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311.
Ailiang Chen M.Sc. Guoqing Wang M.Sc. Qin Cao B.Sc. Yan Wang M.Sc. Zhaohui Zhang Ph.D. Yimin Sun M.Sc. Hui Wang M.Sc. Chaoyi Xu B.Sc. Qi Zhou B.Sc. Pei Han B.Sc. Miao Liu B.Sc. Yang Yang B.Sc. Wanli Xing Ph.D. Keith R. Mitchelson Ph.D. Jing Cheng Ph.D. 《Journal of forensic sciences》2009,54(4):953-960
Abstract: The abuse of antibiotic drugs during animal production remains a worldwide problem and the subsequent detection of the residues of various drugs present at low concentrations in complex biological matrices poses significant analytical challenges. The present study outlines a practical biochip assay system to identify antibiotic residues in different animal tissue extracts. The system uses a simple but efficient multiresidue sample extraction procedure to isolate the antibiotic residues which were then identified directly using high‐affinity monoclonal antibodies presented in a competitive immunoassay with conjugated antibiotic hapten‐chips. The hapten‐chip can analyze six samples each for eight antibiotics on a single chip within 3 h. The analytical results with both artificial positive standard samples and the incurred samples show that the antibody hapten‐chip system has a comparable accuracy and a similar sensitivity to a standard ultra performance liquid chromatography–mass spectrometry (MS)/MS assay. In conclusion, an effective analytical screening system based on antibody hapten‐chip was developed for detecting multiple antibiotic residues from multiple samples. 相似文献
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ABSTRACT This paper examines the control of networks, an issue that we believe is critical for explaining the overall effectiveness of public networks. We first discuss why it is important to study the issue and why it has been neglected as a topic by public management and organization scholars. We then present the various types of control and how they are utilized in a network context. Finally, we discuss how the mechanisms of control might be related to network effectiveness, drawing heavily on an understanding of how this relationship is addressed by contingency theorists. We close by posing challenges to researchers for developing new insights into the control of networks and why this knowledge is relevant for public managers and policy makers. 相似文献
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Keith J. Bybee 《Law & social inquiry》2013,38(1):215-221
The author explains the origins of All Judges Are Political—Except When They Are Not: Acceptable Hypocrisies and the Rule of Law (2010) as a response to a fundamental question posed by legal realism: How can the judicial process be permeated with politics and yet remain an accepted part of a legitimate legal system? The author demonstrates the ongoing importance of this question by examining debates over the place of constitutional law in the law school curriculum and by assessing public perceptions of the Supreme Court's ruling on health care reform. The author then addresses the critical appraisals presented by the symposium contributors. The critiques are taken as road maps for extending the author's arguments in new directions. 相似文献
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