120例肝豆状核变性合并抑郁症状患者的中医证型及神经递质与炎症因子变化特点研究

目的观察肝豆状核变性合并抑郁症状患者的临床表现,研究该病的发病机制。方法对120例诊断为肝豆状核变性抑郁症状患者进行中医证候分型,观察汉密尔顿抑郁量表-24(Hamilton depression rating scale-24,HDRS-24)、抑郁自评量表(self-rating depression scale,SDS)、统一Wilson病评定量表(unified Wilson's disease rating scale,UWDRS)评分,检测5-羟色胺(5-hydroxytryptamine,5-HT)、多巴胺(dopamine,DA)、白细胞介素-4(interleukin-4,IL-4)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-10(interleukin-10,IL-10)含量,比较不同证型患者的量表评分和神经递质、炎症因子水平。结果120例患者较为多见的抑郁症状有抑郁情绪114例(95.0%)、工作和生活兴趣减退52例(43.3%)、全身躯体化症状26例(21.7%)、能力减退感83例(69.2%)、自卑感68例(56.7%),其他抑郁表现不多见。与脾肾阳虚证和湿热内蕴证患者比较,痰瘀互结证患者的HDRS-24、SDS、UWDRS评分更高(P<0.05);与湿热内蕴证患者相比,脾肾阳虚证抑郁症状多见(P<0.05);与脾肾阳虚证和湿热内蕴证患者比较,痰瘀互结证患者外周血5-HT、DA、IL-4、IL-10水平较低(P<0.05),IL-6水平较高(P<0.05)。脾肾阳虚证与湿热内蕴证患者上述指标比较,差异均有统计学意义(P<0.05)。结论肝豆状核变性抑郁症状发生可能与铜沉积脑部引起神经递质5-HT、DA和炎症因子IL-4、IL-6、IL-10水平变化有关,其中痰瘀互结证患者抑郁症状程度最重,原因可能为痰瘀更易影响体内5-HT、DA、IL-4、IL-6、IL-10水平。     

MARKET WATCH

By ordering another hike in the reserve requirement ratio,China strengthens efforts to combat inflation.Housing prices continue to creep up in tracked cities.Domestic enterprises look to expand beyond China’s bor-ders as reflected in the soaring outbound direct investment.The aviation sector loses steam as profits fall dramatically.China’s Internet giant Tencent sees its profit growth slow down.     

The Plan for 2012

<正>China aims to walk a fine line between maintaining stable growth, rebalancing the economy and combating inflation next year For the Chinese economy, 2012 will be a year filled with uncertainties. With the Western world struggling with a fragile recovery, China’s export growth has taken a hit, with expectations of even worse to come.     

MARKET WATCH

China widens the tax rebate program for Hainan Provinceto stimulate the island’s tourism industry.The banking sector fares well with profits surging last year.By imposing a higher resource tax on rare earth exploration,China tries to streamline the fragmented industry.The shipping giantCOSCO jumps back into the black thanks to buoyant market demands.The international consulting firm McKinsey&Co.expects China to replace Japan as the world’s top luxury goods market by 2015.     

MARKET WATCH

China slashes import duties on 33 items,a move expected to stimulate imports and benefit a series of relevant sectors.Growth of industrial profits is slowing down due to costs inflation and tightening monetary policies.Foreign banks operating in China see a rosy future for their businesses.Mounting debt poses risks to local governments.By closing 56 unlicensed express delivery firms,China aims to streamline the crowded and chaotic industry.Suning takes majority control of the Japanese company Laox as the Chinese appliance retailer expands abroad.     

MARKET WATCH

The manufacturing industry shows signs of recovery as reflected by a rebounding PMI. The initial public offerings market withers due to less than favorable stock markets. Chinese shipbuilders reel from decreasing orders as external demands falter. The mobile payment industry bursts with vitality, though the security issue remains an acute concern. Foreign banks in China lag behind their local competitors in terms of profitability owing to limited ability to attract deposits.     

Away to Anhui

<正>Central China’s Anhui Province becomes a major destination for industry as companies move their production lines inland Wage growth and land costs inflation are prompting relocation of China’s manufacturing jug-gernaut, a growth engine of the Chinese economy.     

Back on Solid Ground

<正>The Chinese economy steers a steady course of more balanced growth, but inflation and asset bubbles are posing daunting challenges     

MARKET WATCH

By ordering another hike in the reserve requirement ratio,China attempts to soak up excess liquidity.Chinese commercial banks issued higher-than-expected new loans in March,highlighting simmering inflation risks.House prices continue edging higher in most major cities,despite tough policies.State-owned enterprises are bursting with vitality,reaping juicy profits in the first quarter.China is bound to benefit from emerging global electric vehicle demand,though challenges remain.China’s telecom equipment maker Huawei cashes in on profitable overseas markets.     

Even Rarer

<正>China reduces its export quota of rare earths for the first half of 2011 Rare earth metals will soon become an even hotter commodity than