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Managing incidental findings in human subjects research: analysis and recommendations. 总被引:8,自引:8,他引:0
Susan M Wolf Frances P Lawrenz Charles A Nelson Jeffrey P Kahn Mildred K Cho Ellen Wright Clayton Joel G Fletcher Michael K Georgieff Dale Hammerschmidt Kathy Hudson Judy Illes Vivek Kapur Moira A Keane Barbara A Koenig Bonnie S Leroy Elizabeth G McFarland Jordan Paradise Lisa S Parker Sharon F Terry Brian Van Ness Benjamin S Wilfond 《The Journal of law, medicine & ethics》2008,36(2):219-48, 211
No consensus yet exists on how to handle incidental findings (IFs) in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are findings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. 相似文献
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During the 1960s, the US government entered into an agreementwith the UK government to construct a military facility in theChagos Archipelago. The UK government excised the Archipelagofrom the colony of Mauritius and created the British IndianOcean Territory (BIOT). Diego Garcia was transferred to theUnited States and the indigenous people of the entire Archipelagowere secretly banished. This process led to their chronic impoverishment.In the Bancoult cases, the English courts held the exile tobe unlawful and that the Chagossian people possess a publiclaw right of abode in the Chagos Islands. This article examineswhether international law can facilitate the resettlement tothe Chagos Islands via recognition of BIOT's non-self-governingstatus. It also explores the prospect of securing compensationfor the loss of ancestral lands by reference to existing andevolving international standards on indigenous rights. 相似文献
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The principal aim of our study is to contribute to the debate over whether regulation is enacted in the interest of consumers, producers, political agents, or some combination of these. We examine the legislative debates and subsequent regulatory bills surrounding road transportation regulation in Ireland in light of the three dominant theories which purport to explain the existence of regulation: the public interest theory and the so-called Chicago and Virginia theories. A unique feature of our study is an attempt to integrate specific rhetorical concepts used in the public policy debates into the theoretical analysis of regulation. One noteworthy conclusion of our study is that theories of economic processes affect the shaping and results of public policy. 相似文献
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Allen H. Barton 《Scandinavian political studies》1998,21(1):71-85
In 1948–49 the Sociology Office of the University of Oslo, under the guidance of Prof. Paul Lazarsfeld of Columbia University, initiated a series of studies on the Norwegian economic planning system. Part of this Planning Project was a national election survey in the fall of 1949, on a modified probability sample of 2600 people. The results show the paramount influence of economic class on voting, interpreting class as a combination of employer/employee relationship, property ownership, prestige-status, and income. Indicators of the homogeneity of class environment also played a role. Given the occupational structure of Norway, the Labor party had to win over part of the non-working-class population to obtain control of the government. They did this by winning about 1/3 of the white-collar vote, and about 1/4 of the farmers and fishermen. The policies of economic stabilization - control of inflation through price controls, wage controls, food subsidies, and rationing, and maintenance of full employment under conditions of "suppressed inflation" - were crucial to winning over these white-collar and farm voters. 相似文献