The course of respiration and circulation in death by carbon dioxide poisoning

To investigate the effects of very high concentrations of carbon dioxide (CO2) upon the course of respiration and circulation, dogs were allowed to breathe high concentrations of CO2 while intrathoracic pressure, blood pressure (BP) in the femoral artery, electrocardiogram and electroencephalogram readings were registered. The respiratory movements either increased just after inhalation of high concentrations of CO2 and then ceased in 1 min, or decreased and continued for a while according to the concentrations of CO2. The BP showed an initial depression, then returned to the original level, then fell again rapidly or maintained an appreciable level for a while until circulatory breakdown. In the dogs allowed to breathe the gas mixture of 80% CO2 with 20% O2, the respiratory movement ceased in 1 min, and the terminal respirations were seen with the circulatory breakdown after apnoea of several minutes. These findings showed that the cause of death in breathing high concentrations of CO2 is not hypoxia, but the CO2 poisoning.     

Apoptotic and necrotic brain lesions in a fatal case of carbon monoxide poisoning

A 41-year-old man was accidentally exposed to carbon monoxide (CO) gas and found in a state of cardiopulmonary arrest while he took bath. After admission, he was resuscitated and underwent artificial ventilation in a comatose state and died about 19h later. Computed tomography (CT) examination disclosed bilateral low density area in the basal ganglia and the thalamus, a well-known finding in the CO intoxication. Necropsy, histological examination, DNA ladder assay gave the first line of evidence for the presence of apoptosis as well as necrosis in the human case of CO intoxication. TdT-mediated dUTP-biotin nick-end labeling (TUNEL) positive apoptotic cells were more predominant in the CA2 area than in CA1 area. There is general co-relation between the ratio of TUNEL-positive cells and the DNA laddering on the agarose gel. Basal ganglia and thalamus, which showed bilateral low density area in CT, were revealed to be severe edema. The two types of cell death occurred in the cortex, basal ganglia, hippocampus, thalamus, and cerebellum. Hypoxia caused by CO-hemoglobin formation alone cannot explain the phenomena.     

An experimental study of death in a reverse suspension.

To investigate the course of respiration and circulation in a head-down position, 14 rabbits were set in reverse suspension. The respiratory rate increased a little, but the amplitude of the respiratory movements did not change in the beginning of the experiment. The amplitude of respiratory movements then began to reduce gradually, and toward the end of the experiment, it reduced suddenly. PaO2 increased in the beginning of the experiment and then began to decrease in accordance with the reduction of the amplitude of the respiratory movements. The blood pressure decreased with relation to the decrease of PaO2 resulting from the reduction of the amplitude of the respiratory movements. All rabbits died in 17 to 44 hours (average, 26 hours). The results suggested that the cause of death in a head-down position is due to postural asphyxia resulting from hindered respiratory movements, and that it is possible to survive for at least half a day in a head-down position.     

A death due to perirenal hematoma complicating extracorporeal shockwave lithotripsy

Perirenal hematoma is an occasional complication of extracorporeal shockwave lithotripsy (ESWL) which does not usually require treatment. A 79-year-old woman died 23 h after ESWL. Forensic autopsy was performed to determine whether medical treatment contributed to her death. The cause of death was hemorrhagic shock due to massive hematoma from a ruptured small vein in the perirenal adipose capsule. No injury to other organs was found and the patient had neither coagulation abnormality nor venous disease. Perirenal hematoma can easily be diagnosed with abdominal sonography, if pain or symptoms of anemia develop. Doctors must be aware of the possibilities of severe renal hematomas after ESWL.     

Every session counts: The differential impact of previous programmes and current programme dosage on offender recidivism

Purpose. The present study examined the impact of current treatment dosage on recidivism among offenders. Methods. Using a sample of dropouts from a community treatment programme, current treatment dosage and past completed programmes were used to predict criminal recidivism. Results. After statistically controlling for risk levels, only current dosage was predictive of recidivism. Conclusions. Offenders’ current direction, indicated by current dosage, is central to reducing recidivism. Strategies for offenders completing treatment sessions are discussed.     

