Fatal intoxication involving 2-methyl AP-237

Novel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled “2MAP” and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was treated for a drug overdose 3 years prior to his death. With no diagnostic findings at autopsy, the case was submitted for toxicological analysis. An unknown substance was detected in peripheral blood and urine using gas chromatography with nitrogen phosphorous detection (GC-NPD). Further testing was conducted using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) which confirmed the presence of 2-methyl AP-237 and potential metabolites in blood and urine. Quantitation by GC-NPD revealed concentrations of 2-methyl AP-237 in blood and urine at 480 ng/mL and 4200 ng/mL, respectively. The toxicological analysis also identified and quantitated alprazolam in the blood at 55 ng/mL. Additionally, the metabolism of 2-methyl AP-237 was investigated and three hydroxylated metabolites were identified in peripheral blood and urine. Limited literature is available for the detection and quantitation of 2-methyl AP-237 in postmortem specimens. Given the toxicological findings with unremarkable autopsy findings, this case is an example of a fatal intoxication involving 2-methyl AP-237.     

Lessons in suffering: Greek tragedy’s teachings on disability through Sophocles’ Philoctetes

Political theory often sees disability through the negative language of abnormality and inability, which perceives disability as a deficiency that deviates from the able-bodied. However, critical disability studies strives to transform the disabling language of political theory into an enabling project that sees the ability, unique perspectives, capacities, and contributions of people with disabilities. Through Sophocles’ Philoctetes, this article examines the negative ways in which disability is conceptualized, socially constructed, and (dis)valued, as well as the possibilities for a positive and enabling theory of disability. The character of Philoctetes exposes the negative social construction of disability as well as the extraordinary ability of those who live with chronic impairments. The Philoctetes meditates on the status of the disabled who are unfairly isolated from human community and who are often unfairly seen in an instrumental fashion that fails to recognize their fundamental status as human beings who are capable, valuable, and essential for the success of human endeavors and community. For political theory, the Philoctetes demonstrates the ability in disability, and shines brightly on the essential contributions that people with disabilities make in our societies. Philoctetes shows that the lives of people who live daily with chronic impairments need not be seen as necessarily tragic. Instead, these modes of being speak to human diversity, ingenuity, and triumph.     

The Responsibility to Protect at Ten: Glass Half Empty or Half Full?

Abstract

Far from having faded away, ten years after its formal adoption, the responsibility to protect (R2P), is arguably more relevant than ever. In the current overall context of protection crises, heightened in severity by the emergence of violent extremists, R2P has changed the way in which the international community characterises situations that involve protection failures, and has raised expectations about what should occur when atrocity crimes have been committed or are imminent. UN member states now agree that prevention is at the core of R2P, that international action should employ the full range of diplomatic, political and humanitarian measures, and that military force should only be considered as a measure of last resort. While there is continued contestation about particular aspects of R2P – as there is over much older normative advancements, such as human rights – R2P has helped to forge political consensus and build new institutional capacity to prevent and respond to atrocity crimes.     

The Role of Interface Shape on the Impact Characteristics and Cranial Fracture Patterns Using the Immature Porcine Head Model, ,

The forensic literature suggests that when adolescents fall onto edged and pointed surfaces, depressed fractures can occur at low energy levels. This study documents impact biomechanics and fracture characteristics of infant porcine skulls dropped onto flat, curved, edged, and focal surfaces. Results showed that the energy needed for fracture initiation was nearly four times higher against a flat surface than against the other surfaces. While characteristic measures of fracture such as number and length of fractures did not vary with impact surface shape, the fracture patterns did depend on impact surface shape. While experimental impacts against the flat surface produced linear fractures initiating at sutural boundaries peripheral to the point of impact (POI), more focal impacts produced depressed fractures initiating at the POI. The study supported case‐based forensic literature suggesting cranial fracture patterns depend on impact surface shape and that fracture initiation energy is lower for more focal impacts.     

Understanding the Roles of Context,Frequency, and Quantity of Alcohol Consumption in Child Physical Abuse: Risks for Mothers and Fathers

Alcohol use is related to child physical abuse, although little is known about gender-specific risks factors. This study examines the relationships between alcohol outlets, context-specific drinking, dose–response drinking and child physical abuse for mothers and fathers. Telephone interviews were conducted with 1973 female and 1050 male respondents in 50 California cities. Weighted negative binomial models were used to calculate the frequency of physical abuse in the past year. Drinking more often at restaurants was related to higher frequency of physical abuse for fathers, while mothers who drank more frequently at bars and parties used physical abuse more often. There were no significant dose–response drinking relationships for fathers. Drinking higher amounts at bars, parties, and restaurants was associated with less frequent physical abuse for mothers. Our findings suggest that a focus on drinking contexts may reveal heightened risk for many mothers who do not consume large amounts of alcohol.     

Perceptions of Gender Bias in the Promotional Process of a Detention Staff

With growing numbers of female staff in correctional settings, issues relating to promotional fairness are certain to occur. Historically, female detention staff held perceptions of being discriminated against in the promotional process due to gender biases. However, there is almost no recent examination of these perceptions. The current study addresses this shortcoming in the literature by using a sample of 362 sworn detention deputies ranked Sergeant and below at a large southern-central United States jail. Contrary to the data from a generation ago, more male detention staff perceive gender biases in the promotional process than females, and report that promotional decisions are based on arbitrary and informal factors. Women are more likely to perceive promotions to be fair and based on merit. Results are discussed in relation to two theoretical perspectives: the importation-differential experiences model, and the work-role prisonization model.     

Dual-System Families: Cash Assistance Sequences of Households Involved With Child Welfare

Dual-system families, those involved with the child welfare system and receiving public cash assistance, may be more vulnerable than families connected to only one of the two systems. This study advances our understanding of the heterogeneous and dynamic cash-assistance histories of dual-system families in the post–welfare reform era. With merged administrative data from Washington over the period 1998–2009, we use cluster analysis to group month-to-month sequences of cash-assistance use among households over the 37-month period surrounding child removal. Close to two thirds of families who received any assistance either had a short spell with Temporary Assistance for Needy Families (TANF) or lost TANF. Smaller percentages had steady support. Families who lose assistance are less likely than average to reunify while those who connect to benefits are more likely, suggesting that coordination between systems may serve dual-system families well.