Innovation capacity in the healthcare sector and historical anchors: examples from the UK,Switzerland and the US

Innovation is an integral part of economic development in developed economies. In the post 2008 period, a key policy agenda is that of sustainable development, which calls for innovation in all aspects of value-chains. In this paper, we focus on innovation from the biotech—pharma perspective to see whether or not this will lead to a sustainable future for the regions where there are clusters of firms in this sector. We examine data from a recently completed European Union study of innovation in the Healthcare sector from the UK and Switzerland, countries with an historical base in pharma, to understand how innovation pathways vary at the regional level in the broader life sciences, which incorporate biotech and more. Innovation in the healthcare sector in two regions, Oxfordshire in the UK and Zurich in Switzerland are compared. We contextualize our discussion by drawing on studies that focus on the sector in the US, specifically Boston. The analytical framework comprises three elements: innovation systems and national and regional economic development theories are the first two, followed by approaches which consider organizational or institutional activity. This framework is used to help explain and understand the complexity of how innovation is organized at the sub-national level. The overall context is that it is increasing becoming a condition for government financing of research that it has more immediate application in industry or have the possibility of commercialisation (e.g., translational research).     

Responding to the ISIS threat: extending coercive non-trial-based measures in the Counter-Terrorism and Security Act 2015

This article evaluates certain recent changes in counter-terror law and policy in response to rising threats to security in recent years, often associated with the activities of supporters of ISIS or similar groups, or suspected supporters. A range of security concerns and policy strands led to the introduction of a number of new counter-terror measures in the Counter-Terrorism and Security Act 2015. This article does not set out to provide a comprehensive examination of the Act's provisions, but covers its extension of coercive non-trial-based measures aimed at terrorist suspects generally, but particularly at persons who have gone abroad to support ISIS or may seek to do so: the introduction of Temporary Exclusion Orders, excluding persons suspected of travelling to Syria to fight with ISIS from the UK temporarily, travel restrictions, and the strengthening of TPIMs (a form of ‘light touch’ control order). This article considers, in the aftermath of the November 2015 Paris massacre, the roles to be played by the new and planned measures in terms of increasing security, and the extent to which their design has also been influenced by the ECHR, taking account of relevant jurisprudence under the Human Rights Act and at Strasbourg.     

The uneven playing field of school choice: Evidence from new zealand

New Zealand's 10‐year experience with self‐governing schools operating in a competitive environment provides new insights into school choice initiatives now being hotly debated in the United States with limited evidence. This article examines how New Zealand's system of parental choice of schools played out in that country's three major urban areas with particular emphasis on the sorting of students by ethnic and socioeconomic status. The analysis documents that schools with large initial proportions of minorities (Maori and Pacific Island students in the New Zealand context) were at a clear disadvantage in the educational market place relative to other schools and that the effect was to generate a system in which gaps between the “successful” and the “unsuccessful” schools became wider. © 2001 by the Association for Public Policy Analysis and Management.     

N-cyanomethyl-N-methyl-1-(3',4'-methylenedioxyphenyl)-2-propylamine: an MDMA manufacturing by-product

This paper describes the structural elucidation of a compound produced during the synthesis of 3,4-methylenedioxymethylamphetamine (MDMA) via the reductive amination of 3,4-methylenedioxyphenyl-2-propanone (3,4-MDP-2-P) with methylamine and sodium cyanoborohydride. The compound was isolated from MDMA by column chromatography, proton and carbon nuclear magnetic resonance spectroscopy, LC/mass spectrometry, and total synthesis were used to identify the compound as N-cyanomethyl-N-methyl-1-(3',4'-methylenedioxyphenyl)-2-propylamine. This compound has been identified as a potential synthetic route marker for the reductive amination of 3,4-MDP-2-P with methylamine and sodium cyanoborohydride and as such it should prove valuable to forensic scientists engaged in profiling illicit drugs. Profiling MDMA can provide useful information to law enforcement agencies relating to synthetic route, precursor chemicals and reagents employed and may be used for comparative analyses of different drug seizures. This paper also describes the structural elucidation of the analogous methylamphetamine synthetic route marker compound, N-cyanomethyl-N-methyl-1-phenyl-2-propylamine, produced during the reductive amination of phenyl-2-propanone using methylamine and sodium cyanoborohydride.     

Functional mental capacity is not independent of the severity of psychosis

BACKGROUND: Function-specific mental capacities are the legal criteria for competence. These are regarded as superior to clinical assessments of mental state and general function. AIMS: To determine whether tests of fitness to plead and capacity to consent are independent of each other and independent of mental state and global function in psychosis. METHOD: The MacCAT-T and MacCAT-FP, PANSS and GAF were administered to 102 compulsorily detained forensic patients with psychosis. Criteria for incompetence were inability to express a preference concerning treatment, and independent rating as unfit to plead. RESULTS: MacCAT-T, MacCAT-FP totals and sub-scales correlated with each other and with PANSS and GAF. Those independently rated unfit to plead or who were incapable of making a treatment choice scored significantly worse on all rating scales. No test had satisfactory sensitivity or specificity. CONCLUSIONS: Legal definitions of mind and of functional capacity offer a basis for structured clinical judgement regarding decision-making capacity. However, function-specific measures of understanding, reasoning and appreciation generate much the same results as measures of mental state and global functioning.     

