The influence of physical properties and lipid content of bile on the human blood/bile ethanol ratio

The relationship between ethanol levels in blood and bile was determined in human postmortem specimens. The influences of several physical properties--surface tension, specific gravity and viscosity--and bile lipid content on the blood/bile ethanol ratio were evaluated. A gas chromatographic direct injection technique was employed to determine the ethanol concentrations in postmortem blood and bile specimens. A positive correlation was established between the levels in the two fluids. No correlation could be found between the blood/bile ethanol ratios and the aforementioned physical properties of bile. Correction of the observed bile ethanol for lipid content had an insignificant effect on the ratio. The average blood/bile ethanol ratio was 1.03 +/- 0.29 (range: 0.32-2.91). The wide range observed makes it undesirable to use bile ethanol concentrations to predict specific blood ethanol concentrations. However, under certain conditions, bile ethanol levels may be used to estimate blood concentrations within a range of values.     

The Enactment of the Matrimonial Causes Act 1857: The Campbell Commission and the Parliamentary Debates

Rather surprisingly none of the existing accounts of the Matrimonial Causes Act 1857 considers the mechanics of reform which brought about the legislation in any great detail. Yet this subject as much as the final legislation merits attention in its own right. The nineteenth century in England was a significant period of law reform and the legislation provides a vivid illustration of the inner workings of the process. The passage of the Matrimonial Causes Act 1857 was not entirely smooth. The fact that it succeeded at all makes it an ideal case study in Victorian law reform. This article considers the pressures for divorce reform, the working of a Royal Commission, the debates in Parliament, and ultimately how reform was finally achieved through a series of compromises between those who wanted more radical change and defenders of the status quo.     

Quantitative PCR overestimation of DNA in samples contaminated with tin

Metals can pose challenges while conducting forensic DNA analysis. The presence of metal ions in evidence-related DNA extracts can degrade DNA or inhibit PCR as applied to DNA quantification (real-time PCR or qPCR) and/or STR amplification, leading to low success in STR profiling. Different metal ions were spiked into 0.2 and 0.5 ng of human genomic DNA in an “inhibition study” and the impact was evaluated by qPCR using the Quantifiler™ Trio DNA Quantification Kit (Thermo Fisher Scientific) and an in-house SYBR Green assay. This study reports on a contradictory finding specific to tin (Sn) ions, which caused at least a 38,000-fold overestimation of DNA concentration when utilizing Quantifiler Trio. This was explained by the raw and multicomponent spectral plots, which indicated that Sn suppresses the Quantifiler Trio passive reference dye (Mustang Purple™, MP) at ion concentrations above 0.1 mM. This effect was not observed when DNA was quantified using SYBR Green with ROX™ as the passive reference, nor when DNA was extracted and purified prior to Quantifiler Trio. The results show that metal contaminants can interfere with qPCR-based DNA quantification in unexpected ways and may be assay dependent. The results also highlight the importance of qPCR as a quality check to determine steps for sample cleanup prior to STR amplification that may be similarly impacted by metal ions. Forensic workflows should recognize the risk of inaccurate DNA quantification of samples that are collected from substrates containing tin.     

Mentoring programs to affect delinquency and associated outcomes of youth at risk: A comprehensive meta-analytic review

Objectives

To conduct a meta-analytic review of selective and indicated mentoring interventions for effects for youth at risk on delinquency and key associated outcomes (aggression, drug use, academic functioning). We also undertook the first systematic evaluation of intervention implementation features and organization and tested for effects of theorized key processes of mentor program effects.

Methods

Campbell Collaboration review inclusion criteria and procedures were used to search and evaluate the literature. Criteria included a sample defined as at risk for delinquency due to individual behavior such as aggression or conduct problems or environmental characteristics such as residence in a high-crime community. Studies were required to be random assignment or strong quasi-experimental design. Of 163 identified studies published from 1970–2011, 46 met criteria for inclusion.

Results

Mean effects sizes were significant and positive for each outcome category (ranging from d?=?0.11 for academic achievement to d?=?0.29 for aggression). Heterogeneity in effect sizes was noted for all four outcomes. Stronger effects resulted when mentor motivation was professional development but not by other implementation features. Significant improvements in effects were found when advocacy and emotional support mentoring processes were emphasized.

Conclusions

This popular approach has significant impact on delinquency and associated outcomes for youth at risk for delinquency. While evidencing some features may relate to effects, the body of literature is remarkably lacking in details about specific program features and procedures. This persistent state of limited reporting seriously impedes understanding about how mentoring is beneficial and ability to maximize its utility.     

The Role of Culture in Knowledge Sharing in a Public-Sector Organization in Ghana: Revisiting Hofstede’s Model

The purpose of this study was to ascertain the role of culture in knowledge-sharing drawing on Hofstede’s culture framework. The case study research design was employed as the research design. Semistructured interview guide was used as the data gathering instrument. Data analysis was done using the thematic analysis technique. Under power distance, four themes were identified as being crucial in knowledge sharing in Afiya Kwabre District Assembly. These factors are decision-making involvement, power and status, delegation of responsibilities, and respect and fairness. In addition, three major themes emerged under uncertainty avoidance—broadening knowledge, job security, and group membership.     

Depictions of correctional officers in newspaper media: an ethnographic content analysis

The public relies on the media for most of its information about the criminal justice system. Unfortunately, media depictions of justice actors are not always accurate which, in turn, can lead to distorted images about the system and its operations. Using ethnographic content analysis to analyze 489 articles from major newspapers across the United States, this study seeks to discern how correctional officers and the jobs that they perform are portrayed in print media. The results suggest that correctional officers are overwhelmingly portrayed negatively, with 79.6% of the articles in the research sample presenting one of six distinct negative themes. A typology of these themes is explored in detail, along with its implications for societal support for corrections and correctional officers, especially with regard to the media’s potential contributions to officers’ job stress, burnout, and job dissatisfaction.     

Access to credit for non‐formal micro‐enterprises in Botswana

The literature on micro‐enterprises identifies a lack of capital as a primary constraint to enterprise development. Potentially, Botswana could be different as the commercial banking system has excess liquidity and the government has established relevant lending institutions and several financial assistance programmes. On the basis of a 1992 survey of 1,140 micro‐enterprises engaged in non‐formal activities in seven urban centres and villages in Botswana this study finds the situation in Botswana to be similar to the conclusions reported in the literature for other countries. There is a need for institutional changes which channel loanable funds to micro‐enterprises in a manner that addresses their respective capital constraints and encourages the entrepreneurs to become responsible savers and borrowers. The article draws on the literature and on the experience of several successful micro‐enterprise loan schemes to outline the essential features of needed programme delivery changes.