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Acetaminophen (paracetamol), a widely used analgetic drug, is well tolerated at therapeutic doses, but may cause severe hepatotoxicity when ingested in large overdose. Self-poisoning is still very popular in adults and accidental ingestion of one single overdose occurs occasionally in children. In contrast, lethal intoxication in children after repeated administration of therapeutic doses is a very rare event. This case report describes an iatrogenic acetaminophen overdosing in a 5-year-old child receiving 8.5 g acetaminophen in 48 h. Fulminant liver failure developed within 60 h. Autopsy findings included panlobular liver cell necrosis. Acetaminophen serum levels were rather low compared to cases with ingestion of one single overdose. Postmortem diagnosis of chronic acetaminophen intoxication as cause of death should include the clinical history as well as, if available, the calculated drug serum half-life.  相似文献   
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The article argues that the increase in crime and urban violence in Argentina, especially in Buenos Aires, can be explained as an outcome of the interaction of four factors: the new social relations established by neoliberalism; the incapacity of the state to resolve the social conflicts which have arisen from these new social relations; the failure to democratise the security forces; and the exclusion of a sector of society from the rights of effective democratic citizenship. The increase in crime and urban violence is, thus, analysed as a problem of governability.  相似文献   
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This paper develops a simple econometric strategy to operationalise the United Nations Children’s Fund’s (UNICEF’s) conceptual framework for nutrition. It estimates the extent to which child stunting correlates with investments in water, sanitation, and hygiene (WASH) across population groups (poor and nonpoor) and residence (urban and rural). Moving away from estimating single intervention marginal returns, the empirical framework of intervention packages is tested in Tunisia, a country with notable but uneven progress in reducing stunting. A successful nutritional strategy will thereby require mapping the distinctive intervention packages by residence and socio-economic status, away from universal policies, that more strongly correlate with reduction in stunting.  相似文献   
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This article presents an overview of the Ojibwa family over the past three centuries, from early European contacts to the present. It emphasizes the extent to which Ojibwa familial relations have long been embedded in extensive networks of kin that played major roles in the family lives of individuals of all ages. The article traces the effects of historical change on the Ojibwa family and examines continuity within Ojibwa kinship relations. The changes of the last century have taken a heavy toll on these relationships, yet, where they persist or are being revived, they are sources of strength and renewal.  相似文献   
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