Demythologising the petite bourgeoisie: The Italian case

The political volatility and economic instability of the petite bourgeoisie are taken for granted in most political and sociological analysis. Viewed as a pivotal force in historic and contemporary movements of the extreme right, it is widely believed to exercise a constant ‘threat’ potential, thus guaranteeing its protection throughout the post‐war period — above all in the Italian context where small economic entrepreneurs persist in substantial numbers. Using a variety of evidence, including electoral and survey materials, this article counterposes to the ‘pathological’ interpretation of the petite bourgeoisie an alternative profile, one that stresses its confidence, its stability of allegiance and its commitment to centrism.     

Bureaucratic politics and the translation of movement agendas

Research on social movement outcomes focuses on the publicly visible stages of government policymaking. It rarely opens the black box of government's translation of movement demands beyond the agenda‐setting stage and before their materialization into legislative bills. Using a bureaucratic politics perspective, we suggest that bureaucrats play a central role in translating movement agendas into concrete problems and policy solutions, which they tend to link with their bureaus' missions and existing programs. We further suggest that relative consensus among bureaucrats when coupled with politicians' disinclination to intervene in the translation process tends to advantage conservative interpretations of movement agendas. Conversely, interbureau confrontation and political intervention are associated with more radical policy responses. Empirically, we examine the responses of the Israeli government to the large‐scale mobilization, in 2011, surrounding the rising costs of housing and living. We build on archival research and interviews with senior bureaucrats located in 11 central‐government ministries.     

Securing cyberspace: How states design governance arrangements

The functioning of modern societies increasingly depends on secure cyberspace. Given states' lacking capacities to protect this novel domain, governments draw on a variety of third parties for support. Yet, they face a challenge. While imposed control may limit third parties' competence, the abandonment of hierarchical control contradicts the widespread notion of national security. How do states navigate between these functional and national security imperatives to design governance arrangements? We develop a typology that combines cybersecurity problems (risks vs. threats) with governance modes (delegation vs. orchestration). This helps us to explore more than 100 cybersecurity policies across 15 different states. We find one predominant pattern. Governments delegate authority but maintain elements of hierarchical control, when they respond to threatening attacks. In contrast, governments orchestrate intermediaries by soft inducements to address risks and diffuse vulnerabilities in cyberspace. This contributes to both indirect governance scholarship and the debate on cybersecurity.     

Regional variations in public opinion on the affordable care act

One year after passage, the Patient Protection and Affordable Care Act (ACA) remains a divisive topic. Most publicly released polls on the law have focused on the views of Americans as a whole. But with much of the responsibility of implementation lying with the states, this essay explores whether opinion differs geographically. The analysis finds that views on the health reform law do differ by region, and these differences are most likely driven by the political leanings of a given area. While opinion nationally differs by age and race, this pattern does not hold when looking by region. Areas that have a larger share of uninsured and are slated to receive greater federal funding under the ACA also do not differ in their opinions. These data suggest that regional variations in attitudes about the ACA are based less on the demographic structure of a region and more on the political ideologies of residents in a given region. As implementation of the law continues, this analysis shows that national opinion data mask important regional variations in views of the ACA.     

Development and validation of a liquid chromatography-tandem mass spectrometry assay for hair analysis of atomoxetine and its metabolites: Application in clinical practice

Atomoxetine (ATX) is a potent inhibitor of the noradrenaline reuptake transporter approved since 2002 for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults as alternative treatment to methylphenidate. A procedure based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the determination of ATX and its main metabolites (4-hydroxyatomoxetine - 4 hydroxyATX - and N-desmethylatomoxetine - des-methylATX) in hair of one treated child and five treated adolescents. Since hair samples can be easily collected without the need for specials skills and exposing a patient to discomfort, hair testing of ATX and eventually of its metabolites should be useful, especially in case of pediatric patients, to check compliance in a wider time-window. After addition of duloxetine as internal standard, hair samples were overnight digested with 2ml 1M NaOH at 45°C. Then, analytes were extracted from alkaline solution with two different 2ml aliquots of tert-butyl methyl ether. Chromatographic separation was achieved at ambient temperature using a reverse-phase column and a mobile phase of 40% of water-60% 5mM ammonium acetate, 50mM formic acid, 4mM trifluoroacetic acid in acetonitrile-water (85:15, v/v). The mass spectrometer was operated in positive ion mode using multiple reaction monitoring. The method was linear over the concentration range 0.2-50ng/mg hair for the all analytes under investigation, with an intra- and inter-assay imprecision and inaccuracy always less than 20% and an analytical recovery between 33.1% and 76.1%, depending on the considered analyte. Only ATX and 4-hydroxyATX were detected in hair samples with concentrations varying from 0.2 to 2.0ng/mg hair and from 0.3 to 1.0ng/mg, respectively. Notwithstanding the absence of any dose-hair concentration relationship, hair monitoring of ATX and concomitant medications commonly administrated in ADHD children and adolescents can be crucial in verifying long-term compliance to prescribed medication in individuals displaying a non negligible tendency to refuse drugs and to lie on the adherence to therapy as a specific symptom of the disease.