A rapid method for the determination of cocaine in brain tissue.

A rapid procedure is described for the extraction and analysis of brain samples for cocaine and benzoylecgonine. Human brain tissue was sectioned at autopsy, and samples were subjected to a lipase digestion, subsequent to solid-phase extraction. The distribution of cocaine and benzoylecgonine throughout different regions of the brain was determined by high-performance liquid chromatography.     

On National Self-determination

This paper argues in favour of a conception of self-determination which involves the equal recognition of different national identities. It proceeds by, first, criticizing the dominant territorial (in contrast to national) conception of self-determination. It then addresses three main criticisms of a principle of national self-determination. These are (1) the argument from indeterminacy; (2) the argument from instability; (3) the problem of overlapping nationalities.     

Peril and promise: a survey of India's strategic relationship with Central Asia

This article outlines the growing importance of India's relations with the Central Asian region. In particular, it explores security, economic, and cultural dimensions of the relationship. Important considerations for India in dealing with Central Asia include terrorism, Islamic fundamentalism, energy security, and new export markets. Of equal gravity, however, is the nature of great power competition in the heart of Asia. The argument presented here is that India's relations with Central Asia are calculated to gain strategic depth in the region. However, relationships with Pakistan, the United States, and the Asian great powers tend to constrain these ambitions. The future direction of India's strategic relationships with Central Asia remains fluid.     

Installing management by objectives in a public agency: a comparison of Black and White managers, supervisors, and professionals

This paper explores the prediction of King and Bass (1974) that black managers and supervisors may be more reluctant than whites to accept management programs such as management by objectives. Data were collected from 77 black and 61 white managers and professionals of the City of Detroit transportation system (D-DOT), after they had been involved with MBO for almost one year. Analyses of t-test results indicate that blacks assessed MBO as more helpful in their individual jobs and more positive for the organization than their white counterparts. Explanations derived from the racial demographics of the organization, the MBO installation, and characteristics of MBO as a management process in public agencies are given.     

“Just give me a number!” Practical values for the social discount rate

A major reason the quality of cost‐benefit analysis (CBA) varies widely is inconsistent use of the social discount rate (SDR). This article offers guidance about the choice of the SDR. Namely, we recommend the following procedures: If the project is intragenerational (does not have effects beyond 50 years) and there is no crowding out of private investment, then discount all flows at 3.5 percent; if the project is intragenerational and there is some crowding out of investment, then weight investment flows by the shadow price of capital of 1.1 and then discount at 3.5 percent; if the project is intergenerational and there is no crowding out of investment, then use a time‐declining scale of discount rates; if the project is intergenerational and investment is crowded out, then convert investment flows during the first 50 years to consumption equivalents using a shadow price of 1.1, and then discount all of these flows at 3.5 percent, and discount all flows after the 50th year using time‐declining rates. We then compare current discounting practices of U.S. federal agencies with our estimates. Consistent use of the recommended rates would eliminate arbitrary choices of discount rates and would lead to better public sector decision‐making. © 2004 by the Association for Public Policy Analysis and Management.     

Behavior Problems in Children Exposed to Wife Abuse: Gender Differences

Family aggression patterns and behavior problems of children, aged 6-12, recruited from shelters for battered women (shelter group) were contrasted with three comparison groups of currently nonviolent families: two-parent, single-mother, and homeless. Girls who had been exposed to recent interparental wife abuse were predicted to show more internalizing and externalizing behavior problems than similarly exposed boys, based on recent literature. Homeless and shelter mothers reported the highest rates of parent-child aggression. Shelter girls obtained significantly higher total, internalizing and externalizing behavior problem ratings than shelter boys, and than two-parent and single-mother girls. Shelter boys obtained significantly higher internalizing ratings than two-parent boys. Shelter and homeless children were rated as having equivalent levels of behaviour problems. Across all groups, mothers' psychological adjustment was a better predictor of daughters' adjustment than that of sons. The study concluded that the assumption that preadolescent girls have greater immunity to psychosocial risk is unfounded.     

Elimination of 7-aminoflunitrazepam and flunitrazepam in urine after a single dose of Rohypnol

The hypnotic benzodiazepine flunitrazepam (Rohypnol) has been identified as the drug of choice for the purposes of "drugging" unsuspecting victims and raping them while they are under the influence of this substance. The objective of this paper was to study elimination of flunitrazepam and 7-aminoflunitrazepam in urine collected from ten healthy volunteers who received a single 2 mg oral dose of Rohypnol, to determine how long after drug administration 7-aminoflunitrazepam can be detected. A highly sensitive NCI-GC-MS method for the simultaneous quantitation of flunitrazepam (LOQ 100 pg/mL) and 7-aminoflunitrazepam (LOQ 10 pg/mL) in urine was developed. All samples were screened for benzodiazepines using optimized micro-plate enzyme immunoassay. The highest concentrations of 7-aminoflunitrazepam (70-518 ng/mL) and flunitrazepam (0.7-2.8 ng/mL) in urine were observed 6 h after drug administration in nine subjects and after 24 h in one subject. In six subjects 7-aminoflunitrazepam was detected up to 14 days after flunitrazepam administration, in one subject up to 21 days and in three subjects up to 28 days. In urine samples collected from six volunteers, flunitrazepam was detected three days after Rohypnol intake, in three subjects 24 h, and in one subject 5 days later. Benzodiazepine micro-plate enzyme immunoassay kit allowed the detection of flunitrazepam and metabolities 5 to 21 days after drug administration.