Stability study of the designer drugs "MDA, MDMA and MDEA" in water, serum, whole blood, and urine under various storage temperatures.

A controlled study was undertaken to determine the stability of the designer drugs MDA, MDMA and MDEA in pooled serum, whole blood, water and urine samples over a period of 21 weeks. The concentrations of the individual designer drugs in the various matrices were monitored over time, in the dark at various temperatures (-20, 4 or 20 degrees C), for a low (+/- 6 ng/ml for water, serum and whole blood and +/- 150 ng/ml for urine) and a high concentration level (+/- 550 ng/ml for water, serum and whole blood and +/- 2500 ng/ml for urine). Compound concentrations were measured using a validated HPLC assay with fluorescence detection. Our study demonstrated no significant loss of the designer drugs in water and urine at any of the investigated temperatures for 21 weeks. The same results were observed in serum for up to 17 weeks, and up to 5 weeks in whole blood. After that time, the compounds could no longer be analyzed due to matrix degradation, especially in the low concentration samples that were stored at room temperature. This study demonstrates that the designer drugs, MDA, MDMA and MDEA are stable when stored at -20 degrees C for 21 weeks, even in haemolysed whole blood.     

Governance by Proxy: A Comparative Policy Analysis of the Mainstreaming of Immigrant Integration Governance

Abstract

This paper assesses mainstreaming as a governance strategy that potentially addresses the call for a more integral governance response to wicked policy problems. Our comparative qualitative policy analysis of the mainstreaming of immigrant integration governance contributes to the governance and mainstreaming literature by emphasizing the importance of strong horizontal and vertical coordination mechanisms and the distinction between universal and proxy targeting in mainstreaming. Although policy programmes indeed seem to broaden to a universal mainstreamed approach, in practice they often operate by “proxy”. Furthermore, horizontal coordination structures tend to be weak or not in place at all, again obstructing the embedding of immigrant integration as a mainstreamed cross-cutting governance issue.     

Physical stature and biological living standards of girls and young women in the Netherlands,born between 1815 and 1865

This is the first study in Dutch anthropometric historiography that describes and analyzes the development of the biological standard of living of girls and young women from the perspective of female adult stature. It is shown that adult stature of women, imprisoned in the second half of the nineteenth century and born between 1815 and 1865, slightly increased, approximately 1 cm. From 1850 onwards stature of women born in the cities notably increased. Development of female adult stature was compared to that of male stature; both were quite similar. No circumstantial evidence was found that girls or young women were on a disadvantage with respect to nutrition and (medical) care.     

美欧关系

21世纪初的国际体系从根本意义上讲是单极体系,美国作为唯一的超级大国,凭借其超强的经济、军事实力主导国际事务。在未来的10-20年内,这一单极体系仍将维持下去,多极体系的形成尚待时日。美欧双方虽然在意识形态、文化上具有很大同质性,但随着国际形势的新发展,美欧分歧会越来越多,但直接冲突的可能较小。     

The Making of International Law

Netherlands International Law Review -