Fictitious Freedom: A Polanyian Critique of the Republican Revival

Prominent republican theorists invoke anonymous orders such as the market as mechanisms that secure freedom as non‐domination. Drawing on Karl Polanyi's account of fictitious commodities and demonstration of the impossibility of a just and rational market society, this article critically scrutinizes neo‐republican assumptions regarding the market, develops an alternate social theory within which to situate the ideal of non‐domination, and illustrates the importance of this reconfiguration for the kind of collective agents and political strategies that can be expected to advance republican freedom in the economy.     

Resorting to Statism to Find Meaning

The paper develops the idea of configuration of ownership to distinguish three primary political ideologies: (classical) liberalism, conservatism, and leftism. The liberal configuration is atomistic in its recognition of owners and ownership claims; it conforms closely to Adam Smith’s “commutative justice,” which Smith represented as a sort of social grammar. The conservative configuration also strives for a social grammar, but it counts among the set of owners certain spirit-lords such as God and Patria. The liberal and conservative configurations become isomorphic if and only if the ownership claims of the conservative spirit-lords are reduced to nothing. The left configuration ascribes fundamental ownership of resources to the people, the state, and sees laws as organizational house-rules into which one enters voluntary by choosing to remain within the polity; the type of justice that pertains is parallel to Smith’s “distributive justice,” which Smith associated with aspirational rules for achieving beauty in composition. The scheme illuminates why the left’s conception of liberty consists in civil liberties. The formulation of configurations is used to interpret the semantics of the three primary ideologies. Meanwhile, it is noted that actually existing parties and movements are admixtures of the three primary ideologies. For example, what makes Republicanism “conservative” is that it is relatively conservative; it by no means thoroughly or consistently rejects the precept of collective ownership by the polity.

Does contact with the justice system deter or promote future delinquency? Results from a longitudinal study of British adolescent twins

What impact does formal punishment have on antisocial conduct—does it deter or promote it? The findings from a long line of research on the labeling tradition indicate formal punishments have the opposite-of-intended consequence of promoting future misbehavior. In another body of work, the results show support for deterrence-based hypotheses that punishment deters future misbehavior. So, which is it? We draw on a nationally representative sample of British adolescent twins from the Environmental Risk (E-Risk) Longitudinal Twin Study to perform a robust test of the deterrence versus labeling question. We leverage a powerful research design in which twins can serve as the counterfactual for their co-twin, thereby ruling out many sources of confounding that have likely impacted prior studies. The pattern of findings provides support for labeling theory, showing that contact with the justice system—through spending a night in jail/prison, being issued an anti-social behaviour order (ASBO), or having an official record—promotes delinquency. We conclude by discussing the impact these findings may have on criminologists’ and practitioners’ perspective on the role of the juvenile justice system in society.     

Effect of ethanol on cardiac single sodium channel gating

Alcohol in modest and higher doses has the potential to induce cardiac arrhythmias. The most famous alcohol-related arrhythmia is the "holiday heart syndrome". Furthermore, there is a clear association between excessive alcohol consumption and the risk of sudden cardiac death. However, the acute effects of ethanol on arrhythmia induction are not well understood. The effect of ethanol on single cardiac sodium channels has not been studied yet. To elucidate the effect of ethanol on human cardiac sodium channels we performed a patch clamp study in HEK-293 cells overexpressing the human cardiac sodium channel. We used HEK-293 cells overexpressing the human cardiac sodium channel (Na(1.5)). Single channel gating was investigated by the cell-attached patch clamp technique. Sodium channel currents were elicited by depolarizing pulses from -120 to -20mV for a duration of 150ms. Single channel availability, open probability and peak average current were assessed baseline and after addition of ethanol in increasing concentrations (0.50 per thousand (10.9mM), 1.00 per thousand (21.7mM), 2.00 per thousand (43.5mM) and 4.00 per thousand (87.0mM)). We found a concentration-dependent reduction of open probability which was statistically significant at 2.00 per thousand ethanol (66.5+/-14% of control). At higher concentrations (4.00 per thousand) also availability decreased to 66.5+/-11.0% of control. This resulted in a significant decrease of peak average current at 2.00 per thousand and at 4.00 per thousand ethanol (61.8+/-7.4 and 53.0+/-8.2% of control). For the first time the present study demonstrates acute inhibitory effects of ethanol on single cardiac sodium channel gating and provides one potential mechanism for the well known clinical observation that ethanol triggers supraventricular and ventricular arrhythmias.     

Mass spectral and NMR spectral data of two new designer drugs with an alpha-aminophenone structure: 4'-methyl-alpha-pyrrolidinohexanophenone and 4'-methyl-alpha-pyrrolidinobutyrophenone

This study presents and discusses the nuclear magnetic resonance (NMR) spectroscopic and mass spectroscopic data of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone (MPBP) and its homolog 4'-methyl-alpha-pyrrolidinohexanophenone (MPHP) which were seized in 2004 and 2000 in Germany for the first time. The structure elucidation of the aliphatic part of MPBP was carried out by product ion spectroscopy of the immonium ion formed after electron ionization as well as with 1H and 13C NMR. Product ion spectroscopy of immonium ions again proved to be a powerful tool to determine the structure of designer drugs and to distinguish between isobaric structures of the alkyl-amino moiety.