Variability of cannabinoid findings in blood

Cannabis products have been administered for many centuries; today, cannabis is the most widely used illegal drug all over the world. Nevertheless, the interpretation of cannabis findings in blood with regard to consumption behaviour and/or estimating the elapsed time since the last cannabis use is still a very challenging task. A wide variation of pharmacokinetic parameters has been observed even in experimental studies. Different chemical structures of precursors, smoking dynamics, pyrolysis of phytocannabinoids and frequency of drug use affect the amount of THC absorbed. Polymorphic enzymes are involved in phase-I-metabolism of THC. Pharmacological effects of other cannabinoids or medication on the pharmacokinetics of THC have not yet been studied in detail. Hydrolysis of cannabis conjugates may occur during storage of blood samples and processing of specimens for analysis; knowledge on the stability of cannabinoids in forensic specimens is still poor. Whether determination of cannabinoid conjugates may be useful is a matter of further consideration. At present, the broad variation of pharmacokinetic parameters and the limiting factors discussed in the present paper should be taken into account when using data from experimental studies for interpretation of analytical results in forensic case work.     

The role of industrial Advisory Boards in technology transfer between universities and industry

This paper suggests that industrial Advisory Boards (IAB) have a significant, yet sometimes underestimated role in the transfer of technology between universities and industry, in the context of university-industry collaborative arrangements. Some barriers to technology transfer are described, and the role of the IABs in overcoming them is discussed, as a valuable forum for dynamic interaction between researchers, thus acting as a facilitator in the process of technology transfer.     

Determination of blood/serum ratios of different forensically relevant analytes in authentic samples

For forensic toxicological investigations only whole blood, but no serum is often available. Pharmacokinetic data are helpful for interpreting the results, but most of these studies indicate serum or plasma concentrations. In order to obtain reliable conversion factors which also take intersubject variability into account, the blood/serum ratios (B/S) of oxycodone, morphine, fentanyl, hydromorphone, zopiclone, MDMA, dexamphetamine, alprazolam, risperidone and 9-hydroxyrisperidone were determined by LC-MS/MS using authentic samples. Blood and corresponding serum samples were obtained from driving studies performed with controlled or known dosages of the above drugs. The analytes were analysed in blood and serum and the following mean B/S ratios (relative standard deviations) were determined: oxycodone 1.48 (8.19 %); morphine 1.03 (3.59 %); fentanyl 0.87 (13.9 %); hydromorphone 1.04 (8.11 %); zopiclone 0.89 (16.1 %); MDMA 1.19 (8.04 %); dexamphetamine 0.89 (10.9 %); alprazolam 0.81 (5.84 %); risperidone 0.65 (7.52 %); 9-hydroxyrisperidone 0.73 (12.3 %). These mean values are largely in line with those reported in the literature. The B/S ratios did not appear to depend on partition coefficients, whereas there was strong evidence that B/S ratios decreased with increasing plasma protein binding.     

Research potential and limitations of trace analyses of cremated remains

Human cremation is a common funeral practice all over the world and will presumably become an even more popular choice for interment in the future. Mainly for purposes of identification, there is presently a growing need to perform trace analyses such as DNA or stable isotope analyses on human remains after cremation in order to clarify pending questions in civil or criminal court cases. The aim of this study was to experimentally test the potential and limitations of DNA and stable isotope analyses when conducted on cremated remains.For this purpose, tibiae from modern cattle were experimentally cremated by incinerating the bones in increments of 100 °C until a maximum of 1000 °C was reached. In addition, cremated human remains were collected from a modern crematory. The samples were investigated to determine level of DNA preservation and stable isotope values (C and N in collagen, C and O in the structural carbonate, and Sr in apatite). Furthermore, we assessed the integrity of microstructural organization, appearance under UV-light, collagen content, as well as the mineral and crystalline organization. This was conducted in order to provide a general background with which to explain observed changes in the trace analyses data sets. The goal is to develop an efficacious screening method for determining at which degree of burning bone still retains its original biological signals. We found that stable isotope analysis of the tested light elements in bone is only possible up to a heat exposure of 300 °C while the isotopic signal from strontium remains unaltered even in bones exposed to very high temperatures. DNA-analyses seem theoretically possible up to a heat exposure of 600 °C but can not be advised in every case because of the increased risk of contamination. While the macroscopic colour and UV-fluorescence of cremated bone give hints to temperature exposure of the bone's outer surface, its histological appearance can be used as a reliable indicator for the assessment of the overall degree of burning.     

Take the car keys away: Metropolitan structure and the long road to delinquency

Purpose

This research fulfills a void in offender mobility discourse. Metropolitan socioeconomic and spatial structure, defined in crime pattern theory as the urban backcloth, plays a significant role in shaping travel behavior; and yet, current analysis of offender mobility continues to favor individual characteristics to account for travel range.

Methods

Using a large sample of juveniles, both delinquent and at-risk youth (N = 2,552), this study compared the predictive utility of individual characteristics against indicators of urban backcloth.

Results

Delinquent youth were found to be more sensitive to the environmental conditions exerted by community-level socioeconomic characteristics than their at-risk counterparts. However, two factors—intercity hierarchical structure and motor vehicle access—accounted for travel variability among all youth.

Conclusions

Offending behavior must be examined within the context of a dynamic environmental context formed by the metropolitan socioeconomic and spatial structure. Delinquents constitute an identifiable subgroup of youth.     

Weather-induced changes in cannabinoid content of hair

Authentic hair samples from Cannabis users and a drug free hair sample which was separately spiked with tetrahydrocannabinol (THC), cannabidiol (CBD) or cannabinol (CBN) were exposed outside as well as to natural sunlight at prevailing and elevated humidity in quartz glass tubes during 8 weeks. In addition, authentic and spiked hair samples were exposed to xenon arc radiation in a light exposure cabinet for 24 hours. Stability of THC, CBD and CBN in authentic samples differed from that of the spiked hair. The radiation experiment revealed that CBN could not be measured in hair which had been spiked with THC. Under all conditions chosen the concentrations of THC, CBD and CBN decreased. At high humidity the concentrations declined more rapidly. In both authentic and spiked samples THC was most unstable compared to CBD and CBN. Therefore, in hair analysis determination of CBD and CBN seems promising to detect Cannabis exposure even under unfavorable conditions.     

Which Public Goods are Endangered?: How Evolving Communication Technologies Affect The Logic of Collective Action

Public Choice - The theory in Mancur Olson's The Logicof Collective Action is built fromhistorically uncontroversial assumptionsabout interpersonal communication. Today,evolving technologies...     

Using friends for money: the positional importance of money-launderers in organized crime

Despite the significant amount of attention and resources invested into the global anti-money laundering (AML) regime, there is a dearth of empirical studies on the role of money-launderers in illicit markets. This research tests two primary justifications of AML policy: 1) most money-launderers would not be detected through criminal investigations of predicate crimes and organized crime groups; and, 2) professional money-launderers play an important role in illicit markets and criminal networks. We extracted information about money-launderers in the drug market from police intelligence reports over a three-year period. Social network analysis was used to assess the positional importance of the launderers. The results show that most individuals are self-laundering, and relative to other market roles, launderers are not particularly central players. Policy implications for AML enforcement are discussed.