Detection and validated quantification of 21 benzodiazepines and 3 "z-drugs" in human hair by LC-MS/MS

A method for detection and quantification of 21 benzodiazepines and the pharmacologically related "z-drugs" in human hair samples was developed and fully validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). After methanolic and methanolic/aqueous extraction, the analytes were separated using two different LC-MS systems (AB Sciex 3200 QTRAP and AB Sciex 5500 QTRAP). Separation columns, mobile phases and MS modes for both systems were: Phenomenex Kinetex, 2.6 μm, 50/2.1; 5mM ammonium formate buffer pH 3.5/methanol, total flow 0.75 mL/min; electrospray ionization (ESI), multiple reaction monitoring (MRM), information dependent acquisition (IDA), enhanced product ion scan (EPI). The assays were found to be selective for the tested compounds (alprazolam, 7-aminoclonazepam, 7-aminoflunitrazepam, bromazepam, chlordiazepoxide, clonazepam, N-desalkylflurazepam, diazepam, flunitrazepam, flurazepam, alpha-hydroxymidazolam, lorazepam, lormetazepam, midazolam, nitrazepam, nordazepam, oxazepam, phenazepam, prazepam, temazepam, triazolam, zaleplon, zolpidem and zopiclone), all validation criteria were in the required ranges according to international guidelines, except for bromazepam. Matrix effects, and process efficiencies were in the acceptable ranges evaluated using the post-extraction addition approach. Lower limits of quantification were between 0.6 and 16 pg/mg of hair. The LC-MS/MS assay has proven to be applicable for determination of the studied analytes in human hair in numerous authentic cases (n=175).     

More Sanctions – Less Prison? A Research Note on the Severity of Sanctions Proposed by Survey Participants and how it is Affected by the Option to Combine a Prison Term with Other Sanctions

Public opinion has come to be given an increasingly important role in the crime policy debate of western countries. The task of problematising different pictures that emerges from different studies of public opinion on appropriate sentences thus becomes an important task. In this article the question is whether survey respondents, in their choice of reactions to crime, tend to propose shorter prison sentences when they combine the prison term with other measures? If so, different response instructions can lead to different conclusions as to what survey participants consider to be appropriate sentences. Earlier research points at such tendencies to some extent. In order to examine this question, two comparisons will be made. In the first, survey respondents who chose to combine a prison sentence with other measures is compared with those who chose to propose a prison sentence as the only sanction. In the second, participant who were instructed to only propose a single sanction will be compared with those who were given the opportunity to combine two sanctions. Both comparisons are made with regard to the lengths of the proposed prison sentences. No systematic differences emerge. The correlation between the length of prison term proposed and the choice, or opportunity given, to combine the prison term with other measures varies, for example, across the different offences examined. The choice of appropriate reactions to crime is based on a more advanced deliberation than whether different sanctions may be combined.     

Welfare Nationalism and Popular Support for Raising the Child Allowance: Evidence from a Norwegian Survey Experiment

Refugee and labour immigration have placed the issue of immigrants’ access to welfare benefits high on the political agenda. This article explores how voter preferences for increases in the child benefit change when respondents are reminded about immigrants’ access to benefits. The survey experiment shows that information about newly arrived immigrants’ access to child benefit has only a small impact on support for increasing the child allowance. By contrast, information about labour migrants’ access to benefits for children living in another European Union country has a strong impact, and the observed sensitivity to this cue is not to the same extent confined to respondents who otherwise support welfare dualism.     

Turning defiance into compliance with procedural justice: Understanding reactions to regulatory encounters through motivational posturing

This paper uses Braithwaite's motivational posturing framework to explain how individuals react to encounters with regulatory authorities. Of interest is whether procedural justice can reduce defiance and improve self‐reported compliance among individuals who are either resistant or dismissive of regulatory authority. Using longitudinal survey data collected from tax offenders (Study 1), and individuals who had a recent police‐citizen interaction (Study 2), it will be shown that procedural justice can promote compliance behavior. Procedural justice is also found to be effective for reducing resistant forms of defiance over time, but not dismissive defiance. Further, the results reveal that neither resistant defiance nor dismissive defiance moderate the effect of procedural justice on compliance, suggesting procedural justice works equally well for both low and high resisters and low and high disengagers. Finally, an unexpected result reveals that resistance, but not dismissive defiance, mediates the effect of procedural justice on self‐reported compliance behavior. The findings have implications for procedural justice research and for the regulation of defiance.     

Reflections on the Iraq War: Implications for U.S. Foreign Policy

Our foreign policy elites, the press, our elected representatives and the general public internalize “lessons” from each war, although the lessons may be wrong or misapplied. How we arrive at such consensus lessons is a mystery. It is too early to predict what lessons from Iraq will guide future U.S. decision-making. But on the situation as it now stands, it is possible to make some broad generalizations concerning what went right in Iraq and what went wrong.     

A biomechanical study of the human vertebral artery with implications for fatal arterial injury

We studied the biomechanical behaviour of ring and strip specimens from along the length of 18 vertebral arteries taken from 16 subjects aged 28-90 years, in order to consider some of the factors which may play a role in vertebral artery rupture. The method was chosen to allow a comparison between circumferential distension (ring samples) and longitudinal extension, (strip samples). The samples were extended between the jaws of a tensile testing apparatus until the specimen broke and a number of biomechanical parameters were derived. These were the percentage extension to break, the tensile strength, Young's modulus and the peak load. There were a number of important findings. The vertebral artery was shown to be susceptible to longitudinal stretching with a number of strip samples breaking when extended by as little as 16-20%. The tensile strength and load at peak of the strip specimens were correspondingly lower than for the ring samples. Marked intersubject variations were shown for all these parameters and prominent changes in behaviour occurred along the vertebral artery. This study indicates that the artery may be susceptible to head and neck movements which cause the vessel to stretch, and intersubject variations in behaviour may be one important explanation for the marked differences in outcome which appear to exist in subjects who suffer broadly similar head and neck insults.     

胸外按摩致肋骨骨折法医病理学分析

目的　探讨胸外按摩致肋骨骨折特点。　方法　对 1990～ 2 0 0 0年间华西医科大学法医学院所做 30例胸外按摩致肋骨骨折的尸检进行法医病理统计分析。　结果　肋骨骨折男性 2 8,女性 2例 ,年龄为 18～ 6 8岁 ,胸外按摩骨折主要发生在疾病、电击伤、溺死及中毒病例 ,以第 6～ 9肋骨的腋前、中线骨折常见 ,多为左侧。　结论　胸外按摩与外伤所致肋骨骨折具有明显的区别。     

Promoting Muslims’ Willingness to Report Terror Threats to Police: Testing Competing Theories of Procedural Justice

The heightened threat of terrorism in the West has resulted in more power being granted to police. However, new anti-terror laws and heavy-handed policing practices can stigmatize Muslim communities. Using survey data from 800 Australian Muslims this paper examines whether procedural justice policing in counter-terrorism enhances Muslims’ feelings of social inclusion, and promotes their intentions to report terror threats to police. Of interest is how procedural justice influences Muslims who feel less socially included. Three competing theoretical frameworks differ in the predictions they make about when and why procedural justice influences excluded groups. This paper considers each framework and discusses how each explains the relationships between our variables of interest. Our findings show that procedural justice is positively associated with social inclusion and intentions to report terror threats to police. Findings also show that social inclusion both moderates and partially mediates the effect of procedural justice on reporting intentions.