Suicide by multiple blunt head traumatisation using a stone

Apart from collisions with road or rail vehicles and falls from height, self inflicted blunt force is a rare suicide method and mainly seen in psychiatric patients. The paper presents a rare case of suicide by active blunt force. A 68-year-old man committed suicide by repeatedly hitting his head with a stone. He sustained a craniocerebral trauma and finally died from hypothermia due to the low outdoor temperature. According to the relatives, the man was not diagnosed with a mental disorder or suicidal tendencies. Uncommon manners of self-harm are challenging for those involved in the investigation, and a differentiation between suicide, accident and homicide can only be made in synopsis of all findings.     

Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood

Venlafaxine (VEN) is an antidepressant drug mainly metabolized by the cytochrome P450 (CYP) enzyme CYP2D6 to the active metabolite O-desmethylvenlafaxine (ODV). VEN is also metabolized to N-desmetylvenlafaxine (NDV) via CYP3A4. ODV and NDV are further metabolized to N,O-didesmethylvenlafaxine (DDV). VEN is a racemic mixture of the S- and R-enantiomers and these have in vitro displayed different degrees of serotonin and noradrenaline reuptake inhibition. The aim of the study was to investigate if an enantioselective analysis of VEN and its metabolites, in combination with genotyping for CYP2D6, could assist in the interpretation of forensic toxicological results in cases with different causes of deaths. Concentrations of the enantiomers of VEN and metabolites were determined in femoral blood obtained from 56 autopsy cases with different causes of death. The drug analysis was done by liquid chromatography tandem mass spectrometry (LC/MS/MS) and the CYP2D6 genotyping by PCR and pyrosequencing. The mean (median) enantiomeric S/R ratios of VEN, ODV, NDV and DDV were 0.99 (0.91), 2.17 (0.93), 0.92 (0.86) and 1.08 (1.03), respectively. However, a substantial variation in the relationship between the S- and R-enantiomers of VEN and metabolites was evident (S/R ratios ranging from 0.23 to 17.6). In six cases, a low S/R VEN ratio (mean 0.5) was associated with a high S/R ODV ratio (mean 11.9). Genotyping showed that these individuals carried two inactive CYP2D6 genes indicating a poor metabolizer phenotype. From these data we conclude that enantioselective analysis of VEN and ODV can predict if a person is a poor metabolizer genotype/phenotype for CYP2D6. Knowledge of the relationship between the S- and R-enantiomers of this antidepressant drug and its active metabolite is also important since the enantiomers display different pharmacodynamic profiles.     

Der Abschluss von Swap-Geschäften durch Gemeinden und die Grenzen der Gemeindeautonomie

Gemeinden haben mit Swap-Geschäften zur Absicherung des Zinsrisikos teilweise erhebliche Verluste erlitten. Dieser Umstand führt mittlerweile auch zu Gerichtsverfahren, in welchen die Gültigkeit dieser Geschäfte streitgegenständlich ist. Im folgenden Beitrag werden die Voraussetzungen für die Gültigkeit von Swap-Geschäften der Gemeinden untersucht.     

Agilität als Chance für einen neuen Anlauf zum demokratischen Unternehmen?

There has been a long-standing discussion since the 1980s about the question whether new production models harbor a potential for extended employee participation and involvement, in most cases with disillusioning results. This paper is concerned with so called “agile methods”, which play an important part in the area of knowledge work in the course of the digital transformation. On the basis of two case studies from software development and industrial R&D, the paper examines the concrete implementation of these methods and the employees’ perspective upon them and their consequences. The result is that agile methods present a potential for extended employee participation and involvement; however, the realization of this potential depends on the concrete way how the agile concept of “empowerment” is implemented.     

Ahmadis or Indonesians? The polarization of post-reform public debates on Islam and orthodoxy

Since the fall of Suharto in 1998, Indonesian public discourse about “mainstream” Muslim identity and practice has polarized sharply into various factions. This article offers a detailed analysis of a subset of this discourse that focuses on the Ahmadiyya in order to grasp how the new normative contours of Islam are being shaped in Indonesia. I make three arguments: First, the discourse is homogenizing what was once a wide spectrum of identitarian positions, and that consequently, Islamic diversity in Indonesia is shrinking. Second, the various internally homogenized sets of arguments for and against the Ahmadiyya mis-engage with each other in a way that produces social fragmentation and further polarization. Third, these arguments produce exclusionary mechanisms that reinforce each other. Both the opponents of the Ahmadiyya and their defenders exclude Ahmadis from conceptions of an Indonesian “majority.” This dynamic in Indonesian public discourse has resulted in the acceleration of the marginalization of the Ahmadiyya within an increasingly fragmented Indonesian society.     

Leadership Experiences Within Civil Organizations and Candidacy in Public Elections: Causal Evidence from a Quasi-Experimental Approach

Standing as a candidate in public elections has been characterized as the ultimate act of political participation. We test the hypothesis that acquiring office within civil organizations increases the probability of becoming a candidate in public elections. In order to take self-selection problems into account, we provide quasi-experimental evidence using election discontinuities, in which we compare the likelihood of being nominated for public office between closely ranked winners and losers in Swedish student union (SU) elections. Our original data cover 5,000 SU candidates and register data on their candidacies in public elections (1991–2010). The analysis provides support to the hypothesis: Students elected to SU councils were about 34 percent (6 percentage points) more likely to become a candidate in a public election than SU council candidates who were not elected. The causal impact is fairly stable over time. The analysis makes important contributions to two interrelated bodies of literature: First, it provides political recruitment literature with causal evidence that acquiring leadership experiences at arenas outside of representative democratic institutions facilitate entry into election processes. Second, it provides strong evidence to an increasingly contested issue within political participation research by showing that certain organizational activities increase individuals’ political involvement.     

„Outstanding universal value“. Die Arbeit an der Universalisierung des Wertvollen im UNESCO-Welterbe

The UNESCO World Heritage List is an international inventory of natural and cultural sites that are, according to the conception of its initiators and administrators, of importance for mankind as a whole. The evaluation of the list can be interpreted as a specific form of the social production of the valuable. Focusing on the cultural sites, the paper argues that the production of World Heritage renders a form of practical universalization of the value of particular goods. It centres on the questions of how a site is produced as culturally valuable, how its value is universalized, and what role is played by the concept of authenticity in the process. Two aspects of the evaluation practice are examined with regards to the production of universalization: working with and working on the assessment criteria. It is shown that universality and particularity are interwoven in this practice.     

Hierarchical,Decentralized, or Something Else? Opposition Networks in the German Bundestag

Members of the German parliament may force government to publicly answer questions by issuing minor interpellations (kleine Anfragen). We use 3,608 interpellations from the session 2009–13 that have been signed by authoring and supporting members to construct the social network of support relations among members within the three opposition parties. We find that parties differ markedly in terms of internal structure. While social democrats organize hierarchically, Greens cooperate horizontally. The network for socialist Linke in contrast shows signs of homophily and social segregation. Our approach yields a novel perspective on intraparty politics in parliamentary systems which are notoriously difficult to analyze.