大鼠肝细胞DNA含量与早期死亡时间关系的图像分析研究

实验选择 15只大鼠 ,处死后 ,在 2 4h内 ,每隔 1h取肝组织块进行细胞学涂片、福尔马林液固定、Feul gen染色、自动图像分析仪测量、统计学处理数据。结果表明 ,肝细胞DNA含量在死后 2 4h内 ,随死亡时间的延长而较有规律的下降。其中积分光密度、平均光密度、异形指数是用来研究死亡 2 4h内肝细胞DNA降解规律 ,并准确推断死亡时间的较好指标。     

应用40Hz听觉相关电位与听性脑干反应评估听阈

对 42例 74耳（正常听力组 32耳,检案中主诉听力下降 42耳）分别进行纯音测定,声导抗测定,听性脑干反应 (Auditory Brainstem Response,ABR)及 0.5～ 2kHz范围的 40Hz听觉相关电位 (40Hertz Auditory Event－ related Potential,40Hz AERP)测定,对其中 20耳进行睡眠及清醒两种状态的 40Hz AERP测定。将纯音听阈、 40Hz AERP反应阈、 ABR反应阈三者之间进行比较分析。结果表明,正常听力耳 40Hz AERP反应阈值较纯音测听阈值高,在不同频率的校正值 (差值 )不同, 0.5 kHz为 12.7± 6.4(dBnHL); 1kHz为 14.7± 6.3(dBnHL); 2 kHz为 15± 5.6(dBnHL)。 ABR阈值比行为听阈高,校正值为 8.9± 5.3(dBnHL)。睡眠状态时 40Hz AERP阈值较清醒状态阈值高,校正值为 9.7± 2.45(dBnHL)。检案中主诉听力下降者主、客观语音频率均值之间明显不相符 ,误差率为 61％。本研究表明单纯使用 ABR、纯音测听中任何一种方法估计语音频率听阈均有一定的误差。     

大鼠脑挫伤后组织学及Bax/Bcl-2表达的研究

采用自制大鼠右顶叶局灶性脑挫伤模型,进行组织学和 Bax/Bcl－ 2的免疫组织化学法研究。结果发现 :伤后 12h～ 24h,挫伤灶周围神经细胞和星形胶质细胞形态学发生改变,白细胞附壁和游出;伤后 4d,挫伤灶周围出现大量的泡沫细胞和核大而深染的星形胶质细胞; 8～ 10d,挫伤灶处形成软化灶; 12～ 14d,挫伤灶愈合变成胶质细胞结节,或者变成囊状,可见大量的星型胶质细胞及新生毛细血管,可见含铁血黄素颗粒沉积。 Bax/Bcl－ 2表达水平与伤后经历时间有一定相关性。     

Human rights and the AIDS crisis: the debate over resources

In his plenary presentation of 11 July 2000 at the XIII International AIDS Conference, Kenneth Roth, the Executive Director of Human Rights Watch, the largest US-based human rights organization, reflects on whether a human-rights perspective can help us confront the AIDS crisis. More specifically, he asks the question whether human rights can help us meet the urgent challenge of securing the vast resources we need for treatment and prevention. Mr Roth believes they can. He argues that human rights are a powerful tool for meeting basic human needs, but that their contribution to the fight against AIDS is not as simple or straightforward as many often assume. In his presentation, he explains why.     

Managed care liability today: laws, cases, theories, and current issues

Managed care entities face numerous liability issues in today's changing healthcare environment. This Article provides the plaintiff with a comprehensive road map for navigating the many avenues of managed care liability. The author describes ERISA pre-emption provisions and suggests ways plaintiffs' attorneys can strive to narrow the pre-emption. The Article also provides in-depth analysis of each theory of managed care liability that has been litigated against managed care entities to date, and then goes on to explore state laws imposing liability on managed care entities, and how HMO liability is being reformed through legislative action. For plaintiffs' attorneys seeking the full spectrum of theories of managed care liability, or for defendants' attorneys wanting to remain updated on all potential claims to defend, this Article constitutes an extensive primer on the current issues.     

Like father like son: Imprisonment of fathers and the psychological adjustment of sons

The present study demonstrates that profiles of children from families with imprisoned fathers were more similar to those of juvenile delinquents and less similar to the norm group than were the profiles of children from divorced families. Based on findings presented, it would not be justified to conclude that father absence and father imprisonmentper se were the causes of negative psychological reactions. Discordant family relationships before the father left the family could have primarily caused the disturbance of these children.Received Ph.D. in psychology from the University of Innsbruck, Austria. Main research interest is developmental psychology.     

Studying schizophrenia outside the psychiatric setting

Two groups of college students were identified using the MMPI as a screening device: those with normal profiles and those with schizophrenic profiles. All those with previous psychiatric treatment were eliminated. A third group of hospitalized schizophrenics was matched to the first two along lines of age, sex and socioeconomic status. The three groups were then studied via a semistructured interview and compared for the clinical features of hospitalized schizophrenics and for objective enironmental stresses. As predicted, a group of well-functioning, untreated schizophrenics was delineated. The usefulness of the MMPI as a screening device is clarified, and the question of the true prevalence of schizophrenia is discussed. Contrary to prediction, the well-functioning schizophrenics were similar to the hospitalized schizophrenics, not to the normal controls, with regard to objective environmental stresses. The possible meaning of this is discussed considering the concept of subjective environmental stresses.This research is in part supported by USPHS grants MH-18991, MH-19477-01, and State of Illinois 131-13-RD, State of Illinois 218-12-RD.This reasearch is part of an extensive program investigating schizophrenia which is being conducted jointly by the Psychosomatic and Psychatric Institute of Michael Reese Hospital, the Department of Psychiatry, Pritzker School of Medicine, the University of Chicago, and the Illinois State Psychiatric Institute.Received M.D. from Northwestern University. Served psychiatric residency at the Psychosomatic and Psychiatric Institute of Michael Reese Hospital. Main interest is in psychotherapy and psychodynamics of youth.     

Ego identity status and decision styles

It was hypothesized that the decision processes used in coping with the identity crisis would be related to more general decision styles in that identity achievers and moratoriums would tend to be reflective in their conceptual tempo while foreclosures would typically be impulsive. No prediction was made about identity diffusions. Ninety-two male college students were given an identity status interview and the Matching Familiar Figures Test. The results were consistent with the hypotheses, and in addition it was found that identity diffusions were generally impulsive. Since conceptual tempo has been found to be well established in childhood, the results of this study have implications for the early prediction of adult identity status.Received Ph.D. from SUNY/Buffalo. Recent research has been mainly concerned with the development of ego identity and correlates of the different identity statuses.Received Ph.D. from SUNY/Buffalo. Recent research has been mainly concerned with the development of ego identity and correlates of the different identity statuses.