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101.
Determination of blood/serum ratios of different forensically relevant analytes in authentic samples
Jantos R Schuhmacher M Veldstra JL Bosker WM Klöpping-Ketelaars I Touliou K Sardi GM Brookhuis KA Ramaekers JG Mattern R Skopp G 《Archiv für Kriminologie》2011,227(5-6):188-203
For forensic toxicological investigations only whole blood, but no serum is often available. Pharmacokinetic data are helpful for interpreting the results, but most of these studies indicate serum or plasma concentrations. In order to obtain reliable conversion factors which also take intersubject variability into account, the blood/serum ratios (B/S) of oxycodone, morphine, fentanyl, hydromorphone, zopiclone, MDMA, dexamphetamine, alprazolam, risperidone and 9-hydroxyrisperidone were determined by LC-MS/MS using authentic samples. Blood and corresponding serum samples were obtained from driving studies performed with controlled or known dosages of the above drugs. The analytes were analysed in blood and serum and the following mean B/S ratios (relative standard deviations) were determined: oxycodone 1.48 (8.19 %); morphine 1.03 (3.59 %); fentanyl 0.87 (13.9 %); hydromorphone 1.04 (8.11 %); zopiclone 0.89 (16.1 %); MDMA 1.19 (8.04 %); dexamphetamine 0.89 (10.9 %); alprazolam 0.81 (5.84 %); risperidone 0.65 (7.52 %); 9-hydroxyrisperidone 0.73 (12.3 %). These mean values are largely in line with those reported in the literature. The B/S ratios did not appear to depend on partition coefficients, whereas there was strong evidence that B/S ratios decreased with increasing plasma protein binding. 相似文献
102.
Brandon L. Bartels Janet M. Box-Steffensmeier Corwin D. Smidt Rene M. Smith 《Electoral Studies》2011,30(1):210-222
Central to traditionalist and revisionist perspectives of individual-level party identification is a debate about the stability of party identification. We revisit the debate about the dynamic properties and processes underlying party identification. We present a conceptual framework that defines heterogeneity and state dependence as endpoints of a continuum underlying partisan stability, which is important in understanding an individual’s capacity for updating partisanship. Using panel data from the 1992-1996 National Election Study, we estimate dynamic, random effects multinomial logit models of party identification that distinguish between heterogeneity and “true state dependence.” In accord with traditionalist perspectives, our evidence suggests that in general, minimal state dependence underlies party identification; party identification is strongly stationary. However, we find that age enhances the magnitude of state dependence, which provides some support for revisionist theories. Overall, our work showcases how explaining individual-level dynamics expands our knowledge of partisan stability. 相似文献
103.
Janet Lee 《澳大利亚女权主义者研究》2011,26(70):469-483
Abstract Stella Miles Franklin (1879–1954) is best known for contributions to a uniquely Australian literary tradition. However, during her American years (1906–1915) when she worked in Chicago with the National Women's Trade Union League, Franklin wrote much unpublished fiction in the New Woman literary genre common to early-twentieth-century US women's traditions. This paper focuses on two such little-known unpublished stories: ‘Uncle Robert's Wedding Present’ (1908) and ‘Teaching Him’ (1909), discussing ways their entanglements with questions of marriage and economics are grounded in Franklin's work and personal life and in the intellectual influences that shaped her writing. 相似文献
104.
Contextual factors that contribute to race differences in reporting crime to the police are an important element in Donald Black??s theory of the behavior of the law, yet few studies have investigated whether these differences vary depending on social context. The present study investigates whether the relationships between victim and offender race and the reporting of crime are moderated by the level of racial stratification in a given place as Black??s stratification hypothesis would predict. Using victim survey data from 40 metropolitan areas, as well as data from other sources, we find results that are consistent with Black??s stratification hypothesis, namely, that victim and offender race are more strongly associated with the reporting of crime in those metropolitan areas where the gap in economic status between blacks and whites is larger and the groups are more residentially segregated. The theory, however, is unable to account for the high rates of reporting of black-on-black assaults found across the 40 metropolitan areas. The question of how the needs of black victims may outweigh their reluctance to call the police is an important issue for future research. 相似文献
105.
Women who enter college with a sexual victimization (SV) history may be at particular risk for deleterious outcomes including maladaptive alcohol involve posttraumatic stress, and re-victimization. Further, pre-college SV may be an impediment for the achievement of academic mile and may negatively impact the transition into college. Recent work shows that the method of coercion used in SV may be an important predictor of post-victimization outcomes. As such, the identification of pathways between type of SV and outcomes can aid in early identification and intervention for those at highest risk. In a sample of newly-matriculated female college students, this study examined unique outcomes associated with two specific types of SV, (1) threats/use of physical force (Force SV) or (2) incapacitation (Incap SV). Participants completed assessments of SV, alcohol involvement, posttraumatic stress, and academic outcomes at 6 time-points over their first year of college. Results showed differential outcomes based on pre-matriculation exposure to Force SV or Incap SV. Women with Incap SV were higher on problem drinking indices whereas women with Force SV were at greater risk for re-victimization and marginally more PTSD symptoms. Having a history of either type of SV predicted attrition, but there were no differences when comparing Force SV to Incap SV. Overall, results from this study support the utility of delineating SV experiences by method of coercion, and point to the potential of highlighting different outcomes in tailored intervention programs. 相似文献
106.
Objectives
This study was designed to test two problem-focused situational crime prevention treatments (protective display fixtures and special high-loss product handling procedures) on loss and sales levels of a perennial ‘hot product’ (premium shaving blade replacement packs). 相似文献107.
108.
Janet Rowe 《Local Government Studies》2013,39(2):71-92
Local authorities in the UK have come under renewed pressure from central government both to adopt Local Agenda 21 and to advance participative democracy. In late 1996/early 1997, the (then) new unitary authority of Bath and North‐East Somerset Council set up a Local Agenda 21 Issue Commission to review its ‘sustainability’ performance and policy development practice with the direct involvement of the community. The way in which the commission was conceived and conducted resulted in difficulties in identifying and carrying out its task. Nonetheless, it kick‐started significant steps towards LA 21 within the council, and provided valuable insights into LA 21 implementation, and the nature of meaningful consultation. 相似文献
109.
Janet Badia 《Women's Studies: An inter-disciplinary journal》2013,42(1):137-139
110.