Vaccine trial results generate debate and calls for further research

The first large-scale human trial of an HIV vaccine produces disappointing results overall, but finds that the vaccine may have been effective among some of the minority populations participating in the trial. Whatever the significance of this finding (the debate continues), there was a consensus: (a) that the trial provided very useful information on how to conduct large-scale HIV vaccine trials; (b) that further research needs to be conducted; (c) that governments need to contribute more to vaccine research and development; and (d) that existing prevention efforts must be maintained or expanded.     

Home care and prescription drugs to be funded under medicare

Canada's first ministers have signed a health accord that could potentially lead to significant changes to Canada's health-care system. But the agreement is short on details and the new initiatives may not keep pace with the expectations of Canadians.     

Adolescent self-poisoning: a cohort study of subsequent suicide and premature deaths

Previous self-harm has been identified as a risk factor for subsequent suicide by adolescents. The objective of the study was to identify further risk factors for subsequent premature death and suicide in a population of adolescents presenting with self-poisoning. A longitudinal cohort design using data-linkage of consecutive adolescent patients presenting to the Hunter Area Toxicology Service, a regional toxicology service for Newcastle, Australia, with the National Death Index of the Australian Institute of Health and Welfare was used. A total of 441 adolescents aged 10 to 19 years presented with self-poisoning over 5 years from January 1991 to December 1995, with follow-up to March 2001. There were 14 deaths total, eight of which were likely suicides. There was a 22-fold increase in suicide rate for males and a 14-fold increase for females compared with age-normalized population rates. Adjusted hazard ratios (95% CI) forpremature death were male gender 3.77 (1.11-12.78), nonaffective psychotic disorders 16.3 (3.83-69.34) and the mental illnesses of childhood 6.12 (1.68-22.23). There was a similar pattern for suicide: Male gender, nonaffective psychotic disorders, and the mental illnesses of childhood confer greater risk for subsequent suicide or premature death in this population.