Histological correlates of post mortem mitochondrial DNA damage in degraded hair

We have assessed the histological preservation of naturally degraded human hair shafts, and then assayed each for levels of amplifiable mitochondrial DNA and damage-associated DNA miscoding lesions. The results indicate that as sample histology is altered (i.e. as hairs degrade) levels of amplifiable mitochondrial DNA decrease, but no correlation is seen between histology and absolute levels of mitochondrial DNA miscoding lesions. Nevertheless, amplifiable mitochondrial DNA could be recovered across the complete range of the histological preservation spectrum. However, when template copy number is taken into consideration, a correlation of miscoding lesions with histology is again apparent. These relationships indicate that a potential route for the generation of misleading mitochondrial sequence data exists in samples of poor histology. Therefore, we argue that in the absence of molecular cloning, the histological screening of hair may be necessary in order to confirm the reliability of mitochondrial DNA sequences amplified from hair, and thus represents a useful tool in forensic mitochondrial DNA analyses.     

The Non-Resident Parental Role for Separated Fathers: A Review

Ideas about the role of fathers in the separated family havechanged over the last few decades. The prevalent legal constructof ‘co-parenting’ implies that children should beable to maintain contact with a non-resident parent, usuallythe father, if they wish, except in cases where there has beenabuse or violence. Research in several disciplines has soughtto explain the processes of contact by examining the behaviourof separated fathers, their relationships within the family,and the separated family as a whole. Quantitative studies haveexplored levels of involvement, the father–child relationshipand the inter-parental relationship as factors affecting children’soutcomes, while an expanding body of qualitative work has soughtto map the practice of co-parenting through identifying thediversity of separated parenthood and the perspectives of non-residentfathers in particular. The contributions of these diverse approachesto current debates on non-resident fathers are reviewed in thisarticle.     

Problems with the regulation of assisted reproductive technology: a clinician's perspective

The use of the Infertility Treatment Act 1995 (Vic) as a model for regulating reproductive technologies throughout Australia poses many problems. This article argues that the legislation in Victoria is overly restrictive. In particular, banning embryo research is hypocritical. Embryo research was required to develop the clinical procedures and should be used to test innovations. Other problems are restricted access; privacy infringement; an intrusive regulatory body; conflicts with other laws; and confusion because of poor drafting or lack of foresight. Uniform statutes are unnecessary. The interests of individuals and the community are better served by regulation through the Reproductive Technology Accreditation Committee.     

Is crime a man's world? Issues in the exploration of criminality

Although the role of the woman offender in the scientific study of criminality has traditionally been largely unexplored, recent studies indicate both an increase in reported female crime and an upsurge in interest on the subject. The general state of the literature is examined and suggestions for the improvement of research in the area are offered.     

Minocycline-related black thyroid

Black pigmentation of the thyroid gland has been observed in patients chronically taking minocycline antibiotics. Pigment changes of the skin, blood vessels, and bone have also been reported. Some of these changes may be caused by traumatic or toxic etiologies, therefore persons conducting forensic death investigations need be aware of minocycline-related changes. This article reviews pigment changes of the thyroid gland and discusses the potential forensic import of such findings.