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Ray DA Walker JA Hall A Llewellyn B Ballantyne J Christian AT Turteltaub K Batzer MA 《Forensic science international》2005,153(2-3):117-124
The inference of an individual's geographic ancestry or origin can be critical in narrowing the field of potential suspects in a criminal investigation. Most current technologies rely on single nucleotide polymorphism (SNP) genotypes to accomplish this task. However, SNPs can introduce homoplasy into an analysis since they can be identical-by-state. We introduce the use of insertion polymorphisms based on short interspersed elements (SINEs) as a potential alternative to SNPs. SINE polymorphisms are identical-by-descent, essentially homoplasy-free, and inexpensive to genotype using a variety of approaches. Herein, we present results of a blind study using 100 Alu insertion polymorphisms to infer the geographic ancestry of 18 unknown individuals from a variety of geographic locations. Using a Structure analysis of the Alu insertion polymorphism-based genotypes, we were able to correctly infer the geographic affiliation of all 18 unknown human individuals with high levels of confidence. This technique to infer the geographic affiliation of unknown human DNA samples will be a useful tool in forensic genomics. 相似文献
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The collapse ofcommunism has not. as might be expected, led to the end of ideologies. Instead of the grand rcvolutionary projects of the past, however, we now have a set of overlapping fragments of revelation which cooperatc with each other in social transformation. These fragments exhibit an 'identity monism' which can tell us something about the character of ideology in general. This form of monism is the necessary condition of turning a modern state into a managed enterprise for the satisfaction of human needs-a project which happens also to be adumbrated in much normative political philosophy. A managed civil state responds to opinion rather than interest. and the opinions on which the project rests commend themselves by some version of self-evidence. 相似文献
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A basic median-voter model is developed and extended to analyze issues of economic regulation and public policy outcomes. The model is used to generate comparative static results relating changes in public-policy outcomes to changes in relative group sizes, total population, information costs, and population heterogeneity. The model is also used to explore the issue of optimal group size — the size of the special-interest group that maximizes the group's per capita public policy gains. Comparative static analysis reveals how optimal group size and gains per capita are affected by changes in population heterogeneity, the size of the total population, and relative knowledge levels. 相似文献
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