Relationships between concentrations of cocaine and its hydrolysates in peripheral blood, heart blood, vitreous humor and urine

Cocaine is known to degrade in vivo and in vitro by several hydrolytic mechanisms. A previous study found that the initial amount of cocaine added to plasma could be accounted for by summing the molar concentrations of cocaine's hydrolysis products and the cocaine remaining after hydrolysis. The present study was undertaken to investigate whether or not relationships might exist between such molar concentration sums for different postmortem bodily fluids. Determinations of cocaine, benzoylecgonine, ecgonine methyl ester, and ecgonine were performed using liquid chromatography/mass spectrometry (LC/MS/MS) with heart blood, femoral blood, vitreous humor (VH), and urine (UR). The results demonstrate a strong correlation between blood and VH concentrations (correlation coefficients of 0.88-0.94), weak correlation between the UR and blood concentrations (correlation coefficients of 0.61-0.64), and weak correlation between UR and VH concentrations (correlation coefficient of 0.59). The results demonstrate that ecgonine is a significant hydrolysate with concentrations on the same order of magnitude as benzoylecgonine. The results are consistent with rapid distribution of the parent drug and its hydrolysates in the blood and VH. The strong correlation between the blood and VH demonstrates that VH is an important medium for toxicology testing when attempting to make a determination of cocaine intoxication.     

Taphonomy of child-sized remains: a study of scattering and scavenging in Virginia, USA

Child-sized pig carcasses (Sus scrofa) were placed in surface deposit and buried scenarios in a wooded area of Virginia from May 1998 through December 2000, to examine the taphonomic effects of decompositional changes, predator scavenging, and the extent of remains scattering. Changes were observed through on-site examination, charting of remains, and recorded video imaging. Analysis of data revealed that utilization of corpses as food sources by vertebrates was dependent upon invertebrate colonization. Vertebrates avoided feeding on the corpses while invertebrate colonization was active, and would feed before invertebrates successfully colonized a corpse, or would wait until the invertebrate populations migrated away from the corpse. Among vertebrates, there was no apparent succession order for the animals utilizing the remains as a food source. Different vertebrates would feed at different times based upon diurnal or nocturnal predilection. Analysis noted an accidental cooperative relationship between the invertebrates and vertebrates scavenging on the corpses. Certain vertebrates gained access to the internal tissues by utilizing openings in the corpses caused by invertebrate and other vertebrate scavenging. Alternately, carrion-frequenting insects were afforded access to previously inaccessible colonization sites as a result of scavenging vertebrate activities.     

Scaling legislative decision making: A methodological exercise

Previous work in American state politics shows that an accurate measure of legislative decision-making attributes can be a useful tool for empirical research. Using data from a new survey of state legislators, conducted in 1981, the present analysis includes both an improved survey item and a sophisticated scaling procedure.     

The Rise and Fall and Rise Again of Public Broadcasting? The Case of the Australian Broadcasting Corporation

The purported capacity of the digital age to solve the problem of market failure in the broadcasting sector was widely expected to further compromise the already fragile status of public service broadcasting in advanced democracies. The proliferation of niche media content made possible by convergence led to speculation that publicly funded broadcasters would be rendered redundant. However while public service broadcasting in Australia and in comparable states remains under financial pressure, many signs point to a renewed government commitment to the sector. Using the Australian Broadcasting Corporation as our case study we argue that the digital era has contributed to the renaissance of the sector in unexpected ways.     

Organizational Readiness for Change in Correctional and Community Substance Abuse Programs

Significant needs exist for increased and better substance abuse treatment services in our nation's prisons. The TCU Organizational Readiness for Change (ORC) survey has been widely used in community-based treatment programs and evidence is accumulating for relationships between readiness for change and implementation of new clinical practices. Results of organizational surveys of correctional counselors from 12 programs in two states are compared with samples of community-based counselors. Correctional counselors perceived strong needs for new evidence-based practices but, compared to community counselors, reported fewer resources and less favorable organizational climates. These results have important implications for successfully implementing new practices.     

Whatever Happened to the Australian Role in the Global Nuclear Energy Partnership?

In 2003, Iraq was invaded, ostensibly to remove a nuclear threat, by a coalition led by George W. Bush. At the same time select allies were invitited to participate in Bush's Global Nuclear Energy Partnership which aimed to limit the spread of nuclear enrichment and reprocessing. This came as climate change gave emphasis to the development of nuclear energy, especially in Asia. With an abundant supply of uranium and strict nuclear safeguards, Australia was well placed to provide a site for the full suite of nuclear services. The recent AUKUS nuclear submarine agreement has underscored its failure to do so. This article makes the case for the adoption of nuclear power as a necessary step in the development of advanced manufacturing; the provision of a domestic capability to fuel nuclear attack submarines and other naval craft; and as a contribution to global nuclear non-proliferation.     

Permission to speak: British women in the established churches during the First World War

The first decade of the twentieth century witnessed the growth of the suffrage movement, and a vigorous debate about the public role of women. Britain’s established churches were caught up in this discussion, as they addressed calls for women to have more authority in religious institutions. Dialogue among church leaders ranged between two extremes. Conservatives viewed women’s roles through the lens of ‘traditional’ gender constructs, opposing a public role and voice for women. Progressive factions contended that women should receive the political suffrage and the right to participate in church councils. The male hierarchy argued that empowered women were necessary for the ongoing ministries of the churches, and would be supportive of traditional morality. By 1919, the progressives had prevailed. This matched developments in the franchise, in which gendered qualifications for voting were swept away. Thus, the typically conservative churches played an important role in redefining women’s public roles.     

Changing contexts: A quasi-experiment examining adolescent delinquency and the transition to high school

In a quasi-experiment, we examine whether changing schools during the transition from 8th to 9th grade influences adolescent delinquency, using a sample of more than 14,000 students in 26 public school districts (PROSPER study). The dataset follows students for eight waves from 6th through 12th grade and facilitates a unique, direct comparison of students who change schools with those who remain in the same school during this period. Results show that students who transition between schools report significantly less delinquency after the shift than those who do not, and that this difference persists through 10th grade. This decline is most pronounced when adolescents from multiple middle schools move to a single high school (i.e., multifeeder transitions). Students who transition between schools have fewer delinquent friends and participate in less unstructured socializing following the change in school environment, which partially mediates their reduced delinquency. Results provide some support for theories of differential association and routine activities. Our findings highlight the role of a crucial, yet understudied, life transition in shaping adolescent delinquency. The results from this quasi-experiment underscore the potential of alterations in social context to significantly dampen juvenile delinquency throughout high school.