EU update

This is the latest edition of Baker & McKenzie's column on developments in EU law relating to IP, IT and telecommunications. This article summarises recent developments that are considered important for practitioners, students and academics in a wide range of information technology, e-commerce, telecommunications and intellectual property areas. It cannot be exhaustive but intends to address the important points. This is a hard copy reference guide, but links to outside websites are included where possible. No responsibility is assumed for the accuracy of information contained in these links.     

The prevalence of drugs and alcohol found in road traffic fatalities: A comparative study of victims

Researchers have studied the involvement of drugs and alcohol in fatal road traffic incidents, but with particular emphasis on the possible impairment of the driver. This paper describes a comparative study of drug and alcohol findings in various victim groups (drivers of cars, vans or lorries, car passengers, motorcyclists, motorcycle passengers, cyclists and pedestrians) between 2000 and 2006. Post-mortem blood and urine specimens submitted were analysed by immunoassay, GC–NPD, GC–FID, GC–MS and HPLC–DAD. The results of 1047 cases indicated 54% of all victims were positive for drugs and/or alcohol, with the highest percentage of positive findings occurring in pedestrians (63%). Males between the ages of 17–24 were most likely to be involved in a road traffic accident, whether being in control of a vehicle (driver) or involved indirectly (car passenger, pedestrian, motorcycle passenger). A wide range of drugs were detected (e.g. drugs of abuse, anti-convulsants, anti-histamines, anti-inflammatories, anti-psychotics, cardiac drugs and over-the-counter products), but alcohol and cannabinoids were the most frequent substances across the victim groups. When detected, alcohol was commonly above the legal driving limit in blood and urine (> 63% in those in control and > 60% not in control). Overall, the presence of drugs and/or alcohol was of similar frequency in those victims in control (55% of driver, 48% of motorcyclists, 33% of cyclists) and not in control of a vehicle (52% of car passengers, 63% of pedestrians). This degree of frequency strongly implicates the involvement of drugs and alcohol in road traffic incidents and infers an effect on driving ability and individual impairment.     

Foreigners Everywhere,Nationals Nowhere: Exclusion,Irregularity, and Invisibility of Stateless Bajau Laut in Eastern Sabah,Malaysia

ABSTRACT

This article explores impacts of national and regional policies upon the Bajau Laut, who occupy the maritime border region shared by Malaysia, the Philippines, and Indonesia. It considers how maritime movements, ethnogenesis, visions for economic development and commercial interaction have evolved in the region. These processes, combined with contemporary nationalism, border securitization, and conservation render such populations both prominent as a target of governmental action and invisible in terms of provision of social services and implementation of conservation initiatives. These facets complicate issues of political belonging within the state of Sabah, the nation-state of Malaysia, and the wider ASEAN region.     

“I have always been so afraid”: Fearsome Encounters in Unni Lindell’s Rødhette

Norwegian crime writer Unni Lindell’s novel Rødhette [Red Riding Hood] (Oslo: Aschehoug & Co, 2004/2010) is a narrative about a woman whose feeling of safety transforms into a fear of violation, and how her defence against this fear takes the form of systematic violence. The novel is a rewriting of the traditional tale of “Little Red Riding Hood” and is a comment on the patriarchal premises of the most widely known version of this folktale. In the article, I discuss the representation of the female murderer as being in the grip of an affective economy based on the fear of male violence, represented in the novel by the metaphor of the “wolf”, and how fear grows into a comprehensive, moral and pragmatic, murderous orientation towards the world after an experience of violence. Theoretically, I draw on affect theory and particularly Sara Ahmed’s ideas about the affective politics of fear (The cultural politics of emotion. Edinburgh: Edinburgh University Press, 2014) and how this fear turns into a significant qualifier in encounters with people who are experienced as strangers (Strange encounters: Embodied others in post-coloniality. London: Routledge, 2000). Fear is treated in Lindell’s novel as a psychological constriction and a tool for the construction of agency, through which the mechanisms of othering and violence are explored.     

Preface to Yoshimi Shun'ya's Voice Capitalism

Abstract

This article is a translation of the preface to Voice Capitalism by influential sociologist Yoshimi Shun'ya. The chapter ties together a wealth of discourse on the meaning of sound to society and to the individual, and its evolving role as a means of expression and connection to our environments. Yoshimi walks us through Nagai Kafū's reverence for tangible sound, R. Murray Schafer's schizophonic soundscapes, Marshal McLuhan's essays on the impact of the advent of sound recordings and electronic voices, Glenn Gould's theories on the blurring borders between musical performer and audience – amongst numerous other topics and writers.