The red herring of adolescent mental health

An increase in adolescent distress and mental health symptoms has been clearly documented since the COVID-19 pandemic, as has increased exposure to adverse childhood experiences. Layer on top of these stressors being a youth of divorcing or separating high conflict families, and adolescent symptomatology can suddenly become a flashpoint for parental attention, division and conflict. Approaching cases using an ecological and family systems framework is necessary for accurate conceptualization and assessment of best interests in the context of child custody evaluations. Doing so ensures that adolescent mental health does not become a red herring in high conflict cases, leading to undue focus on the adolescent's mental health without considering other salient factors in the case, such as the broader parent conflict. Programs offered at the Center of Excellence for Children, Families & the Law at William James College designed to improve the lives of youth by addressing parental conflict are described.     

A case for integrated development: pathways to improve child well-being

Economic strengthening interventions may increase income, assets, and food security. Donors and implementers see the potential for improvements in child well-being. This article presents lessons learnt from the implementation of two economic strengthening interventions. It finds missed opportunities with regard to child nutrition, and recommends: (1) integrating economic strengthening interventions with complementary development activities; (2) deep formative assessment to inform programme design; and (3) the use of community-based feedback loops. Development practitioners, funders, policymakers, and researchers must take every opportunity to improve the lives of children as young as possible to build healthy families, communities, and nations.     

The POLST (Physician Orders for Life-Sustaining Treatment) paradigm to improve end-of-life care: potential state legal barriers to implementation.

The Physician Orders for Life-Sustaining Treatment (POLST) Paradigm is designed to improve end-of-life care by converting patients' treatment preferences into medical orders that are transferable throughout the health care system. It was initially developed in Oregon, but is now implemented in multiple states with many others considering its use. An observational study was conducted in order to identify potential legal barriers to the implementation of a POLST Paradigm. Information was obtained from experts at state emergency medical services and long-term care organizations/agencies in combination with a review of relevant state law.     

Association Between Mother and Adolescent Reports for Assessing Relations Between Parent–Adolescent Communication and Adolescent Adjustment

An important research finding is that parent–adolescent communication is related to adolescent adjustment. However, when using self-report measures with multiple reporters, adolescent and parent reports do not correlate highly, and within-rater reports correlate higher than cross-rater reports. This limits the utility of traditional methods of aggregation across raters. The present study used canonical correlation to examine if and how mother and adolescent reports for communication and problem behaviors are related. With reports from 161 adolescents and their mothers, the results indicated that the relationship between mother and adolescent reports differed by problem behavior area. Within-rater reports dominated the dimensions for communication related to aggressive behaviors. For anxious/depressed behaviors, both mother and adolescent reports contributed to the dimensions, with 1 dimension reflecting opposite perceptions of communication and adjustment by mothers and adolescents.     

Validation of Large White Pig as an animal model for the study of cannabinoids metabolism: application to the study of THC distribution in tissues

This study presents a new animal model, the Large White Pig, which was tested for studying cannabinoids metabolism. The first step has focused on determination of plasma kinetics after injection of Delta(9)-tetrahydrocannabinol (THC) at different dosages. Seven pigs received THC by intravenous injections (50, 100 or 200 microg/kg). Plasma samples were collected during 48 h. Determination of cannabinoids concentrations were performed by gas chromatography/mass spectrometry. Results showed that plasma kinetics were comparable to those reported in humans. Terminal half-life of elimination was 10.6 h and a volume of distribution of 32 l/kg was calculated. In a second step, this model was used to determine the kinetic profile of cannabinoids distribution in tissues. Eight Large White male pigs received an injection of THC (200 microg/kg). Two pigs were sacrificed 30 min after injection, two others after 2, 6 and 24 h. Different tissues were sampled: liver, kidney, heart, lung, spleen, muscle, fat, bile, blood, vitreous humor and several brain areas. The fastest THC elimination was noted in liver tissue, where it was completely eliminated in 6 h. THC concentrations decreased in brain tissue slower than in blood. The slowest THC elimination was observed for fat tissue, where the molecule was still present at significant concentrations 24 h later. After 30 min, THC concentration in different brain areas was highest in the cerebellum and lowest in the medulla oblongata. THC elimination kinetics noted in kidney, heart, spleen, muscle and lung were comparable with those observed in blood. 11-Hydroxy-THC was only found at high levels in liver. THC-COOH was less than 5 ng/g in most tissues, except in bile, where it increased for 24 h following THC injection. This study confirms, even after a unique administration, the prolonged retention of THC in brain and particularly in fat, which could be at the origin of different phenomena observed for heavy users such as prolonged detection of THC-COOH in urine or cannabis-related flashbacks. Moreover, these results support the interest for this animal model, which could be used in further studies of distribution of cannabinoids in tissues.     

Temperature-dependent development of Ophyra aenescens (Wiedemann, 1830) and Ophyra capensis (Wiedemann, 1818) (Diptera, Muscidae)

The influence of rearing temperature on the development rates of two "dump flies" Ophyra aenescens (Wiedemann, 1830) and Ophyra capensis (Wiedemann, 1818) is analysed. The development times of these species are determined. Flies were reared at three constant temperatures (17+/-1, 24+/-1 and 30+/-1 degrees C) with a photoperiod of 12:12 and at a relativity moisture of 75-95%. The minimum duration for each development stages, from eggs to pupae and from eggs to adult emergence of O. aenescens and O. capensis are reported. The development rate increases in both species as the rearing temperature rises. A temperature-dependent development model is calculated for each species. The larval and total development of these two species can be estimated if the environmental temperature is between 17 and 30 degrees C. Compared to O. aenescens, O. capensis has a higher threshold of development and a longer larval development time.