Review of analytical methods for screening and quantification of fentanyl analogs and novel synthetic opioids in biological specimens

Fentanyl, fentanyl analogs, and other novel synthetic opioids (NSO), including nitazene analogs, prevail in forensic toxicology casework. Analytical methods for identifying these drugs in biological specimens need to be robust, sensitive, and specific. Isomers, new analogs, and slight differences in structural modifications necessitate the use of high-resolution mass spectrometry (HRMS), especially as a non-targeted screening method designed to detect newly emerging drugs. Traditional forensic toxicology workflows, such as immunoassay and gas chromatography mass spectrometry (GC–MS), are generally not sensitive enough for detection of NSOs due to observed low (sub-μg/L) concentrations. For this review, the authors tabulated, reviewed, and summarized analytical methods from 2010–2022 for screening and quantification of fentanyl analogs and other NSOs in biological specimens using a variety of different instruments and sample preparation approaches. Limits of detection or quantification for 105 methods were included and compared to published standards and guidelines for suggested scope and sensitivity in forensic toxicology casework. Methods were summarized by instrument for screening and quantitative methods for fentanyl analogs and for nitazenes and other NSO. Toxicological testing for fentanyl analogs and NSOs is increasingly and most commonly being conducted using a variety of liquid chromatography mass spectrometry (LC–MS)-based techniques. Most of the recent analytical methods reviewed exhibited limits of detection well below 1 μg/L to detect low concentrations of increasingly potent drugs. In addition, it was observed that most newly developed methods are now using smaller sample volumes which is achievable due to the sensitivity increase gained by new technology and new instrumentation.     

The Cost of Terrorism: The Relationship Between International Terrorism and Democratic Governance

After Al Qaeda's destruction of the World Trade Center on 11 September 2001, many democracies reacted to the event, and to international terrorism in general, by passing laws restricting civil liberties and political rights, raising questions about the balance between security and liberty. Such laws have produced alarms among civil libertarians, worldwide. Are the alarms justified? In this article we analyze the relationship between the yearly number of international terrorist attacks in 24 countries from 1968–2003 and (a) measures of civil liberties and political rights as provided by Freedom House, and (b) levels of democracy as measured in the Polity IV scales. We take the number of international terrorist events, by country, from data provided by the Memorial Institute of the Prevention of Terrorism (MIPT) http://www.tkb.org/Home.jsp. Our analysis indicates that there is, generally, no relationship between the number of international terrorist events and the levels of civil rights, political rights, or democracy as measured by the Freedom House and Polity IV indicators. When there is a statistically significant relationship, it is negative, opposite to what is predicted by the tradeoff hypothesis.     

‘Like gold with yield’: evolving intersections between farmland and finance

Since 2007, capital markets have acquired a newfound interest in agricultural land as a portfolio investment. This phenomenon is examined through the theoretical lens of financialization. On the surface the trend resembles a sort of financialization in reverse – many new investments involve agricultural production in addition to land ownership. Farmland also fits well into current financial discourses, which emphasize getting the right kind of exposure to long-term agricultural trends and ‘value investing’ in genuinely productive companies. However, capital markets' current affinity for farmland also represents significant continuity with the financialization era, particularly in the treatment of land as a financial asset. Capital gains are central to current farmland investments, both as a source of inflation hedging growth and of potentially large speculative profits. New types of farmland investment management organizations (FIMOs) are emerging, including from among large farmland operators that formerly valued land primarily as a productive asset. Finally, the first tentative steps toward the securitization of farmland demonstrate the potential for a much more complete financialization of farmland in the future.     

Effets de l'irradiation X sur les chenilles de Bombyx mori dans diverses conditions d'alimentation et de jeune

Résumé Nous modifions le cycle nutritionnel des chenilles deBombyx mori, durant les premières 24 heures des deux premiers ages larvaires, avant ou après irradiation X. La chenille avant toute alimentation est très radiorésistante, le je?ne ne modifie pas cette radiorésistance. Suivant le moment du cycle physiologique (lorsque celui-ci est enclenché) où le je?ne est imposé, il diminuera ou augmentera la radiosensibilité des chenilles.

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Summary Silkworms (Bombyx mori) were exposed to irradiation in the 1st and 2nd larval instars. The effects, as indicated by mortality or by failure to moult, were studied in relation to a period of starvation (24 h at 22°). Before the initiation of feeding, in either instar, the larvae were very resistant to irradiation; and fasting did not modify this resistance. Probably this was due to physiological quiescence. After the initiation of feeding, the interposition of a fast either augmented or decreased radiation tolerance, probably according to the phase of the physiological cycle involving feeding and moulting.

     

The eleventh plateau: The lost object(ive) of legal education

Thanks to Peter Goodrich for commenting on an earlier version of this essay.     

The Role of Budget and Financial Reform in Making Government Work Better and Cost Less

Budgeting and Financial Management play a crucial role in organizing and disciplining the federal management culture. Consequently, addressing improvements in their practice is essential in the National Performance Review's examination of government-wide management systems. This article briefly describes the recommendations and anticipated implementing actions relating to budgeting and financial management within the context of the National Performance Review's themes of cutting red tape, putting customers first, empowering employees to get results, and cutting back to basics. External factors, such as innovations in private sector management practices, rapid changes in information technology, and statutory reforms such as the Government Performance and Results Act, also influence needed changes in budgetary and financial management practices.