Effect of storage temperature on endogenous GHB levels in urine

Because gamma-hydroxybutyrate (GHB) is an endogenous substance present in the body and is rapidly eliminated after ingestion, toxicologists investigating drug-facilitated sexual assault cases are often asked to differentiate between endogenous and exogenous levels of GHB in urine samples.This study was designed to determine the effects of storage temperature on endogenous GHB levels in urine. Specifically, it was designed to ascertain whether endogenous levels can be elevated to a range considered indicative of GHB ingestion.Urine specimens from two subjects that had not been administered exogenous GHB were collected during a 24h period and individually pooled. The pooled specimens were separated into standard sample cups and divided into three storage groups: room temperature ( approximately 25 degrees C), refrigerated (5 degrees C), and frozen (-10 degrees C). Additionally, some specimens were put through numerous freeze/thaw cycles to mimic situations that may occur if multiple laboratories analyze the same specimen. Periodic analysis of the samples revealed increases in the levels of endogenous GHB over a 6-month period. The greatest increase (up to 404%) was observed in the samples maintained at room temperature. The refrigerated specimens showed increases of 140-208%, while the frozen specimens showed smaller changes (88-116%). The specimens subjected to multiple freeze/thaw cycles mirrored specimens that had been thawed only once. None of the stored urine specimens demonstrated increases in GHB concentrations that would be consistent with exogenous GHB ingestion.     

关于刑事和解的几点看法

刑事犯罪多发背景下,被害人利益难以通过传统刑事诉讼程序获得有效救济,甚至存在被害人在刑事诉讼过程中二次受害的情形,从而引发一系列不稳定社会因素,与建设和谐社会的要求背道而驰。刑事和解正是在被害人保护思想的发展与犯罪人复归思想的兴起基础上产生的以恢复性司法为基本理念以构建和谐社会为终极目标的新型刑事案件解决制度。     

When Scientists Deceive: Applying the Federal Regulations

Deception is a useful methodological device for studying attitudes and behavior, but deceptive studies fail to fulfill the informed consent requirements in the U.S. federal regulations. This means that before they can be approved by Institutional Review Boards, they must satisfy the four regulatory conditions for a waiver or alteration of these requirements. To illustrate our interpretation, we apply the conditions to a recent study that used deception to show that subjects judged the same wine as more enjoyable when they believed it had a higher price.     

Student perceptions of hate crimes

Estimates indicate hate crimes are a growing concern in the United States. This paper addresses how criminal justice students perceive victims of hate crimes. Survey findings show subjects are less likely to define certain groups of people as victims of hate crimes. Suggestions are made as to how criminal justice departments can heighten awareness of hate crime victims, multiculturalism, and gender diversity among criminal justice students.