New alleles and mutational events at 14 STR loci from different German populations

The molecular origin of DNA mutations and the mutation rates were analyzed at 14 short tandem repeat (STR) loci with samples from trio cases derived from 10 different German population samples. STR loci comprised of D2S1360, D3S1744, D4S2366, D5S2500, D6S474, D7S1517, D8S1132, D10S2325, D12S391, D18S51, D19S246, D20S480, D21S226, and D22S689. In a total of 488 meioses, 16 isolated genetic inconsistencies in 8 different STRs were observed, whereas no mutations were found at the other loci. The data of five mutations suggested the presence of silent or null alleles due to sequence variation in primer binding site. This could be confirmed for four suspected cases by the use of alternative primer sets and by DNA sequence analyses. Furthermore, this study revealed nine new allelic variants at five different loci.     

Distinct age-related differences among victims in cases of suspected child abuse

Evidence describing age-related differences among children with suspected physical and sexual child abuse is lacking. We describe findings in severe cases of suspected abuse. Cases with 756 children <15 years old were included during 2001–2013 at the Department of Forensic Medicine, Aarhus University, using forensic evaluation documents, medical records, and court proceedings. Eight percent of children <4 years old died from child abuse, 36% through violence resulting in death, and 64% by manslaughter, whereas 1% > 4 years old died, solely by manslaughter. External injuries were mainly located to head and torso in children <4 years old, changing to the upper and lower extremities in older children. Child sexual abuse was suspected in 52% of cases with living children <4 years old, 83% of children 4–7 years of age, 88% of children 8–11 years of age, and 93% of children >12 years old. Anogenital findings were mainly caused by other medical conditions in children <4 years old, hymenal clefts in the superior half of the hymenal rim were almost exclusively found in children between 8 and 11 years of age, whereas both superficial and complete hymenal clefts in the inferior half of the hymenal rim were found in children >12 years old. The present study describes age-related differences in victims of suspected child abuse. Fatal versus nonfatal child physical abuse and the significance of hymenal findings in child sexual abuse could be studied further.     

Determinants of disproportionality and wasted votes

The aim of this article is to explain differences in disproportionality. The dependent variable has two components. One is the index of disproportionality created by Michael Gallagher (1991). The other component consists of the amount of wasted votes, i.e. votes that are given to representatives of parties which fail to gain representation in parliament. Three independent variables are used: district magnitude, electoral thresholds, and the combined measurement of these variables, namely the effective threshold. The test reveals that while Gallagher's index of disproportionality is affected by district magnitude and the effective threshold, the amount of wasted votes remains, with the possible exception of a weak link to electoral thresholds, unaffected by changes in the independent variables. Explanations for the findings are introduced and discussed.     

Exploring Contracts as Reinvented Institutions in the Danish Public Sector

Contracts have been on the agenda in public sector reform in most OECD countries. In Denmark, contracts have been considered as one of the most important tools in reorganizing the public sector. The article examines the implementation of contract agencies in central government in Denmark during the 1990s. First, a review of contractual theory distinguishes between 'hard' and 'soft' contracting. Second, recent developments in contracting in Denmark are examined, and three phases of contract agencies are identified. Contracts have been supported by other tools for reporting on performance like annual reports. Third, it is argued that Denmark has put co-operation and negotiation before more strict management and control. The Danish experience can be seen as an alternative to the principal-agent model. The article finishes by discussing the pros and cons of the Danish approach, and suggests that although the pragmatic approach has merits, it may lead to problems in the future concerning the credibility of the whole project.     

Analysis of ecstasy tablets: comparison of reflectance and transmittance near infrared spectroscopy

Calibration models for the quantitation of commonly used ecstasy substances have been developed using near infrared spectroscopy (NIR) in diffuse reflectance and in transmission mode by applying seized ecstasy tablets for model building and validation. The samples contained amphetamine, N-methyl-3,4-methylenedioxy-amphetamine (MDMA) and N-ethyl-3,4-methylenedioxy-amphetamine (MDE) in different concentrations. All tablets were analyzed using high performance liquid chromatography (HPLC) with diode array detection as reference method. We evaluated the performance of each NIR measurement method with regard to its ability to predict the content of each tablet with a low root mean square error of prediction (RMSEP). Best calibration models could be generated by using NIR measurement in transmittance mode with wavelength selection and 1/x-transformation of the raw data. The models build in reflectance mode showed higher RMSEPs using as data pretreatment, wavelength selection, 1/x-transformation and a second order Savitzky-Golay derivative with five point smoothing was applied to obtain the best models. To estimate the influence of inhomogeneities in the illegal tablets, a calibration of the destroyed, i.e. triturated samples was build and compared to the corresponding data of the whole tablets. The calibrations using these homogenized tablets showed lower RMSEPs. We can conclude that NIR analysis of ecstasy tablets in transmission mode is more suitable than measurement in diffuse reflectance to obtain quantification models for their active ingredients with regard to low errors of prediction. Inhomogeneities in the samples are equalized when measuring the tablets as powdered samples.     

Research capacity building through twinning: experiences from a Danish–Malaysian twinning project

Twinning and its contribution to institutional capacity building in developing countries is the theme of an ongoing debate in Public Administration and Development. Unlike earlier contributions this article focuses on twinning in the context of research capacity enhancement. Using a 3 year Danish–Malaysian twinning research project as case our objective is to evaluate whether the general premises regarding a twinning project, as formulated by the Danish Development Cooperation Agency (Danida), appropriately support the twinning ambitions when the capacities in focus concern research. Besides institutional capacity building, twinning is expected to favour local ownership, involvement of the Danish resource base and continuing of cooperation after termination of funding. From 21 semi‐structured interviews with project participants it was found that although new research capacities had been gained, the prospects on continued cooperation are rather discouraging, both sides pointing to the lack of truly joint research experiences as the main reason. To care for this important incentive, the twinning premises are recommended to be modified to allow for the Northern resource base to advance its own research, and for Southern partner to demonstrate in‐house research capacities. Further, the North–South balance in project management needs to be more equal. This apart, the twinning premises appear sound. Copyright © 2007 John Wiley & Sons, Ltd.     

A European Security Policy? The Attitudes of Candidates for the European Parliament*

It has been argued that the credibility of the American nuclear deterrent is declining in Western Europe. Whether this is true or not, it seems clear that support for the NATO alliance had reached a remarkably low level among Western European political elites as the 1970s drew to a close. One possible alternative to continued reliance on the Atlantic Alliance would be for Western Europe to develop its own independent defence capabilities. Certainly, in terms of economic and technological resources, this option should be within reach of an integrated European Community. And indeed there seems to be widespread support among European political leaders for the principle of having Western Europe play a more independent role vis-à-vis both superpowers. But there is no clear consensus in favour of the increased defence expenditures that such a policy would entail. Nor is there a consensus in favour of developing a unified West European security system inside or outside the institutional framework of the European Community. Our evidence in support of these conclusions is based on interviews carried out with candidates for the European Parliament in all nine member countries during the months immediately preceding the first direct elections in June, 1979.