Confirmation by LC-MS of drugs in oral fluid obtained from roadside testing

The aim of this study was to assess the effectiveness of two current on-site oral fluid (OF) drug detection devices (OraLab and Dr?ger), as part of the Spanish participation in the Roadside Testing Assessment Project (ROSITA Project). The study was done in collaboration with the Spanish Traffic Police, in Galicia (NW Spain), during 2004 and 2005. A total of 468 drivers selected at the police controls agreed to participate through informed consent. In addition, saliva samples were collected and sent to the laboratory to confirm the on-site results. For this purpose, two different analytical liquid chromatography-mass spectrometry (LC-MS) methods were used to detect 11 drugs or metabolites in a 300 microL sample. Simultaneous analysis of morphine, 6-acetylmorphine, amphetamine, methamphetamine, MDA, MDMA, MDEA, MBDB, cocaine and benzoylecgonine was carried out using 100 microL of oral fluid, after an automated solid phase extraction. A different LC-MS method was performed to detect Delta(9)-THC in 200 microL of oral fluid using liquid-liquid extraction with hexane at pH 6. Both methods were fully validated, including linearity (1-250 ng/mL, 2-250 ng/mL) recovery (>50%), within-day and between-day precision (CV<15%), accuracy (mean relative error<15%), limit of detection (0.5 and 1 ng/mL), quantitation (1 and 2 ng/mL) and matrix effect. All of the positive cases and a random selection of 30% of the negatives were analyzed for confirmation analysis. Good results (sensitivity, specificity, accuracy, positive predictive value and negative predictive value>90%) were obtained for cocaine and opiates by OraLab, and for cocaine by Dr?ger. However, the results for the other compounds could be improved for both detection devices. Differences in the ease of use and in the interpretation mode (visual or instrumental) were observed.     

On Some Merits of the Israeli Judgment on Targeted Killings

The recent judgment by the Israeli Supreme Court on targetedkillings is a landmark decision in many respects. Its main meritlies in trying to give precision to, and therefore make concretelyapplicable by the belligerents, some loose standards of internationalhumanitarian law on the conduct of hostilities. In particular,the judgment is significant because (i) it concluded that theissue of targeted killings did not amount to a non-justiciablequestion, (ii) it suggested a novel and imaginative way of narrowingdown the vague scope of imprecise international rules on methodsof combat, and in addition (iii) it set out a range of measuresthat belligerents must take both before and after armed attacksagainst civilians participating in hostilities, so as to avoiddamage to innocent civilians as far as possible. The measuresauthoritatively suggested in the judgment may serve both toturn some unclear international rules into workable standardsof conduct, and also to open the way to the possible prosecutionof individuals (superiors and subordinates) who do not complywith such standards.     

Evaluating a natural experiment in alcohol policy

Research Summary
This study examines the effects of a dramatic change in alcohol licensing policy on the practice of liquor retailing across a metropolitan urban region. The policy was enacted to remove fixed closing times and to install staggered closing times across regions where it potentially would reduce violent crime and disorder. We found great variation in the extent to which the provisions of the policies were installed as intended.
Policy Implications
The findings suggest that prior consideration for how policy interventions will be applied to real-world settings is important to the validity of research evaluations. Understanding and monitoring variation in the implementation of an intervention is a vital prerequisite to the evaluation of outcomes. Without knowledge of the real-world application of an intervention, researchers risk attributing causal effects to a prevention initiative that might have been absent or only partially received.     

PMICALC: An R code-based software for estimating post-mortem interval (PMI) compatible with Windows,Mac and Linux operating systems

In legal medicine the correct determination of the time of death is of utmost importance. Recent advances in estimating post-mortem interval (PMI) have made use of vitreous humour chemistry in conjunction with Linear Regression, but the results are questionable. In this paper we present PMICALC, an R code-based freeware package which estimates PMI in cadavers of recent death by measuring the concentrations of potassium ([K+]), hypoxanthine ([Hx]) and urea ([U]) in the vitreous humor using two different regression models: Additive Models (AM) and Support Vector Machine (SVM), which offer more flexibility than the previously used Linear Regression. The results from both models are better than those published to date and can give numerical expression of PMI with confidence intervals and graphic support within 20 min. The program also takes into account the cause of death.     

