Identification of anhydroecgonine ethyl ester in the urine of a drug overdose victim

Toxicological evaluation of postmortem urine collected from a 41-year-old deceased white male detected anhydroecgonine ethyl ester (ethylecgonidine, AEEE), a transesterification product of smoked cocaine co-abused with ethanol. A solid phase extraction (SPE) method was used to extract cocaine, AEEE, and related metabolites from urine. SPE on a 1 mL urine sample from the decedent followed by GC-MS detected AEEE. Other metabolites identified by GC-MS included cocaine, cocaethylene, and anhydroecgonine methyl ester (AEME). To determine whether some or all of the AEEE was artifactually produced in the heated GC injector port, an alternative LC-MS method was developed. LC/MS following SPE found at least 50 ng/mL of AEEE in the extract. The mass fragmentation (MS/MS and MS3) of AEEE detected in the urine was compared to spectra of authentic, synthesized compound. AEEE is a potential additional forensic marker for the co-abuse of smoked cocaine and ethanol.     

Organized crime in Ukraine: Challenge and response

Organized crime in Ukraine has helped to derail the transition to a democratic polity and a free market economy, has generated considerable violence and corruption, and has contributed significantly to the development of a climate that does little to encourage foreign direct investment. Consequently this article explains why Ukraine, along with other states of the Former Soviet Union, developed a major organized crime problem during the 1990s. Having done this, it delineates some of the major contours of organized crime in Ukraine, identifying the major participants in organized crime, the variations in the phenomenon in different cities and regions, and the major activities of organized crime. The article also examines the kinds of initiatives that have been taken by the government of Ukraine in its efforts to combat organized crime, before suggesting some areas in which these efforts could be significantly improved.     

R.S. Thomas: Ministering Otherness

This article is built around a deeply personal `response to text' –of a poem in response to a poem, where both deal with notions of identity. For myself, writing poetry is a cathartic (though infrequent) source of resolution; a space subject to different constraints from those present in the production of analytic scholarship. A consideration of the broader ideological matrix at work behind the poems suggests links between nationhood and language, class and religion, private and public identity, history and politics. Vast subjects, explored but briefly in the thoughts and notes produced for this article as `background' to the story of the poem cited at the end. For legal and political theory it is a reminder of the delicate interstices of influences traversed in any assertion concerning broad policy. As `scholar' I am constrained in the provision of any further assessment of my own process as `poet': what is provided attempts honesty. This revised version was published online in August 2006 with corrections to the Cover Date.