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171.
Managing incidental findings in human subjects research: analysis and recommendations. 总被引:8,自引:8,他引:0
Susan M Wolf Frances P Lawrenz Charles A Nelson Jeffrey P Kahn Mildred K Cho Ellen Wright Clayton Joel G Fletcher Michael K Georgieff Dale Hammerschmidt Kathy Hudson Judy Illes Vivek Kapur Moira A Keane Barbara A Koenig Bonnie S Leroy Elizabeth G McFarland Jordan Paradise Lisa S Parker Sharon F Terry Brian Van Ness Benjamin S Wilfond 《The Journal of law, medicine & ethics》2008,36(2):219-48, 211
No consensus yet exists on how to handle incidental findings (IFs) in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are findings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. 相似文献
172.
The Trade Union Movement and the European Union: Judgment Day 总被引:1,自引:0,他引:1
Brian Bercusson 《European Law Journal》2007,13(3):279-308
Abstract: The trade union movement faces a challenge to the legality of transnational collective action as violating economic freedoms in the EC Treaty. How are disparities in wages and working conditions among the Member States to be accommodated? Are national social models protected? Does the internal market allow for trade union collective action? How does EU law affect the balance of economic power in a transnational economy? What is the role of courts in resolving economic conflicts? This article analyses the responses to these questions as referred to the European Court of Justice by the English Court of Appeal and offers some conclusions. The purpose is to highlight the different positions adopted by the old Member States and the new accession Member States as regards the underlying substantive issues, and the options available to the Court of Justice in answering the questions posed. 相似文献
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Abstract. Direct democratic institutions, while centrepieces of the Swiss political system, find themselves under attack. In this article, we challenge the widespread criticism that popular rights increasingly limit the political elite's control of the decisionmaking process. Our analysis is based on aggregate data of all acts voted on by the Swiss Parliament since 1947 – those brought about by popular initiatives or those subject to optional and mandatory referendum – and on individual survey data on most federal votes held since 1981. We underline the high support of government and the impact of elite consensus on the destiny of legislative acts in the plebiscitary phase (submitted to a vote or not, subsequently accepted or not). While congruent with the aggregate analysis, results obtained at the individual level are less clearcut. The influence of voting recommendations and information channels on the voter's decision appears rather weak. 相似文献
176.
Whitehead Brian; Jackson Stuart; Kempner Richard 《Jnl of Intellectual Property Law & Pract》2008,3(4):226-235
Legal context: The income streams of originating pharmaceutical manufacturersare under pressure as never before, from increasing R&Dcosts, regulatory pressures, and competition from generic manufacturers.This article examines the various strategies which originatingpharmaceutical manufacturers have adopted in response to thesethreats. Key points: The authors consider various strategies, including SupplementaryProtection Certificates, life-cycle management (evergreening),second pharmaceutical use claims, trade marks, and the use ofdata exclusivity and interim injunctions, in order to prolongthe protection given to existing products, and to manage competitionfrom generic manufacturers. Practical significance: The authors also include two real-life case studies in orderto illustrate the practical applications of the strategies discussedin the article. 相似文献
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Jeffrey C. Alexander 《Society》2010,47(5):410-418
Common knowledge suggests that elections are won or lost based on demographics, finances, and other structural elements. Whether
candidates win or lose, however, is a matter of action. Symbolic identification, metaphor, and an unfolding narrative—and
how they are managed and interpreted in the flow of events—determine who will emerge victorious from the democratic struggle
for power. The McCain campaign’s effort to cast Obama as a celebrity, with the hollow trivialities and self-aggrandizement
of Paris Hilton and Britney Spears, proves to be one of the most dangerous episodes for the Obama campaign. In response, the
Democrats must adjust the staging of Obama’s Thursday night acceptance speech in Denver as a performance of purpose and gravitas,
rather than glitz and adoration. 相似文献
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Concern about school violence has been escalating in recent years. A variety of strategies are used in efforts to prevent violence in schools. These remedies can be classified as legal, interactionist, and physical remedies. Legal remedies refer to laws, like the reasonable suspicion to search strategy that allows school officials to search and seize contraband. Interactionist remedies refer to practices that encourage students and other school officials to communicate more openly with school officials about possible cases of violence. Physical remedies refer to strategies that involve altering the school environment in an effort to prevent violence. This study considered the way that 138 school officials from the Commonwealth of Virginia defined the usefulness of these strategies. Attention was also given to whether certain factors contribute to the officials' assessments of the efficacy of each prevention strategy. Results of the study showed that the interactionist, and then legal remedies are believed to be the most useful, while physical remedies are perceived as the least useful strategies. The study uncovered differences of opinion based on racial lines. As an example, more Blacks than Whites were more likely to describe metal detectors as a very useful strategy. Implications of the study are provided. 相似文献