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61.
Paneto GG Martins JA Longo LV Pereira GA Freschi A Alvarenga VL Chen B Oliveira RN Hirata MH Cicarelli RM 《Forensic science international》2007,173(2-3):117-121
The analysis of mitochondrial DNA (mtDNA) is a useful tool in forensic cases when sample contents too little or degraded nuclear DNA to genotype by autosomal short tandem repeat (STR) loci, but it is especially useful when the only forensic evidence is a hair shaft. Several authors have related differences in mtDNA from different tissues within the same individual, with high frequency of heteroplasmic variants in hair, as also in some other tissues. Is still a matter of debate how the differences influence the interpretation forensic protocols. One difference between two samples supposed to be originated from the same individual are related to an inconclusive result, but depending on the tissue and the position of the difference it should have a different interpretation, based on mutation-rate heterogeneity of mtDNA. In order to investigate it differences in the mtDNA control region from hair shafts and blood in our population, sequences from the hypervariable regions 1 and 2 (HV1 and HV2) from 100 Brazilian unrelated individuals were compared. The frequency of point heteroplasmy observed in hair was 10.5% by sequencing. Our study confirms the results related by other authors that concluded that small differences within tissues should be interpreted with caution especially when analyzing hair samples. 相似文献
62.
Raposo VL 《European journal of health law》2012,19(4):379-390
Some years ago the doctor was seen as the one who "knows better", and it was absolutely unconceivable that the patient could refuse the suggested treatment or even ask any questions about it. Differently, nowadays doctors face demands to keep their patients informed and can even be sued when they act without patient knowledge and consent. On the patient's side this new paradigm does not necessarily legitimate euthanasia--still criminally forbidden in most parts of the world--but allows some kind of personal power over body, health and life, materialized in advance directives. On the doctor's side, it entails a change in the list of good medical practices, imposing the doctrine of informed consent and the prohibition of dysthanasia. 相似文献
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Hellen P. Gross Julia Thaler Vera Winter 《International Public Management Journal》2019,22(1):176-206
Public service motivation (PSM) is a focal construct in public management research, and while sound evidence exists that PSM is positively associated with several desired outcomes, knowledge on the underlying mechanisms which explain these associations and on potential negative consequences of PSM remains limited. Addressing these research gaps, this study investigates how PSM relates to relational job resources, work engagement, and outcomes. We thereby account for both direct and moderating effects of PSM and consider positive (employee performance) and negative outcomes (sickness absenteeism and presenteeism). We empirically test our model in the German public sector and find that the PSM dimensions relate differently to the assessed outcomes, providing varying support for our hypotheses. In particular, commitment to public value and compassion seem to drive the positive effect of PSM on employee performance, whereas self-sacrifice and client orientation are linked to reduced absenteeism, and only compassion is associated with increased presenteeism. 相似文献
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Vera McEwan 《Education & the Law》2001,13(1):43-50
The system of teacher induction appeals as introduced by the Teaching and Higher Education Act 1998 is yet to be fully implemented. The appeals system envisaged by both the Act and subsequent regulations is still evolving and matters are made more complex by the fact that the appeals will be part of the General Teaching Council's (GTC) functions in due course. The Department for Education and Employment has had the unenviable task of drafting detailed procedures which may, or may not, be adopted by the GTC. The department's system of appeals may only apply for six months before the GTC review which may not be time enough to properly evaluate the various procedures. This article attempts to set out the current procedure and to offer some thoughts on areas which may need to be carefully monitored by both the department and the GTC. 相似文献
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Vera Hajt 《The History of the Family》2009,14(2):203-216
Transnational adoption and child migration are often regarded as recent phenomena, yet there is a long history of children travelling without their families, settling and integrating in a foreign culture and environment. In the 1920s, thousands of Hungarian children went to Belgium for a six-month holiday within the framework of a humanitarian project. Although they were supposed to return to Hungary after their vacation, some of them stayed indefinitely with their Belgian families. By analyzing oral testimonies of the now elderly ‘children’ about their migration and childhood experiences in Belgium, we explore how they construct and reconstruct concepts such as childhood, vulnerability, and loyalty commitments, and show the crucial importance of maintaining birth family ties for the future development of transnationally adopted children. 相似文献
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