Common mitochondrial DNA deletion associated with sudden natural death in adults

One of the most frequent causes of death in developed countries is sudden natural death (SND), which is the most common indication for medico-legal autopsies. Cardiac diseases are frequently detected among SND. Mitochondrial DNA (mtDNA) is easily damaged by reactive oxygen species, and it may cause dysfunction in tissues, leading to early events in cardiovascular disease. A specific mtDNA deletion of 4977 bp is associated to aging, myocardial dysfunction, and bioenergetic deficit. The potential link between mtDNA damage and SND has not been investigated before. Our aim was to evaluate the accumulation of the common mtDNA4977-deletion in cardiac muscle samples from autopsies of SND in adults (n = 14) in comparison to control samples from unnatural deaths (n = 12). Serial dilution-polymerase chain reaction method was performed to estimate the proportion of the total mtDNA harboring the mtDNA4977-deletion. Coefficient variation intra-assay was 8%, and inter-assay was 12%. MtDNA4977-deletion percentage was higher in samples obtained from victims of SND than in those from subjects who died of unnatural causes (p < 0.05). No differences in mtDNA4977-deletion were found between SND victims 39-51 years old, and no correlation was found between these samples and age, r = 0.30, p = 0.29 while it was significant among control samples, r = 0.68, p < 0.05. The association between mtDNA4977 deletion with SND victims might offer a tool to provide additional information to clarify complex SND investigations.     

Is domestic violence relevant?: An exploratory analysis of couples referred for mediation in family court

Mediation is an essential component of custody evaluation and reconciliation services in domestic courts. Data from 306 couples with and without a reported history of domestic violence (DV) who were ordered to attend an assessment for mediation were analyzed to determine differences in the mediation process. More than one third reported a history of DV. Chi-square analysis showed that differences in the mediation process exist between couples reporting DV and couples reporting no DV. A greater proportion of couples with reported DV (a) actually attended the court-mandated assessment session, (b) were deemed unsuitable to participate in the mediation process, (c) were in default of child-support payments, and (d) reported drug and alcohol abuse. No significant differences were found between the two groups in the measured mediation outcomes. Implications for the use of mediation with couples who reported DV and recommendations for future research are discussed.     

A program analysis of Esuba: helping turn abuse around for inmates

This investigation is an empirical evaluation of Esuba, an abuse awareness program implemented in the Florida correctional system. Research has indicated a link between violent and abusive behavior and criminal activity. This study specifically addressed whether the Esuba program had an impact on offenders' self-esteem, stability of self, faith in people, and sensitivity to criticism as measured by the Rosenberg Self-Esteem Scale. The results from the application of the Esuba program to an incarcerated offender population are encouraging. The results suggest that the Esuba program does appear to significantly increase offenders' emotional self-preservation.     

Introduction to Special Issue on the Institutional Balance and the Future of EU Governance: The Future of the Union and the Trap of the "Nirvana Fallacy"

The question of the "institutional balance" strikes at the very core of what the European Union is and where it is headed. In Declaration 23 of the Treaty of Nice, member states committed themselves to launching "a deeper and wider debate about the future of the Union" (point 3). As the articles in this volume indicate, in addressing the future of the Union, it is crucial that member states and the institutions dispel the myths upon which some of the need for reform has been conceived. In any institutional reform process, it is vital that the architects of reform avoid what Demsetz has referred to as the "Nirvana fallacy." In examining the institutional balance(s) in the EU and addressing the future of the Union, it is important that the realities of contemporary praxis are fully understood and that unrealistic goals are avoided. The EU can no more be expected to conform to some mythical ideal of "good governance" than can the member states of which it is constituted.     

What determines the value of life? a meta‐analysis

A large literature has developed in which labor market contracts are used to estimate the value of a statistical life (VSL). Reported estimates of the VSL vary substantially, from less than $100,000 to more than $25 million. This research uses meta‐analysis to quantitatively assess the VSL literature. Results from existing studies are pooled to identify the systematic relationships between VSL estimates and each study's particular features, such as the sample composition and research methods. This meta‐analysis suggests that a VSL range of approximately $1.5 million to $2.5 million (in 1998 dollars) is what can be reasonably inferred from past labor‐market studies when “best practice” assumptions are invoked. This range is considerably below many previous qualitative reviews of this literature. © 2002 by the Association for Public Policy Analysis and Management.     

