Preparation of degraded human DNA under controlled conditions

DNA typing through analysis of short tandem repeats (STRs) and mitochondrial DNA (mtDNA) by means of the polymerase chain reaction (PCR) and sequencing are the common methods for the forensic identification of persons and reconstruction of kinship, especially when skeletal human remains have to be analyzed. Furthermore, samples typically found at crime scenes may be both quantitatively and qualitatively inadequate since they may contain very scarce and often degraded DNA due to exposure to heat, light, humidity, and microorganisms. In order to improve the performance of STR typing technology in those cases where DNA availability is limited, it would be desirable to have a source of degraded DNA with known properties. For this purpose, we have developed a method to prepare artificially degraded DNA under controlled conditions. By treatment of genomic DNA with sonication and DNAse I we have produced DNA fragments within a defined range of lengths. STR typing of this degraded DNA with a commercially available multiplex kit could only produce partial profiles as indicated by the absence of STR alleles with sizes >200 bp. This artificially degraded DNA can be used for the improvement and standardization of STR typing protocols when only highly degraded DNA is available for analysis.     

Integrating Critical Race Theory and Postmodernism Implications of Race, Class, and Gender

This paper begins with an overview of criticalrace theory tenets, which in turn will befollowed by an overview of postmodernism. These bodies of knowledge consist of an arrayof ideologies; but for the purpose of thisarticle only the fundamentals of each will bediscussed. Thereafter, an integration ofthese two contemporary areas of thought willdemonstrate the constructive linkage ofcritical race theory and postmodern theory. Theintegrations that follow will emphasize how acollaboration of critical race theory tenetsand postmodern thought can contribute to asuccessful, and more importantly improved,analysis of the social constructions of race,class, and gender. In addition, theintersectional analysis presented willdemonstrate a more informative and betterunderstanding of the subtleties of blatant andmore hidden forms of race, class, and gender.     

Die Prognosegüte von Wahlbörsen und Meinungsumfragen zur Bundestagswahl 2005

In the aftermath of an election it has become customary to systematically compare the predictive accuracy of polls and political stock exchanges. However, most of these analyses do not emerge from real predictions. In this research note, we compare the predictive performance of a time-series model to the accuracy of polls and a political stock market in the 2005 german Bundestag (general) election. Our analysis shows that Wahl$treet, the most significant german political stock exchange, was again closest to the actual results leaving commercial polling institutes behind. Due to the exceptionally large errors of most institutes we briefly discuss how such inaccurate forecasts might affect voting behaviour in the light of social choice theory.     

Global Governance through Private Organizations

Governance at international and global levels is not only provided through states and markets but also through a variety of private organizations. The business world is well represented through this kind of organization and contributes to global governance through self-regulation across a number of industries. This article examines these efforts in the encompassing organization of global commerce, in the pharmaceutical industry and among dye stuffs producers. Smaller organizations are generally better suited to monitor compliance and impose sanctions on members violating the codes and norms behind self-regulation. Even small organizations, however, are confronted with problems and there is also evidence of large and very complex organizations having established effective mechanisms as alternatives to public regulation. These experiences can be built into theories on self-regulation as a form of global governance.     

Lender Liability for Environmental Harm: An Argument Against Negligence Based Rules

A firm strictly liable for any harm done will choose an inefficiently low care level if there is a possibility that it goes bankrupt. One possibility to improve care is extending liability to secured lenders, as applied under CERCLA and as currently being discussed in the EU. I compare strict liability, partial liability and vague negligence for lenders in a model with moral hazard and environmental auditing. While auditing is socially valuable only if it increases the firm's care level, the creditor also calculates the reduction in the information rent. Thus, for each possible care level, monitoring is always too high. This effect is aggravated by a vague negligence rule, where the probability that a lender is found liable decreases in the level of auditing. It is demonstrated that partial liability is superior, because the incentive for excessive monitoring is diminished.     

Fragmentation and the growth of local government

An assumption of the post-World War II metropolitan reform movement was that fragmentation of metropolitan regions into multiple local governments was wasteful and inefficient, increasing the cost and size of government. More recently, ‘polycentrists’ have argued that the competition between multiple governments in metropolitan regions can in factreduce the growth in government by providing a competitive check on the excessive demands of local bureaucrats for more resources. In this article, I explore the effects of fragmentation on growth in the size of suburban municipal government budgets and in the number of services offered. Competition inherent in more fragmented metropolitan regions is shown to slow the expansion in local government expenditures and service levels.     

A. Reviews: general

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THE ORIGINS OF ARAB NATIONALISM. Edited by RASHID KHALIDI, LISA ANDERSON, MUHAMMAD MUSLIH, and REEVA S. SIMON. 288 pp. + glossary, bibliography, index. New York, Columbia University Press, 1991.

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