膜攻击复合物对继发性脑损伤的影响

脑损伤后普遍存在的炎性反应激活补体并通过多种途径导致和加重继发性脑损伤。膜攻击复合物具有直接破坏血脑屏障、促使红细胞溶解、促进释放细胞因子、氧自由基和金属基质蛋白、加剧炎症反应的生物特性,从而加重继发性脑损伤。本文对膜攻击复合物造成继发性脑损伤的研究进行综述,希望能对相关研究和法医学鉴定提供参考。     

Mixing Habermas with Bayes: Methodological and Theoretical Advances in the Study of Deliberation

Two challenges stand out in the study of deliberation: the development of appropriate methodological tools and the development of more unified analytical frameworks. On the one hand, analysing deliberative processes is demanding and time‐consuming; hence we tend to have only few and non‐randomly selected cases at the group or context level. In addition, the real world of deliberation presents us with a complex matrix of nested, cross‐classified, and repeated speakers. This article shows that Bayesian multi‐level modelling provides an elegant way to tackle these methodological problems. On the other hand, we attempt to enrich comparative institutionalism with individual characteristics and psychologically relevant variables (such as group composition). Focusing on Swiss and German parliamentary debates we show that institutional factors ‐ in particular, consensus systems ‐, the gender composition of committees and plenary sessions, and age matter for the quality of deliberation. Furthermore, we also show that partisan affiliation ‐ government or opposition status of MPs ‐ affects deliberative quality and can refine institutional arguments. We conclude that a multi‐level approach to deliberation focusing on contextual and actor‐related characteristics and using Bayesian hierarchical modelling paves the way toward a more advanced understanding ‐ and methodological handling ‐ of deliberative processes.     

The cognitive and affective components of political attitudes: Measuring the determinants of candidate evaluations

Past research suggests that beliefs and emotions operate as partially distinct determinants of political attitudes. In addition, while positive and negative beliefs about a political object are bipolar in structure, positive and negative emotions have been demonstrated to be relatively independent. In this past research, beliefs and emotions have been assessed with different measures. Yet current models of survey responding suggest that responses to survey items are often influenced by the manner in which the researcher poses the questions. As such, it is not clear whether the uniqueness of these belief and emotion measures reflects a bona fide difference between two underlying constructs, or merely an artifactual difference induced by differing methods of measurement. In this study, beliefs and emotions are shown to operate as partially unique predictors of candidate evaluation even when employing corresponding methods of measurement. The independence of positive and negative emotion, however, only arises when employing a dichotomous measure. When employing ordinal measures, positive and negative emotions contain a substantial component of bipolarity. The theoretical implications of these findings are discussed.     

What is the best sample for determining the early postmortem period by on-the-spot flow cytometry analysis?

The level of degradation of DNA as a means for determining the time of death has been proposed as a valid adjunct to the classic thanatochronologic methods. The twofold aim of this work was to determine which organ might reveal both a correlation between the percentage of degradation of the DNA and the time lapse since death, and would be easiest to sample and yield the most reproducible results even in technically unfavorable situations such as on-the-spot investigations at the scene of death. A comparison of the spleen, blood, and liver showed that hepatic tissue best meets these specific needs because it shows a virtually linear correlation between the time elapsed since death and the level of degradation of the DNA, and it can easily be sampled at the scene of death by use of a common biopsy needle.     

A fatal case of cocaine poisoning in a body packer

A 27-year-old man was carrying in his digestive tract 99 packages each containing about 10 g of a 86% cocaine powder. The courier died by acute cocaine intoxication due to inflation and rupture of four packages during a flight from Bogotá to Rome. At the autopsy, the external examination was unremarkable. The internal examination showed edema and generalized congestion of the organs. Toxicological analyses were performed by gas chromatography-mass spectrometry after solid phase extraction using Bond Elut Certify columns and derivatization with BSTFA/TMCS. High levels of cocaine and benzoylecgonine were found in blood (4.0 microg/mL and 17.0 microg/mL), urine (152.0 microg/mL and 512.0 microg/mL), bile (99.8 microg/mL and 54.0 microg/mL), vitreous humor (7.1 microg/mL and 5.8 microg/mL), brain (7.5 microg/mL and 3.5 microg/mL), and hair (55.5 ng/mg and 27.7 ng/mg). The presence of the cocaine and its metabolite in the hair suggested that the man was a cocaine user.     

Bile analysis of drugs in postmortem cases

Bile is, in certain cases, collected together with blood from different sites (heart, brain, femoral), urine and other organs or matrices. This study reports comparative results obtained from the analysis of blood and bile for different drugs found: acetaminophen, amphetamine and related compounds, several antidepressants, several benzodiazepines, cocaine and its metabolites, dextropropoxyphene and its metabolite, hydroxyzine, methadone and metabolite, morphine and codeine, levomepromazine, thioridazine, propranolol, tramadol and its metabolite. Several findings are presented: (1) There were no significant differences in the levels of the compounds among the samples of blood obtained from different sites. (2) Levels in bile are generally several fold higher than those in blood. The mean bile to blood ratios vary from about 1 (for acetaminophen, amphetamine) to about 2000 (for desmethylclobazam). (3) In certain cases (16 over 44), although the drug or its metabolite was not detected in blood from different sites, it was detected in bile. As other authors had advocated, it is very useful to ask the pathologist to take the gall bladder with its contents together with the other samples, in order that the sample of bile can be used in the comprehensive toxicological analysis and therefore be complementary to the other fluids or matrices. An additional advantage for using bile is that the concentrations of drugs or their metabolites are generally several fold higher than their blood concentrations.     

欧盟宪法危机的成因、影响及出路

欧洲迎来了历史上前所未有的和平统一的机会,欧元的成功已进一步地把欧洲的经济融合到一起。政治上,欧盟宪法的起草也给人们以巨大的希望,人们希望看到一个统一、和平的欧洲出现。但在2005年,法国和荷兰先后在全民公决中,否定了《欧盟宪法》,这给欧洲统一的进程蒙上了阴影。本文尝试分析此次危机出现的原因,并进一步探讨危机出现可能带来的影响,以及预测今后欧洲一体化的前景。     

关于《网络著作权》的法律问题

本文界定了网络著作权侵权,探讨了网络著作权的管辖问题、法定许可问题、侵权行为的表现形式以及侵权的责任及赔偿标准等问题。