1H nuclear magnetic resonance of heroin's D ring

The 1H nuclear magnetic resonance (NMR) chemical shifts and coupling constants of heroin's D ring H-15 alpha, H-15 beta, and H-16 alpha, and H-16 beta are presented. These assignments were accessible through the introduction of a double bond (delta 15,16) in heroin. The resulting compound, delta 15,16 didehydroheroin, was subjected to deuterium exchange or stereoselective reduction or both. Reduced products d1-16 alpha heroin d2-15 alpha, 15 beta-heroin, and d3-15 alpha, 15 beta, 16 alpha-heroin are presented. Heroin with deuterated acetyls is also presented for 1H NMR spectral clarity in the D ring area.     

Police supervision on the street: An analysis of supervisor/officer interaction during the shift

This article examines a major assumption of street supervisors in police agencies—that control of police officer behavior is dependent on strict hierarchical organization. The intellectual roots of this assumption are examined, and an emerging perspective developed from direct observation of patrol operations is presented. The research questions are addresses with data that were collected from observations of patrol activities in 60 residential neighborhoods in 24 agencies. The analysis, which is referenced to officers' shifts of duty, shows that the effect of supervision is in the direction posited by the authors of traditional police administration texts, but the magnitude of the effect is not overly strong. The findings are used to inform the evaluation of a common policy option directed at improving officer performance through supervision.     

Consistency in policy thinking

This study examines consistency in opinion on a variety of important state and national policy questions. The data come from a two-wave panel study of adult Floridians conducted in 1981 and 1982. Wide variations in consistency of opinion over the 1-year period are found. Salience has an important impact on consistency, with respondents who find an issue salient almost always exhibiting more consistent opinions, but salience cannot explain the variations in consistency across issues. The level of government on which the issue is focused (national or state) has no bearing on consistency. Most important, the particular nature of the issue itself, especially how central it is to the individual and how long it has occupied the political agenda (maturity), affects consistency of opinion. Centrality and maturity both contribute to issue attitude consistency and even can compensate for one another. Both highly central new issues and remote old issues can produce consistent attitudes, but deficiences in centrality seem to override issue maturity. These findings illustrate the value of looking beyond opinion distributions to the meaning of the survey response. With information on consistency and its sources, the public opinion analyst can interpret polling results intelligently, and the study of public opinion can become more objective and scientific.     

Correlates of outcome following acute glutethimide overdosage

Potential predictors of outcome following acute glutethimide overdosage were assessed in 63 patients hospitalized with this diagnosis at a large urban medical center between 1962 and 1975. Their mean age was 34 years (range, 15 to 84 years) and 62% were female. Assisted ventilation was required in 59% of cases, and 32% developed hypotension. Six patients died, including all three aged 60 years or older. Multiple regression analysis confirmed that age was the major identifiable determinant of survival, regardless of other factors. Among identifiable determinants of coma grade, glutethimide dose, glutethimide plasma concentration, and coingestion of barbiturates were the most important. An ingested dose of 10 g or more, or a plasma concentration exceeding 30 microgram/ml, was almost always associated with deep coma. However, a relatively small ingested dose or a low plasma level by no means ruled out development of serious intoxication, particularly in those patients who also ingested barbiturates. Thus elderly individuals are at high risk for fatal outcome following glutethimide overdosage and should receive priority for intensive care and monitoring. Glutethimide dose, plasma concentration, and history of coingestion of barbiturates are of value in predicting development of deep coma. These items of information should be obtained on admission whenever possible.