Interaction of butorphanol, with monoamine oxidase inhibitor, tranylcypromine.

This investigation examines the possibility of interaction between tranylcypromine and butorphanol in comparison to pethidine. The LD50 of pethidine and butorphanol were determined in mice pretreated with the non-selective monoamine oxidase (MAO) inhibitor, tranylcypromine orally for 8 days or with oral saline solution. Tranylcypromine decreased the LD50 of both pethidine and butorphanol by 78% and 41%, respectively. Anesthetized rabbits with halothane pretreated with tranylcypromine or saline were given pethidine (5 mg/kg i.v.) or butorphanol (0.5, 1 and 2 mg/kg i.v.). Pethidine produced a marked increase in blood pressure in rabbits pretreated with tranylcypromine and did not affect significantly the heart rate. Butorphanol did not affect either blood pressure or heart rate at doses of 0.5 or 1 mg/kg. However, the largest dose of butorphanol (2 mg/kg) produced hypotension and tachycardia in rabbits pretreated with tranylcypromine. Neither pethidine nor butorphanol affected the temperature of anesthetized rabbits pretreated with tranylcypromine or saline.     

U.S. Supreme Court Affirms Potentially Responsible Parties' Right of Action for Cost Recovery

In the wake of the Supreme Court's decision in Aviall—that potentially responsible parties (PRPs) are not permitted to seek contribution from other PRPs under CERCLA unless they have been sued or otherwise settled their CERCLA liability—PRPs and the courts have struggled to identify a remedy for those that voluntarily undertake cleanup of contaminated sites. The Atlantic Research decision resolves a conflict among the circuits and clarifies that PRPs voluntarily incurring cleanup costs pursuant to CERCLA, can maintain an action for cost recovery against other PRPs. The authors discuss the current legal landscape regarding actions for cost recovery as presented in Atlantic Research.     

Managing Equality in Social Dilemmas: Emotional and Retributive Implications

The equality rule is an important coordination rule in symmetric public good dilemmas. Although prior research emphasized that people use the equality rule out of efficiency concerns (as it helps to obtain the public good in the most efficient manner among group members), it may also reflect a true preference for fairness. More precisely, research examining emotional and retributive reactions as a result of a violation of the equality rule by a fellow group member showed that equality indeed is related to people’s personal values and what they consider to be fair. The present paper suggests that a violation of the equality rule results in emotional reactions, and these emotional experiences encourage further retributive actions. The different reactions following an equality violation are described as a function of three features: (1) the motives to use equality, (2) attributions for explaining the violation, and (3) the honesty of the given explanation. The write-up of this paper was partly supported by GOA/05/04 from the Research Fund of the Katholieke Universiteit Leuven. The research and write-up was supported by a fellowship of the Netherlands Organization for Scientific Research (NWO, Grant No. 016.005.019), awarded to the second author.     

This is a man’s world ... or least that’s how it looks in the journals

Mainstream criminology still tends to focus on gender as a control variable, ignoring the different pathways to crime followed by males and females. This leaves us with knowledge that we already have—males commit more criminal and delinquent acts than do females, but little information about the similarities and differences between men and women who commit crimes. On the other hand, feminist approaches tend to do one of two things: deal with girls and women only or deal with women and men separately to illuminate the differences. In this paper, we examine articles in three major journals, Criminology, Justice Quarterly, and Journal of Research in Crime and Delinquency, to explore the ways that gender is treated in mainstream criminology journals. Then, we will discuss the implications this has for feminist criminology.     

Role of Culture and Context: Ethical Issues in Research with Asian Americans and Immigrants in Intimate Violence

Ethical principles are often presented as universal, immutable rules. However, when conducting research with ethnic minority groups, such as Asian Americans and immigrants, ethical issues need to be placed within a sociocultural context as ethical responses are filtered through the specific value orientations and belief systems of the ethnic group under study. Further, when the group is a marginalized population, power dynamics complicate ethical principles of autonomy. The complexities are further accentuated with sensitive topics such as intimate violence or domestic violence. Consequently, ethical questions about autonomy, informed consent, confidentiality, limits to confidentiality, and protecting participants’ safety and reducing distress need to be at the forefront when planning intimate violence research. An overview of sociocultural context of Western biomedical ethics is presented and specific ethical issues that emerge when conducting intimate violence are discussed.     

Institutionalizing ambiguity: the management review group and the reshaping of the defence policy process in Canada

Abstract: The Department of National Defence (dnd) and the Canadian Armed Forces (CF) have been the subject of many studies intended to elicit a better return from defence efforts. None of these studies have been at all comprehensive. The 1971 white paper, Defence in the 70s, introduced a new study aimed at “ensuring maximum effectiveness” in DND. The 1972 Management Review Group (MRC) report changed the entire administrative structure of DND and the CF, introduced new concepts for management, and shifted the power structure of the central bureaucracy. By the end of 1972, DND and the CF had a new set of principal actors, a new administrative structure, and a new policy process. To some the changes were more significant than previous unification reforms. The mrc report stands in sharp contrast to other studies because it has not been available to officials, scholars, or the public. Yet an awareness of die concepts that underlie the recommendations of the MRG is fundamental to understanding why the National Defence Headquarters exists and functions as it does today and why some issues are advanced over others. Sommaire: Le ministére de la Défense nationale (MDN) et les Forces armées cana-diennes (FC) ont fait l'objet de nombreuses “études” visant à accroître le rendement des efforts faits dans le domaine de la défense. Aucune de ces études n'est exhaustive. Le livre blanc de 1971, s'intitulant La défense dans les années 70, présentait une nouvelle étude dont l'objectif était “d'assurer une efficacité maximale” au sein du MDN. Le rapport de 1972 du Management Review Group (MRG) a modifyé toute la structure administrative du MDN et des FC, a introduit de nouveaux concepts de gestion et a entraîné un déplacement des pouvoirs de la bureaucratie centrale. Vers la fin de 1972, le MDN et les FC étaient dotés de nouveaux acteurs principaux, d'une nouvelle structure administrative et de nouvelles méthodes d'établissement de politique. Pour certains, ces changements ont été plus importants que les précédentes réformes d'unification. Contrairement aux autres études, le rapport du MRG n'a pas été mis à la disposition des responsables, des intellectuels ou du public. II est pourtant essentiel de con-naître les concepts sur lesquels s'appuient les recommandations du MRG si Ton veut comprendre pourquoi le Quartier général de la Défense nationale est ce qu'il est aujourd'hui, son mode de fonctionnement et les raisons pour lesquelles certaines questions ont pris le pas sur d'autres.