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Interaction of butorphanol, with monoamine oxidase inhibitor, tranylcypromine.

This investigation examines the possibility of interaction between tranylcypromine and butorphanol in comparison to pethidine. The LD50 of pethidine and butorphanol were determined in mice pretreated with the non-selective monoamine oxidase (MAO) inhibitor, tranylcypromine orally for 8 days or with oral saline solution. Tranylcypromine decreased the LD50 of both pethidine and butorphanol by 78% and 41%, respectively. Anesthetized rabbits with halothane pretreated with tranylcypromine or saline were given pethidine (5 mg/kg i.v.) or butorphanol (0.5, 1 and 2 mg/kg i.v.). Pethidine produced a marked increase in blood pressure in rabbits pretreated with tranylcypromine and did not affect significantly the heart rate. Butorphanol did not affect either blood pressure or heart rate at doses of 0.5 or 1 mg/kg. However, the largest dose of butorphanol (2 mg/kg) produced hypotension and tachycardia in rabbits pretreated with tranylcypromine. Neither pethidine nor butorphanol affected the temperature of anesthetized rabbits pretreated with tranylcypromine or saline.     

Joint custody: a comprehensive review

This article presents a comprehensive overview of joint custody. The history and legislative implications are discussed, as are pertinent issues relative to the reported advantages and disadvantages of joint custody. Finally, the role of the mental health professional in assisting with counseling divorced families either before, during, or after a custody decision is discussed.     

A comparison of methods used in the UK and Ireland for the extraction and detection of semen on swabs and cloth samples

The recent formation of a United Kingdom and Irish working group, the Body Fluids Forum (BFF), highlighted the need to investigate different working practices prior to any inter-laboratory comparison work and identification of best practice. Various dilutions of semen were seeded onto swabs and cloth samples for each BFF member laboratory to test using their standard techniques. The results showed that the detection of acid phosphatase on swabs is best achieved using direct testing rather than on an extract from the swab. Extraction methods for spermatozoa require a balance to be achieved between using a sufficient volume of water to ensure optimal release and minimal volume to ensure a concentrated extract. PSA tests were investigated and found to be more sensitive than Choline. DNA profiles were obtained from samples in which no spermatozoa had been detected during microscopic examination.     

Institutionalizing ambiguity: the management review group and the reshaping of the defence policy process in Canada

Abstract: The Department of National Defence (dnd) and the Canadian Armed Forces (CF) have been the subject of many studies intended to elicit a better return from defence efforts. None of these studies have been at all comprehensive. The 1971 white paper, Defence in the 70s, introduced a new study aimed at “ensuring maximum effectiveness” in DND. The 1972 Management Review Group (MRC) report changed the entire administrative structure of DND and the CF, introduced new concepts for management, and shifted the power structure of the central bureaucracy. By the end of 1972, DND and the CF had a new set of principal actors, a new administrative structure, and a new policy process. To some the changes were more significant than previous unification reforms. The mrc report stands in sharp contrast to other studies because it has not been available to officials, scholars, or the public. Yet an awareness of die concepts that underlie the recommendations of the MRG is fundamental to understanding why the National Defence Headquarters exists and functions as it does today and why some issues are advanced over others. Sommaire: Le ministére de la Défense nationale (MDN) et les Forces armées cana-diennes (FC) ont fait l'objet de nombreuses “études” visant à accroître le rendement des efforts faits dans le domaine de la défense. Aucune de ces études n'est exhaustive. Le livre blanc de 1971, s'intitulant La défense dans les années 70, présentait une nouvelle étude dont l'objectif était “d'assurer une efficacité maximale” au sein du MDN. Le rapport de 1972 du Management Review Group (MRG) a modifyé toute la structure administrative du MDN et des FC, a introduit de nouveaux concepts de gestion et a entraîné un déplacement des pouvoirs de la bureaucratie centrale. Vers la fin de 1972, le MDN et les FC étaient dotés de nouveaux acteurs principaux, d'une nouvelle structure administrative et de nouvelles méthodes d'établissement de politique. Pour certains, ces changements ont été plus importants que les précédentes réformes d'unification. Contrairement aux autres études, le rapport du MRG n'a pas été mis à la disposition des responsables, des intellectuels ou du public. II est pourtant essentiel de con-naître les concepts sur lesquels s'appuient les recommandations du MRG si Ton veut comprendre pourquoi le Quartier général de la Défense nationale est ce qu'il est aujourd'hui, son mode de fonctionnement et les raisons pour lesquelles certaines questions ont pris le pas sur d'autres.