Fatal intraoperative hemorrhage during spinal fusion surgery for osteogenesis imperfecta

Osteogenesis imperfecta (OI) is an uncommon inherited systemic disorder of the connective tissues characterized primarily by varying degrees of bony fragility. Consequently, individuals affected by this condition frequently suffer severe skeletal injuries from otherwise innocuous traumatic events. This syndrome has other associated abnormalities, including hydrocephalus and brain stem compression on the basis of cranial developmental defects (platybasia), cardiac and vascular problems, respiratory disease from spinal deformities, vascular fragility, a bleeding disorder caused by an apparent platelet function abnormality, and anesthesia-related hyperpyrexia. A case is presented here of a young girl with advanced OI in whom intraoperative death occurred as a consequence of inadvertent rib fractures, with subsequent uncontrollable hemorrhage. OI may also potentially be mistaken for child abuse by an inexperienced examiner.     

A fatal case of oral ingestion of toluene

A 51-year-old male ingested orally a large quantity of toluene and died about 30 min later. The presence of toluene in body fluids and tissues was confirmed by gas chromatography and gas chromatography/mass spectrometry. Tissue distribution of toluene showed that the liver detected the highest content of toluene (433.5 micrograms/g), except for the stomach contents, followed by pancreas (88.2 micrograms/g), brain (85.3 micrograms/g), heart (62.6 micrograms/g), blood (27.6 micrograms/g), fat (12.2 micrograms/g) and finally cerebrospinal fluid (11.1 micrograms/g).     

Extraction of diquat with 1-butanol from biological materials

Diquat can be extracted with 1-butanol from high pH solution in the presence of several moderate reductants. The red colored reduced compound of diquat in water turns to a purple compound in 1-butanol. The absorption of the purple compound is 0.105 at 383 nm and 0.119 at 520 nm in 1 microgram diquat/ml 1-butanol. The latter value is a little higher than that of the red compound at 495 nm in water. The purple compound is much more stable than the red compound in water. More than 80% of 10 ppm diquat added can be extracted from serum, blood, tissues, urine and some drinks. The extraction with 1-butanol is useful for concentration of diquat contained in large volume. The lower limit of detection is 0.1 microgram/ml 1-butanol. Paraquat is insoluble in 1-butanol under the same condition. Therefore, this method is applicable for the determination of diquat when paraquat is also contained in the solution.     

Green pigments in epidermal blisters of decomposed cadavers

A spectrophotometrical method for discrimination between sulfhemoglobin (SHb) and choleglobin was applied to analyses of the green pigments in epidermal blisters of decomposed cadavers. SHb appeared to be a predominant constituent of the pigments, although significant amounts of choleglobin, one third to one sixth of SHb, were also demonstrated. The present results indicate that the greenish discoloration of decomposed cadavers is due to formation of a mixture of SHb, choleglobin and possibly other denatured hemoglobin derivatives.     

FEDERALISM IS ALIVE AND SURPRISINGLY HEALTHY

Reading the comparative analysis of federations as different, constitutionally and culturally, as Canada, the USA, Australia, India and Nigeria, to mention only a few, is to agree with the title of this review. The words are taken from the Introduction to Bakvis and Chandler and this review argues that use of the word "surprisingly" is misplaced. Much of the writing critical of federalism has been labouring under a misunderstanding of its dynamic nature and its underlying strengths.     

A conceptual framework for police functions and services

Police functions and services are currently based on three implicit basic conceptual units: the person, the process, and the product. Each one of these was the fundamental assumption for one of the three historical models of police science: the Personal Qualities Model, the Community Relations Model, and the Scientific Management Model. Although none of these models has ever been implemented in a pure form, modern police science is implicitly based on their three basic conceptual units which are applied to different but specific areas of police functions and services. However, these conceptual units have never been explicitly reconciled with each other, thus at times resulting in contradictory proposals. A comprehensive theory of police functions and services requires a conceptual framework for explicitly relating the person, the process, and the product. A two-dimensional framework is proposed based on a psychological and a sociological level of analysis.