Editorial

Ohne Zusammenfassung

---

Editorial

     

Organized interests and administrative rulemaking: the state of Wisconsin's lobbyists and coalitions

This study examines interest groups undertaking lobbying activity focused on administrative rulemaking. The analysis utilizes a dataset composed of observations made during the 2009–2010 Wisconsin Legislative Session, including the entire population of groups lobbying during this time period. This research examines the participants, efforts, and coalitions utilized when groups engaged in lobbying activity related to rulemaking. Although scholars have examined interest group activity focused on rulemaking at the federal level, little work has focused on this behavior in the states. This study aims to further the understanding of this activity. Copyright © 2015 John Wiley & Sons, Ltd.     

Reaching beyond the health post: Community-based surveillance for polio eradication

This article discusses the CORE Group Polio Project Ethiopia's introduction of community-based surveillance (CBS) of acute flaccid paralysis (AFP) to support polio eradication. A USAID-funded collaboration among Ethiopian and US-based NGOs, the CGPP supports volunteers in education about AFP and encouraging case reporting. Volunteers also conduct active case searches, visiting community leaders likely to have contact with paralysis cases. The project's methods strengthen communities' awareness of AFP and their connection to the health system. Data indicate a near doubling of AFP reporting in project areas since the implementation of CBS, according to MOH-E (Ministry of Health, Ethiopia)/WHO statistics.

Allant au-delà du poste de santé: surveillance communautaire pour éradication de la poliomyélite

Cet article traite de l'introduction par le Projet sur la polio du CORE Group (CGPP) en Éthiopie de la surveillance communautaire (SC) de la paralysie flasque aiguë (PFA) pour soutenir l’éradication de la polio. Le CGPP, collaboration financée par USAID entre ONG éthiopiennes et basées aux États-Unis, aide des volontaires à mener une éducation sur la PFA et à encourager la notification des cas. Les volontaires effectuent aussi des recherches actives de cas, rendant visite aux leaders communautaires susceptibles d’être en contact avec des cas de paralysie. Les méthodes du projet renforcent la prise de conscience par les communautés de la PFA et leurs liens avec le système de santé. Les données indiquent que le nombre de cas de PFA signalés a presque doublé dans les zones du projet depuis la mise en ?uvre de la SC, d'après les statistiques du Ministère de la Santé, éthiopien et de l'OMS.

Llegar más allá del puesto de salud: vigilancia comunitaria para erradicación de la poliomielitis

Este artículo examina el Proyecto contra la Poliomielitis llevado a cabo en Etiopía por CORE Group (CGPP por sus siglas en inglés), así como el uso que realiza del método de vigilancia comunitaria (VC) para el seguimiento de la parálisis flácida aguda (PFA). El objetivo de este proyecto es erradicar la polio. Constituye un esfuerzo conjunto de ONG etíopes y estadounidenses, financiado por USAID. CGPP apoya la formación de voluntarios para la vigilancia de la PFA, promoviendo la elaboración de informes sobre distintos casos. Asimismo, los voluntarios dan seguimiento a los casos vigentes, realizando visitas a los líderes comunitarios que, con frecuencia, tienen contacto con personas con parálisis. La metodología del proyecto impulsa la conciencia comunitaria en relación a la PFA y al vínculo entre las comunidades y el sistema de salud. Las estadísticas reportadas por el Ministerio de Salud de Etiopía y la OMS indican que, desde que inició la VC, se han duplicado los informes sobre PFA en las áreas abarcadas por el proyecto.

Indo além do posto de saúde: investigação baseada na comunidade para a erradicação da polio

Este artigo discute a introdução da Investigação Baseada na Comunidade sobre casos de paralisia flácida aguda (AFP) do Projeto Pólio do Grupo CORE da Etiópia, voltada para apoiar a erradicação da pólio. Uma colaboração financiada pela USAID entre ONGs baseadas na Etiópia e EUA, o CGPP apóia voluntários na educação sobre AFP e incentiva o relato de casos. Os voluntários também conduzem pesquisas de caso ativas, visitando líderes de comunidade que provavelmente tenham contato com casos de paralisia. Os métodos do projeto fortalecem a conscientização das comunidades a respeito da AFP e sua conexão com o sistema de saúde. Os dados indicam que o número de relatos de AFP nas áreas do projeto quase dobrou desde a Implementação da Investigação Baseada na Comunidade, de acordo com estatísticas da MOH-E/WHO.     

