Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial

Early interventions are a preferred method for addressing behavioral problems in high‐risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10‐year‐long intervention to prevent high‐risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European‐American children, a variant of NR3C1 identified by the single‐nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African‐American children. We discuss implications for efforts to prevent externalizing problems in high‐risk children and for public policy in the genomic era.     

Truth and Justice, Inquiry and Advocacy, Science and Law

Abstract. There is tension between the adversarialism of the U.S. legal culture and the investigative procedures of the sciences, and between the law's concern for finality and the open‐ended fallibilism of science. A long history of attempts to domesticate scientific testimony by legal rules of admissibility has left federal judges with broad screening responsibilities; recent adaptations of adversarialism in the form of court‐appointed experts have been criticized as “inquisitorial,” even “undemocratic.” In exploring their benefits and disadvantages, it would make sense to look to the experience of other legal systems.     

Development and morphology of the sternal foramen

Bony defects (foramina) in the sternum were found in 6.7% of a large contemporary autopsy population. Usually solitary and located in the body of the sternum, these defects rarely occur multiply and in the manubrium. They have been found in children as young as 8 years as well as in persons of advanced age. Multiple mesosternal foramina and a manubrial foramen are described here for the first time. Sternal foramina form along lines of fusion of multiple centers of ossification and are the result of incomplete fusion. They have been misinterpreted as acquired lesions, usually gunshot wounds.     

The nature of the beneficiary's interest and the role of the personal representative in the administration and distribution of an estate

who at the time of writing this article was a part-time tutor at Cardiff Law School.     

Women's criminality,criminal women,criminalized women? Questions in and for a feminist perspective

Although the notion of taking gender into account in social analyses has been around for some time, for the large partit has not been taken seriously by criminologists. In this article, Laberge shows how the neglect of women's criminality has been to the detriment of criminological inquiry. Through an examination of the questions usually asked about women in contact with the penal system, the author takes us beyond an ‘additive’ approach to explaining crime. Reorganizing these questions, she outlines a number of analytical distinctions that will transform our understanding of criminalized women, specifically, and criminological inquiry, generally.     

The Citizen Makes an Entrée: Redefining the National Community in Quebec

This paper focuses on the well-orchestrated and much publicised project regarding the construction and implementation by the Quebec state of a citoyennetéquébécoise. This endeavour is viewed here as the most recent phase of a process of boundary definition that began with the Quiet Revolution in the early 1960s, and that proceeded from the cultural definition of an ethnic nation to a pluralist conception of the territory, and then from a pluralist definition of the community to the present elaboration of a specifically Québécois citizenship, which merges here with nationality. In spite of a shift from a cultural to a territorially based definition of the community, I argue that the citizenship presently developed is anchored in a homogenised notion of cultural belonging, as the Quebec state is attempting to define a 'universal' national identity that would subordinate all others. The national model of citizenship is preferred over the postnational, the republican over the pluralist, the undifferentiated over the differentiated, at least when it comes to cultural identity. Language is viewed as the bearer of a culture, but also as a common property and a threatened good that must be protected by all residents. This fosters the redefinition of a collective project that can include non-French Canadians and be less past-oriented than previously. Whether such a strategy will appear more palatable to non-French Canadians remains to be seen, in a context where the case for multicultural rights and differentiated postnational identities remains very strong on the international scene.     

Transformative state publics

Against the conventional assumption that publics, and particularly radical publics, are outside the state, this article explores their mutual combination and entanglement in order to consider how states might contribute to progressive politics. At the heart of this account is a concept of the state that incorporates the dissident and fleeting, and a conception of transformative publics based on four modalities: prefigurative, improper, liberatory, and unconditional. Transformative publics can be found within state formations; they also combine with them to produce new political governance relations. To develop this argument, the article focuses on two kinds of publics: those involving compelled state actors, such as school children and prisoners; and those, such as protest camps, taking shape through grass-roots political action.     

The Transportability of Contingency Management in Problem-solving Courts

Problem-solving (PS) courts continue to proliferate throughout the country, providing an ideal setting for understanding the factors affecting the use of rewards, a key part of one evidence-based practice (EBP), contingency management (CM). This study uses the concept of transportability to explore how justice practitioners implement CM. Based on roughly 400?h of ethnographic fieldwork, conducted over 34?months in six PS courts, we examine the implementation and adaptation of CM. While decisions to adopt and implement practices are concentrated at the managerial level of organizations, the implementation processes used by frontline workers provide key insight into how EBP may become an everyday workplace practice. This study finds frontline workers adapting CM principles to their environments. While it might appear as though CM implementation strays from the original evidence-based construct, local adaptations provide a foundation for understanding the factors that affect the transportability of CM into routine practice.     

Mass Reentry,Neighborhood Context and Recidivism: Examining How the Distribution of Parolees Within and Across Neighborhoods Impacts Recidivism

Recent scholarship focuses on the role neighborhood context plays in reoffending. These studies lack an examination of how the size of the parolee population at the neighborhood-level impacts individual recidivism. We examine how the size and clustering of parolee populations within and across neighborhoods impacts individual-level recidivism. Using data from parolees returning to three Ohio cities from 2000 to 2009, we examine how concentrations of parolees in neighborhoods and in the surrounding neighborhoods impact the likelihood of reoffending. We also examine whether parolee clustering conditions the relationship between neighborhood-level characteristics and recidivism. Results show concentrated reentry increases recidivism, while parolees in stable neighborhoods are less likely to recidivate. Also, the positive effect of parolee concentration is tempered when parolees return to stable neighborhoods. These findings suggest that augmenting resources available in neighborhoods saturated by parolees, as well as bolstering residential stability in these same neighborhoods might reduce reoffending.