. This study explored the role of religious culture in the emerging adulthood of college students. Participants were 445 undergraduates (ages 18–20 years) from institutions that were Catholic (31 males, 89 females), Mormon (48 males, 200 females), and public (21 males, 56 females). Results found religious differences in (a) the criteria young people deemed necessary for adulthood, (b) the extent to which emerging adults felt they had achieved these criteria, (c) various aspects of spirituality including practices and beliefs, and (d) the behaviors in which emerging adults engage.Portions of this study were presented at the biennial meeting of the Society for Research in Adolescence, Baltimore, Maryland, in March 2004.Assistant Professor of Psychology at Loyola College in Maryland. She received her PhD in 2001 from the University of Maryland, College Park. Her major research interests are in social-and self-development during adolescence and emerging adulthood.Assistant Professor of Marriage, Family, and Human Development in the School of Family Life at Brigham Young University. He received his PhD in 2000 from the University of Maryland, College Park. His major research interests are in social-and self-development during early childhood and emerging adulthood.     

The Real Winner's Curse

Traditional theories of democracy suggest that political representation of excluded groups can reduce their incentives to engage in conflict and lead to lower violence. However, this argument ignores the response of established elites when (1) their interests are threatened by the policy stance of new political actors and (2) elites have a comparative advantage in the exercise of violence. Using a regression discontinuity approach, we show that the narrow election of previously excluded left‐wing parties to local executive office in Colombia results in a one standard deviation increase in violent events by right‐wing paramilitaries. We interpret this surge in violence as a reaction of traditional elites to offset the increase in outsiders' access to formal political power. Consistent with this interpretation, we find that violence by left‐wing guerrillas and other actors is unaffected and that violence is not influenced by the victory of right‐wing or other new parties in close elections.