Long-term intracerebral inflammatory response after traumatic brain injury

Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.     

Mainstreaming: A case for optimism and cynicism

This paper seeks to evaluate the concept of mainstreaming against a range of feminist critiques of laws and legal systems and to examine the case for the pursuit of feminist politics through mainstreaming strategies. It begins, in section two, by identifying theme sin existing mainstreaming literature, and then in section three considers the potential of mainstreaming to tackle the causes o fine quality. In particular it questions whether mainstreaming can address the patriarchal nature of laws and legal systems and the essentialising tendencies of law, and whether mainstreaming can effectively tackle market-driven inequality. A final section considers the conditions under which feminists might consider engagement with mainstreaming and the limits of such strategies. This revised version was published online in July 2006 with corrections to the Cover Date.     

“A disagreement between allies”: The United Kingdom,the United States,and the Soviet-Japanese territorial dispute, 1945–1956

Russian-Japanese relations are frozen in time by their territorial dispute over the Kuril Islands. In untangling the dispute, scholars have studied the history of Russo-Japanese relations, the USSR’s annexation of the islands in 1945, and the role of the United States as the USSR’s erstwhile wartime ally and Japan’s postwar partner. The United Kingdom, a key player in 1945, has been neglected in these studies. This article analyzes the evolution of the British position on the Soviet-Japanese territorial dispute from 1945 to the establishment of diplomatic relations between the two countries in 1956. The article reveals the marked divergence in this position from that of the United States, proceeding from a disagreement over the interpretation of the 1945 Yalta Agreement. In addition, the article highlights the manipulation of the territorial dispute by the United States to further its own political and security objectives and the British reaction to these maneuvers. Her recent publications includeBack in the USSR: Russia’s Intervention in the Internal Affairs of the Former Soviet Republics and the Implications for United States Policy Toward Russia (with Pamela Jewett) (John F. Kennedy School of Government, 1994).