Glucose and lactate in vitreous humor compared with the determination of fructosamine for the postmortem diagnosis of diabetes mellitus

Diabetes mellitus is a chronic metabolic illness responsible for a great number of deaths. In postmortem diagnosis, because of the difficulty involved in interpreting blood glucose levels and relatively nonspecific pathologic features, biochemical markers in vitreous humor are useful. The aim of this study was to compare the results obtained for the combined determination of lactate and glucose with fructosamine levels recorded in the vitreous humor of two diagnostic groups (one diabetic and the other nondiabetic). The authors intended to ascertain the capacity of different markers measured in vitreous humor to diagnose diabetes mellitus. Fifty-one cadavers (mean age, 58.7 years; standard deviation, 17.09) were studied. The mean postmortem interval was 16.4 hours (standard deviation, 9.05). Cases were assigned to two diagnostic groups according to whether they were previously diagnosed as either diabetic or nondiabetic. Statistically significant differences for glucose, fructosamine, and the sum values of glucose and lactate were found between the two diagnostic groups. The highest levels were obtained in the group of cases with a previous diagnosis of diabetes mellitus. After the comparison of receiver operating characteristic curves, the sum values of glucose and lactate in vitreous humor is a better predictor of antemortem diabetes mellitus than the fructosamine.     

Writing from Experience: The Place of the Personal in French Feminist Writing

Through a discussion of the work of Marie Cardinal and Annie Ernaux, this article aims to problematize the anglophone academic world's tendency to associate French feminisms predominantly with avant-garde or highly theoretical texts. The work of Ernaux and Cardinal is presented alongside a discussion of its reception by readers and critics in France, and by academics in English-speaking countries. The first part of the article identifies aspects of Ernaux's and Cardinal's works which cannot be encompassed within a critical framework based on the dichotomy between naive realism on the one hand and the politically and linguistically radical text on the other. Ernaux's plain language, for instance, is clearly very unlike the linguistic experimentation of ‘feminine writing’ nonetheless the emphasis on social class in her writing constitutes a political intervention which is at least equally valid.The reception study in the second part of the article provides further evidence of the relevance to gender politics in France of Cardinal's The Words to Say It (1975) and texts published by Annie Ernaux in the 1980s and 1990s. The ambivalent response of critics seems to indicate the troubling nature of writing which combines the codes of realism and autobiography (or autobiographical fiction in Cardinal's case) with the depiction of taboo subjects such as menstruation, or a daughter's response to her mother's debilitating illness and death. The article also charts the widespread popularity of these texts in France, particularly with women readers, and gives some examples of the pleasures described in letters to the authors. In conclusion, we argue that the ambivalent space between popular and high culture occupied (albeit differently) by Ernaux and Cardinal may be particularly effective in terms of gender politics, and that even in the late 1990s, the personal may be as political as ever.     

A Call to Action—The Essential Role of Advocacy

Editor's Note: The Perspectives featured in this issue of Public Administration Review were adapted from May 2016 commencement addresses: Anna Maria Chavez, the CEO of the Girl Scouts of the USA, spoke on the 12th at Arizona State University's College of Public Service and Community Solutions; Nancy Pelosi, the Democratic Leader in the United States House of Representatives spoke on the 7th at New York University's Wagner School of Public Service; and Tommy Thompson, the former Governor of Wisconsin and Secretary of Health & Human Services, spoke on the 15th at the University of Wisconsin's La Follette School of Public Affairs. These Perspectives reaffirm the highest principles of American public administration: that by and large, government is NOT the problem, and quite often indeed holds the solution; that effective and helpful public policy depends on informed expert opinion and research; and that those who enter public service should do so with a commitment to the notion that America best fulfills its promise when we seek the well‐being of all people, including the least fortunate. We chose these messages from among a wealth of commencement speeches because while they come from leaders with quite different political views, background, and experience, taken together they offer a coherent and inspiring call to public service. Dan Feldman, Perspective and Commentary Editor     

Isotope ratio mass spectrometry as a tool for forensic investigation (examples from recent studies).

The versatility of isotope ratio mass spectrometry is demonstrated by reference to diverse case studies. Variations in the natural isotopic composition of non-biological, organic materials are compared as a means by which samples may be associated or discriminated. These techniques may be used to augment or compliment conventional forensic methodologies. delta13C analysis was used to demonstrate that different masking tape had been recovered in two, apparently similar cases, involving the smuggling of money. Visually similar ecstasy tablets were compared by consideration of the delta13C and delta15N composition of MDMA extracted from the tablets. Although only a limited number of tablets were analysed, the isotopic similarity between two different seizures was sufficient to induce a guilty plea from a person suspected of possessing both. A combination of delta2H, delta13C, delta15N and delta18O together with GC-MS analyses were applied to small samples of seized heroin. Although GC-MS analysis indicated differences between the chemical composition of two of the heroin samples, isotopic analysis suggested similarities, which were confirmed by further delta2H, delta13C and delta18O isotopic analysis of the clingfilm in which the samples were wrapped.