Isolating Target And Neighbourhood Vulnerabilities In Crime Forecasting

Risk terrain modelling (RTM) is emerging as an effective approach for predicting how and where crimes concentrate within cities and regions. However, in its previous applications there is a tendency to overestimate the influence of external environmental risks and preventive factors. Most studies applying RTM have investigated factors associated with the characteristics of the urban setting, whilst only a limited number have focused on identifying the risks associated with the availability and the characteristics of potential targets for criminals. This study uses RTM to identify the spatial risk and protective factors related to residential burglaries in the city of Milan, Italy. Factors considered are the neighbourhood- and target-related contextual factors, the exposure to crime and potential mitigating strategies. The results show that when the place and target of the offence are intrinsically related a target-oriented approach to select factors is useful for increasing the understanding of why some locations are most likely to experience future crimes. Indeed, the peculiarities of the target itself are integral to understan both the decision-making of criminals and the overall level of crime risk. Related policy implications are discussed.     

The Silent Reform of Swiss Federalism: The New Constitutional Articles on Education

This article examines the decision‐making process leading to the new constitutional articles on education in Switzerland. It analyzes how actors from both state levels (Confederation and cantons) could reach consensus in a process that was prone to a “joint‐decision trap”. To that end, we hypothesize which factors may be conducive to a “problem‐solving” style of policy‐making in a compulsory negotiation system. Rich empirical material from various sources supports our theoretical arguments: We show that shared beliefs and a common frame of reference, the procedural separation between constitutional and distributional issues, neutral brokers, and informal structures were all beneficial to the success of the reform project.     

Centre–periphery relations in Afghanistan: Badakhshan between patrimonialism and institution-building

The article offers a review of centre–periphery relations and local politics in the Afghan province of Badakhshan from the 1980s to the post-2001 era. It maps the local powerbrokers and charts the transformations that occurred during this period, with particular reference to the impact of the central government's policies on local political alignments and relations of power. The key argument is that President Karzai's and the cabinet's behaviour towards Badakhshani politics was aimed at re-establishing a patrimonial system, rather than at institution-building as claimed. Unable or unwilling to successfully deal with established local players, Kabul resorted to sponsoring new players in local politics and facilitating their rise in order to weaken more independent powerbrokers. However, a local perception of weakness in Kabul, not least due to uncertainty over the durability of the Karzai administration, led local players, old and new, to behave with very short-term horizons, as ‘roving bandits’ rather than as ‘stationary’ ones.     

Bureaucratic Job Mobility and The Diffusion of Innovations

In studies of innovation, policy entrepreneurs recognize latent demand for new policies and then expend resources to promote them. But studies of policy entrepreneurs have generally focused on the demand for innovation, while neglecting the supply side of policy entrepreneurship. This article argues that bureaucratic labor markets affect the emergence of policy entrepreneurs, and so affect the diffusion of policy innovations across local governments in the United States. Analysis of a survey of municipal police chiefs and water utility managers relates governments' hiring and promotion policies to their adoption of professionally fashionable innovations. Agency heads who advanced to their current positions diagonally (arriving from another organization) are more likely to initiate these innovations than are agency heads who were promoted from within. Bureaucratic policy entrepreneurs emerge where government demand for innovation meets a supply of mobile administrators, who carry the priorities of their professions into the agencies that they serve.     

The Role of Ego-Resiliency as Mediator of the Longitudinal Relationship between Family Socio-Economic Status and School Grades

Family socio-economic status (SES) represents one of the major determinants of youth’s scholastic achievement, and thus it is important to unravel the psychological factors underlining this relation. In this article, we examined youth’s ability to flexibly adapt and, thus, cope with harsh environmental conditions—assessed by the construct of ego-resiliency—as a mediating mechanism in the across-time association between family SES and academic achievement. The longitudinal sample was composed of 265 (56% females) Italian students who were about 13 years old at Time 1 (T1) and about 18 years old at Time 2 (T2). In a structural equation model analysis, family SES significantly predicted ego-resiliency 6 years later while controlling for the latter’s strong longitudinal stability. Students’ school grades at the end of senior high school were also predicted by ego-resiliency assessed at the age of 13, controlling for grades in the last year of junior high school, gender, and initial differences in ages. In accordance with the posited hypothesis, this study provided support for a two-wave meditational model in which the relation between family SES at 13 years and later school grades at 19 years was mediated by ego-resiliency. All in all, results support the argument that being resilient, and thus being able to flexibly adapt one’s own emotional state and resultant behavior, matters to school success.