An immunohistochemical study of basic fibroblast growth factor in early acute myocardial ischemia

With the use of immunohistochemistry, the expression of basic fibroblast growth factor (bFGF) in early acute myocardial ischemia of rats was studied. It was observed that there was an initial (30 min) rise in bFGF expression in limited ischemic myocardium areas and perimyocardial ischemia areas. The grade of expression of bFGF increased with the continuation of ischemia. The results of image analysis and statistical process suggested that the expression of bFGF reach a high level in ischemic myocardial areas after three hour's of ischemia, significantly higher than in control group and in group B1, but no significant difference in pericardial ischemia areas and normal areas of the same group. In summary, early acute myocardial ischemia is accompanied by rapid and prolonged increase in expression of bFGF with characteristic spatial and temporal kinetic. This finding suggests that the immunohistochemical staining of bFGF provide objective morphologic evidence for the diagnosis of early myocardial ischemia.     

The use of serum protein analysis in the diagnosis of fatal envenomation via Crotalus horridus (timber rattlesnake)

Deaths occurring due to rattlesnake envenomization are extremely rare and must be thoroughly investigated in the same manner as any other type of death. Our research presents the case of an adult white male who suffered a fatal timber rattlesnake (Crotalus horridus) envenomation in northwest Florida in 2018. Blood samples were taken from the decedent's heart and vasculature of the chest and sent for serum proteomic analysis. Serum proteomic analysis was utilized in order to identify proteins from timber rattlesnake (C. horridus) found within the victim's blood. The confirmation of the presence of timber rattlesnake venom within the victim's blood allows the forensic pathologist to determine the cause of death most accurately and likewise, assists with the manner of death determination. Blood samples were separated into two groups: one with the abundant endogenous proteins depleted to facilitate detection of lower abundant proteins and one undepleted. In the depleted sample, a total of 712 proteins were identified, with 47 of the proteins (6.6%) occurring originating from timber rattlesnake (C. horridus). Likewise, a total of 742 proteins were identified in the undepleted sample, with 52 of the proteins (7.0%) occurring in timber rattlesnake (C. horridus). No timber rattlesnake (C. horridus) proteins were found in control human serum.     

Countervisions of Modernity: David Roberts,The Total Work of Art in European Modernism

David Roberts's The Total Work of Art in European Modernism extends and deepens the analysis of the counter-paradigm of redemptively inspired art to modernism's own pre-occupation with secularization. It addresses the imbalance in social and critical theory whereby progressive secular rationalization has been elevated to the sole logic of modernity, and the romantic redemptive tradition has been reduced to a marginal counter-enlightenment. The total work of art paradigm allows Roberts to demonstrate how the programme of modernity has been constituted by internal tensions and antinomies from the very beginning.     

“We want financial accountability”: deconstructing tensions of community participation in CHPS,Ghana

This article reports on the ways and factors that facilitate or constrain community participation in the Community-based Health Planning and Services (CHPS) programme in Nsanfo, a village in Central Region of Ghana. We found that the community made an important step through mobilising the necessary resources in establishing the CHPS compound, which has resulted in improved access to health care. Yet maintaining the facility did not matter most to community members, owing chiefly to unmet demands for financial accountability pertaining to the running of the programme. Failure to clearly identify various actors and their roles potentially explains this state of affairs.     

Why the “Sacred” Is a Better Resource Than “Religion” for Understanding Terrorism

The popular media and many in academia often overstate the role that religion, and its supposedly unique qualities, has played in recent acts of terror. In this article, I argue that the notion of religious violence is unhelpful and that there is a more useful concept that we can utilize to draw out the values and ideas that play a role in the move to violence in both religious and secular groups. From a series of case studies on religious and non-religious groups, I have drawn out an alternative framework for investigating and learning from the role that beliefs play in motivations and justifications for terrorism. This framework uses the concept of non-negotiable (or “sacred”) beliefs. It is as applicable to secular as it is to religious groups, and can show us much more about how such beliefs can contribute to violence.     

Students and the police in Ghana: mixed feelings

This study examines university students’ perceptions of the Ghana police service in contrast with general population studies that explain citizens’ attitudes toward the police. Two research questions guided this study: (1) What are university students’ perceptions of the police? and (2) What factors influence university students’ perceptions of the police? Using data collected from one large university in Ghana between the months of December 2012 and February 2013, the study found several intriguing findings. First, students have moderate trust in the Ghana police. Second, students critically evaluated police procedural fairness and effectiveness. Multivariate regression models revealed that vicarious experiences of police corruption, marital status, level of education, and ethnicity predicted students’ trust in the police as well as influenced their perceptions of fairness and effectiveness. Policy implications of the findings are discussed.     

Principal-Agency Theory in Illegal Markets: Cooperation and Conflict Among Chinese Loansharks

There are management and organizational problems common to both legal and illegal businesses, such as moving one party to act in the interest of another rather than his own. In principal-agency theory, the party that wants someone else to do a job on his behalf is called the “principal” and the other party is called the “agent”. Principal-agency theory tries to find solutions to real and potential conflicts that arise from such transactional arrangements. We believe principal-agency theory has great potentials for understanding the operation and interpersonal relationships of criminal enterprises, in addition to the structural arrangements (e.g., a disorganized crime market) and the social network perspectives. Using a case study of Chinese loan sharking and cannabis cultivation in the Netherlands, we seek to make a theoretical contribution to existing literature on organized crime by focusing on how different individuals within a criminal enterprise negotiate the most efficient transactional arrangement in a principal-agent relationship amidst the uncertainties of an illicit market environment. We specifically look at four phases of the criminal enterprise studied: the selection of agents by the principal, attempts to bind these agents to the principal, potential conflicts and finally the solution of any problems. Incidentally, our study also gives insight in the less well-researched topic of loansharking.     

Competing Risks, Persistence, and Desistance in Analyzing Recidivism

A statistical procedure is developed to analyze recidivism in samples whichare subject to the presence of desisters and to multiple modes ofreconviction. This allows for a more accurate study of individuals'transition and hazard in the type and timing of offenses following aspecific type of conviction. The use of a nonparametric approach forinvestigating failure in the presence of other acting causes is shown;initial estimators of the probabilities of reconviction for different typesof offenses are obtained, and the method can be used both to display thedata and to choose an appropriate parametric family for the survivaltimes. An exponential mixture model for competing risks is presented insuch a way that it allows us to adjust for concomitant variables and toassess their effects on the probabilities both of reconviction forpredetermined types of offenses and desistance and of the hazards ofreconviction; a method for assessing calibration of predicted survivalprobabilities is suggested. A 21-year follow-up of persons convicted ofindecent assault on a female in 1973 illustrates the methods; we find ahigh probability of sexual reconviction for individuals with previoussexual convictions and evidence of diversity and a raised hazard ofreconviction for young chronic offenders.