The determination of lysergide (LSD) in urine by high-performance liquid chromatography-isotope dilution mass spectrometry (IDMS)

The use of isotope dilution mass spectrometry (IDMS) has been investigated for the forensic confirmation of lysergic acid diethylamide (LSD) in urine by LC-MS. The advantages of using a deuterated analog of LSD as an internal standard over methysergide are discussed. This study includes a comparison of the electrospray mass spectra of LSD, LSD-d3 and methysergide, and discusses the choice of suitable ions for use in selected ion monitoring (SIM) mode. An IDMS method is presented for the LC-MS confirmation of LSD in urine, with a limit of quantification (LOQ) of 0.5 ng/mL, reflecting the forensic requirement at this laboratory. Under some circumstances the LOQ can be improved to 0.1 ng/mL. This method is linear in the range tested (up to 10 ng/mL LSD in urine) and has been validated in terms of accuracy and precision.     

Whose Europe is it anyway? The 1998 Stein Rokkan lecture

Abstract. This article addresses the issue of whether a model of deep European integration might be envisaged in a continent–wide process that might accompany eastern enlargement of the European Union. The paper argues that deep integration in Western Europe has been built on three dimensions: the functional; the territorial; and affiliational. The articulation of these three dimensions has evolved through not only the EU, but also a dense pattern of other transnational linkages, including those between immediate neighbours. Moreover, different west European countries have been linked into this process through varied patterns for 'domesticating' Europe. Efforts to develop an EU polity require the interplay of all three dimensions of integration, a tough goal for post–cold–war Europe in the western part of the continent, let alone in 'pan–Europe'.     

The Solitary Center: the Core Executive in Central and Eastern Europe

This article discusses the coordinative capacity of Centers of Government (COGs) in several Central and Eastern Europe countries. In formal terms, COGs are at the heart of the executive process; but their contribution to coherence in executive policymaking has remained limited. This observation applies both to coordination within the executive, and between the executive and other key participants in the political process. In important respects, the "solitary centers" operate in isolation from their political and institutional environment. In part, this weakness of linkage reflects the particular features of the post-Communist political systems; in part, it can be explained by a lack of nodality, authority and policy expertise at the COG. There are good reasons to assume that, as policy systems mature, problems of linkage will decline in significance. But this outcome cannot be taken for granted. Instead, we might be witnessing the emergence of a "new administrative type" in some Central and Eastern European countries.