Determinants of Happiness in Japan and the Netherlands: Macro and Micro Analysis and Comparison

It is often said that the Japanese happiness is lower than that of Europeans. However, sufficient discussion has yet to take place with consideration of differences in social forms as a background factor. In this study, therefore, by leveraging comparative international surveys, we empirically study and compare the factors that affect happiness in Japan and in the Netherlands, a country which has a higher happiness level than other European countries, from both macro (country level) and micro (individual level) perspectives.

This paper focuses on life evaluation as happiness. It was confirmed through the results of our macro analysis that social support (i.e., having relatives or friends you can count on to help you when you are in trouble) is the factor that significantly improves the level of life evaluation both in Japan and the Netherlands compared to other countries. In addition, change of the logarithmic value of GDP per capita in Japan is negative and statistically significant, which coincides with the Easterlin Paradox claim that more income does not bring greater happiness. On the other hand, we were unable to confirm the Easterlin Paradox in the Netherlands, in which change of the logarithmic value of GDP per capita is positive, though not statistically significant. Furthermore, our longitudinal data analysis in this paper also revealed that healthy life expectancy and generosity are insignificant, although their significance has been claimed in earlier studies (e.g. Helliwell et al, 2017).

Although our macro analysis found social support is important both for Japanese and Dutch happiness on average, the results of our micro analysis have revealed different views and structure of society; the Netherlands is a welfare society in which the public sector and the citizens support each other, and Japan is a welfare society which is based on support provided by community including families and the local area. In other words, the Netherlands showed greater trust on others in general (general trust) than Japan, and Japan showed greater trust on families (family trust) than the Netherlands, a factor that had an influence on happiness levels of individuals in the respective countries. That is, while the Netherlands’ vision of a welfare society is based on “individuals and the public,” under which the independent citizens take the initiative in supporting each other, Japan’s vision of welfare society is based on “community,” under which families have a duty to support each other. In Japan, where freedom of choice is more limited than in the Netherlands, people who have more freedom of choice were found to be happier.

In order to improve happiness in both countries, we need to strengthen social support based on their respectively unique visions of welfare society rather than resorting to income-boosting economic policies. In doing so, the key for Japan would be whether or not the system can be reformed in such a way as to allow freedom of choice to individuals.     

A case of homicidal intoxication by chloropicrin

An 18-year-old girl and her boyfriend were sprayed with toxic chemicals from the left front door of their parked car. The girl died of intoxication about 4 h later. The main findings of postmortem examination were spotty discolorations on her skin and severe pulmonary edema. The unknown chemical was identified as chloropicrin by gas-liquid chromatography and gas chromatography-mass spectrometry of her lung and on samples from the car's console box, cassette tape case, and floor mat, all of which were wet with chemicals. The content of chloropicrin in her lung was calculated at 1.6 ng/g of wet weight.     

Positive and negative ion mass spectrometry of benzophenones, the acid-hydrolysis products of benzodiazepines

Positive electron impact (EI), positive chemical ionization (CI), and negative CI mass spectra of 14 benzophenones are presented. In the positive EI mode, intense molecular peaks appeared for most compounds; some other peaks due to splitting at both sides of the carbonyl group also appeared. In the positive CI mode, [M + 1]+ quasi-molecular ions together with [M + C2H5]+ peaks were observed for all compounds; some fragment peaks were common to those in the positive EI mode. In the negative CI mode, the spectra were much simpler than those in the positive EI or CI mode. In the 1 Torr negative CI mode, some spectra showed only single molecular anions; in the 0.01 Torr negative CI mode, halogen or nitro peaks appeared in addition to the molecular anions. An extraction procedure for benzophenones from human urine and plasma after heating in strong acid, and their separation by gas chromatography (GC) are also presented to serve for their actual identification by GC/mass spectrometry.