Responsive bureaus,equity, and regulatory negotiation: an empirical view

Rulemaking agencies commonly delegate the implementation and enforcement of rules to affected parties, but they rarely delegate rulemaking authority. Regulatory negotiation is an example of this uncommon behavior. Compared to conventional rulemaking, regulatory negotiation is thought to be an attempt to make bureaucracy more responsive to affected stakeholders, especially when the rulemaking concerns politically complicated and technical issues. However, negotiation, while it may make bureaucrats more responsive, may also be less fair in that it is likely to result in relatively more responsiveness to interests supported by those with greater resources. This study presents empirical evidence that compares negotiated to conventional rulemaking processes at the Environmental Protection Agency in respect to both responsiveness and equality. The results uphold the expectation that negotiating rules appears more responsive than the conventional rule‐writing process. Furthermore, the results show inequality in both processes; outcomes of negotiated rules may be more unequal than outcomes of conventionally written rules. © 2002 by the Association for Public Policy Analysis and Management.     

Community Development Block Grant Spending Revisited: Patterns of Benefit and Program Institutionalization

This article analyzes Community Development Block Grant (CDBG)spending by local governments between 1988–1992. We addressfour issues examining actual expenditure patterns in a smallcentral city and five satellite cities in Michigan: changesin CDBG expenditure patterns; levels of social targeting; theextent of institutionalization of expenditure patterns; andthe level of privatization of CDBG spending. We conclude thatwhile spending for housing and public works is related to thefiscal health of cities, expenditures for economic developmentand social services are related to political characteristics.Further, local governments exceed federal social targeting guidelines.Finally, while there is little privatization, the communitiesstudied evidence modest levels of program innovation in thelater years of the CDBG program.     

Book reviews

Karl‐Eugen Wädekin, Sozialistische Agrarpolitik in Osteuropa. II. Entwicklung und Probleme. 1960–1976. Berlin: Duncker & Humblot, 1978. 338 pp. DM62.

Peter Vanneman, The Supreme Soviet: Politics and the Legislative Process in the Soviet Political System. Durham, North Carolina: Duke University Press, 1977. xii + 256 pp. $11.75.

I. S. Koropeckyj (ed.). The Ukraine within the USSR: An Economic Balance Sheet. New York: Praeger Publishers, and London: Martin Robertson, 1977. xxi +316 pp. £14.85.

Dorothy Atkinson, Alexander Dallin, Gail Warshofsky Lapidus (eds.), Women in Russia. Hassocks, Sussex: Harvester Press, 1978. viii+410 pp. £11.50.

J. Wilczynski, Comparative Monetary Economics. London: Macmillan, 1978. x + 270 pp. £12.00.

David Turnock, Eastern Europe Studies in Industrial Geography. Kent: Dawson Publishing/Westview Press, 1978. xi+273 pp. £9.50.

Edward Allworth (ed.), Nationality Group Survival in Multi‐Ethnic States: Shifting Support Patterns in the Soviet Baltic Region. New York: Praeger Publishers, and London: Martin Robertson, 1977. xiv + 299 pp. £14.40.

Robert Conquest, Kolyma—the Arctic Death Camps. London: Macmillan, 1978. 256 pp. £6.95.

Vladimir G. Treml (ed.), Studies in Soviet Input‐Output Analysis. New York: Praeger Publishers, and London: Martin Robertson, 1977. xx + 448 pp.

Richard Hennessy, The Agrarian Question in Russia 1905–1907. The Inception of the Stolypin Reform. (Marburger Abhandlungen zur Geschichte und Kultur Osteuropas, Band 16.) Giessen: Wilhelm Schmitz Verlag, 1977. 203 pp.     

“It's not Fair!” Adolescents' Constructions of Appropriateness of Parental Reactions

Research suggests that perceived appropriateness of parental discipline plays a role in whether adolescents accept or reject parental messages, but little is known about how adolescents conceptualize or construct their ideas of appropriateness. One hundred twenty-two adolescents (M age = 16.87) answered questions about past situations (both antisocial and prosocial), how parents responded to these situations, the adolescent's perceived appropriateness of the parent's reaction, how the parent's reaction made the adolescent feel, and what the adolescent thought the parent's intentions were. Appropriateness ratings were related to the type of parental discipline used, with yelling associated with lower ratings of appropriateness and talking associated with higher ratings. Ratings were also related to adolescents' emotions, with negative emotions associated with lower ratings of appropriateness and positive emotions associated with higher ratings. Lastly, ratings were related to adolescents' perceptions of parental intent, with inhibiting and controlling intentions associated with lower ratings of appropriateness and caring and helping intentions associated with higher ratings.