Fast LC-MS/MS method for the determination of amphetamine, methamphetamine, MDA, MDMA, MDEA, MBDB and PMA in urine

A fast method was designed for the simultaneous determination of amphetamine (A), methamphetamine (MA), PMA, MDA, MDMA, MDEA and MBDB in urine. The drugs were analysed by LC (ESI)-MS/MS, after a simple liquid-liquid extraction in the presence of the deuterated analogues. Reverse phase separation on an Atlantis dC18 Intelligent Speed column was achieved in less than 4 min under gradient conditions, and the total run time was 8 min. The method was fully validated, including linearity (1-1000 ng/mL for A, MDMA, MDEA and MBDB; 2-1000 ng/mL for MDA and PMA; 1-200 ng/mL for MA; r2>0.99 for all compounds), recovery (>80%), within-day and between-day precision and accuracy (CV and MRE<12.7% for intermediate level and ULOQ, and <17.2% for LLOQ), limit of detection (0.2 ng/mL for MDMA, MDEA and MBDB; 0.5 ng/mL for A, MA and PMA; 1 ng/mL for MDA) and quantitation (1 ng/mL for A, MA, MDMA, MDEA and MBDB; 2 ng/mL for MDA and PMA) and relative ion intensities. No matrix effect was observed. The procedure proved to be sensitive, specific and rapid, and was applied to real forensic cases.     

Confirmation by LC-MS of drugs in oral fluid obtained from roadside testing

The aim of this study was to assess the effectiveness of two current on-site oral fluid (OF) drug detection devices (OraLab and Dr?ger), as part of the Spanish participation in the Roadside Testing Assessment Project (ROSITA Project). The study was done in collaboration with the Spanish Traffic Police, in Galicia (NW Spain), during 2004 and 2005. A total of 468 drivers selected at the police controls agreed to participate through informed consent. In addition, saliva samples were collected and sent to the laboratory to confirm the on-site results. For this purpose, two different analytical liquid chromatography-mass spectrometry (LC-MS) methods were used to detect 11 drugs or metabolites in a 300 microL sample. Simultaneous analysis of morphine, 6-acetylmorphine, amphetamine, methamphetamine, MDA, MDMA, MDEA, MBDB, cocaine and benzoylecgonine was carried out using 100 microL of oral fluid, after an automated solid phase extraction. A different LC-MS method was performed to detect Delta(9)-THC in 200 microL of oral fluid using liquid-liquid extraction with hexane at pH 6. Both methods were fully validated, including linearity (1-250 ng/mL, 2-250 ng/mL) recovery (>50%), within-day and between-day precision (CV<15%), accuracy (mean relative error<15%), limit of detection (0.5 and 1 ng/mL), quantitation (1 and 2 ng/mL) and matrix effect. All of the positive cases and a random selection of 30% of the negatives were analyzed for confirmation analysis. Good results (sensitivity, specificity, accuracy, positive predictive value and negative predictive value>90%) were obtained for cocaine and opiates by OraLab, and for cocaine by Dr?ger. However, the results for the other compounds could be improved for both detection devices. Differences in the ease of use and in the interpretation mode (visual or instrumental) were observed.     

Identification of 1‐(2,3‐dihydro‐1H‐inden‐5‐yl)‐2‐(ethylamino)pentan‐1‐one (bk‐IVP) in a Seized Drug Exhibit

To circumvent the law by evading regulation and obscuring their identities in routine analyses, numerous substituted cathinones have entered the illicit drug market. These compounds have been coined “bath salts” by users. In the described case, the laboratory received an unknown white powder for controlled substances identification. The sample could not be immediately identified using standard methods and procedures. Ultimately, the structure was elucidated using GC‐MS, NMR, FTIR, GC‐SPIR, UV, and color tests to be 1‐(2,3‐dihydro‐1H‐inden‐5‐yl)‐2‐(ethylamino)pentan‐1‐one (bk‐IVP), a cathinone analog with a rarely observed nonoxygenated bicyclic ring system. Features of spectra and chemical tests are reported that distinguish this class of cathinones from heterocyclic analogs.