Ontogeny of Size and Shape Sexual Dimorphism in the Pubis: A Multislice Computed Tomography Study by Geometric Morphometry

Few studies have been conducted to determine sex differences in the immature coxal bone and the results were often contradictory. The authors studied sexual dimorphic differences of the pubis using geometric morphometric analysis of five osteometric landmarks recorded by multislice computed tomography (MSCT), based on three‐dimensional reconstructions of 188 children (95 boys, 93 girls) living in the region of Toulouse, southwestern France, ranging in age from 1 to 18 years old. They used geometric morphometric methodology first to test sexual dimorphism in size (centroid size) and shape (Procrustes residuals) and second to examine patterns of shape change with age (development) and size change with age (growth). Based on statistical significance test results, the pubic shape became sexually dimorphic at 13 years old, although visible shape differences were observed as early as 9 years old. This work showed that the trajectories of pubis shape (development) and size (growth) differed throughout ontogeny and between sexes.     

The political economy of regional integration in East Asia

A widely held consensus view claims that East Asia has been shifting recently from a market-led to an institution-based form of regional economic integration, primarily as a result of the 1997–1998 financial crisis. Next to post-crisis financial cooperation schemes under the ASEAN+3, the surge of Regional Trade Agreements (RTAs) involving East Asian countries is thought by some to further substantiate this claim. The objective of the paper is to question the validity of this claim. By examining the current state of play of economic cooperation, in the financial and monetary areas as well as in the trade sphere, the paper highlights the limitations of the formal regional integration movement in East Asia to date, as well as the vastly different dynamics underlying the financial and trade developments. It also explores the changing nature of intra-regional trade and investment linkages and concludes that this new form of interdependence may be instrumental in changing the trade-offs of formal regional economic schemes.     

人口和政治

摆脱某些禁忌长久以来,禁忌和幻影阻碍了人们对政治与人口之间联系的严肃思考。在所有人的想象中,至少在社会精英中,这种联系揭示了一个人口政策是军事实力的杠杆的时代。二十世纪20、30年代的法西斯政体实际上促使了具有侵略性的生育政策向以实现领土征服为目的的战略转变。     

Coalition politics and the making of Indian foreign policy: a new research program

ABSTRACT

Do Indian regional parties influence foreign policy and under which conditions? Some foreign policy studies have shown that certain coalition-building configurations have facilitated the inclusion of the concerns of small parties in the foreign policy debate. Other works have looked at the role of decentralization and federal power-arrangement in providing more control to political sub-units over the external affairs of a state. Those separate scholarships provide interesting insights to account for the multi-level nature of coalition-building in a federal and pluralistic polity like India. Bridging these two literatures, I argue that the interdependence of regional and national coalition building processes (visible in federal settings) create locked-in alliances between national parties and regional parties which affect foreign policymaking. In these contexts, India’s national parties have to, under certain conditions, take into account the preferences of regional parties when designing foreign policies. This article looks at the hypothesized causal mechanisms and expectations through two illustrative case studies of India’s foreign policy.     

Methods for detection and confirmation of Hematide™/peginesatide in anti-doping samples

Since the 1990's, cheating athletes have abused substances to increase their oxygen transport capabilities; among these substances, recombinant EPO is the most well known. Currently, other investigational pharmaceutical products are able to produce an effect similar to EPO but without having chemical structures related to EPO; these are the synthetic erythropoiesis stimulating agents (ESAs). Peginesatide (also known as Hematide?) is being developed by Affymax and Takeda and, if approved by regulatory authorities, could soon be released on the international market. To detect potential athletic abuse of this product and deter athletes who consider cheating, we initiated a collaboration to implement a detection test for anti-doping purposes. Peginesatide is a synthetic, PEGylated, investigational, peptide-based erythropoiesis-stimulating agent that is designed and engineered to stimulate specifically the erythropoietin receptor dimer that governs erythropoiesis. It is undetectable using current anti-doping tests due to its lack of sequence homology to EPO. To detect and deter potential abuse of peginesatide, we initiated an industry/antidoping laboratory collaboration to develop and validate screening and confirmation assays so that they would be available before peginesatide reaches the market. We describe a screening ELISA and a confirmation assay consisting of immune-purification followed by separation with SDS-PAGE and revelation with Western double blotting. Both assays can detect 0.5 ng/mL concentrations of peginesatide in blood samples, enabling detection for several days after administration of a physiologically relevant dose. This initial report describes experimental characterization of these assays, including testing with a blinded set of samples from a clinical study conducted in healthy volunteers.     

Restrictions of the sale of pharmaceuticals and medical devices such as contact lenses over the internet and the free movement of goods

In the light of new case law development, this article examines whether national restrictions on the online sale of pharmaceuticals and medical devices such as contact lenses are consistent either with EU secondary law, either with Article 34 TFEU that prohibits measures having equivalent effect to quantitative restrictions on imports. In particular, this article focuses on an analysis of two judgments on this important issue delivered by the Court of Justice of the European Union in 2003 and 2010, namely the Deutscher Apothekerverband decision and the Ker-Optika decision.