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Suicide is a worldwide health problem with multiple causes, including genetic factors. The major histocompatibility complex (MHC) is represented by an assembly of gene encoding the human leukocyte antigen (HLA). The purpose of our study was to determine associations between the HLA profiles and predisposition for suicidal behavior. We harvested blood samples from persons with history of suicidal attempts (case group) and persons never exhibiting such behavior (control group). The DNA was extracted and amplified via polymerase chain reaction (PCR) to determine the HLA-DQB1 profiles. Statistical data processing was performed with the Epi Info program. We found that the presence of the HLA-DQB1*02 allele increases the risk of suicidal behavior, while HLA-DQB1*05 alleviates such risk. The genotype that presented the most increased risk for suicidal behavior was found to be HLA-DQB1*02/HLA-DQB1*03. Our study has demonstrated the presence of several associations between HLA profiles and suicidal behavior.  相似文献   
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This article examines the ethical challenges encountered by European Commission officials in their day-to-day work. Based on an intra-organizational comparison between three Directorate Generals (DGs), the analysis reveals that ethical questions differ in these settings, depending on the type of external actors employees engage with. This internal heterogeneity makes the European Commission an interesting (unusual) case, which highlights the challenges of practising ethics management in a way that is truly responsive to organizational needs. The policy solution implemented by the Commission as a response—the appointment of “ethics correspondents” at DG level—has been only moderately successful.  相似文献   
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Social movements are not completely spontaneous. On the contrary, they depend on past events and experiences and are rooted in specific contexts. By focusing on three case studies – the student mobilizations of 2011 and 2013, the anti-government mobilizations of 2012, and the protests against the Rosia Montana Gold Corporation project of 2013 – this article aims to investigate the role of collective memory in post-2011 movements in Romania. The legacy of the past is reflected not only in a return to the symbols and frames of the anti-Communist mobilizations of 1989 and 1990, but also in the difficulties of the protesters to delimit themselves from nationalist actors, to develop global claims, and to target austerity and neoliberalism. Therefore, even in difficult economic conditions, Romanian movements found it hard to align their efforts with those of the Indignados/Occupy movements. More generally, the case of Romania proves that activism remains rooted in the local and national context, reflecting the memories, experiences, and fears of the mobilized actors, in spite of the spread of a repertoire of action from Western and southern Europe.  相似文献   
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Abstract

This article examines critically one of the most active regional dynamics of European security, centred on the Black Sea. Recently, the Black Sea region has received increased attention from a variety of political actors, who seek to increase the profile of the region in order to develop a common regional identity and an integrated approach to the security problems of the Black Sea region. This resurgence of the Black Sea region can be understood as the combined product of local interests, European integration and the ‘global war on terror’. The main argument of the article is that Black Sea security integration is characterised by a fundamental contradiction between two different logics of security—geopolitical and institutional. Three other problems—transposition, fragmentation, and duplication—are also discussed. In the conclusion, the article examines the significance of the efforts to build the Black Sea region for the future of regional integration in European security.  相似文献   
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The Journal of Technology Transfer - Over the past 15 years, accelerators emerged as a popular and distinct new form of intermediary organization, playing a key role in supporting...  相似文献   
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Macro-level policies frequently transform and reconfigure local livelihood options. While there is a small but growing body of ethnographic work regarding ethnic minority livelihoods in Vietnam’s mountainous borderlands, there is far less research examining the state decrees and policies implemented there and the opinions of state workers who have to apply them. This article starts to address this gap. First, we examine contemporary Vietnamese state legislation regarding upland livelihoods. We focus on the directions found in 82 livelihood-related state decrees, examining their scope and edicts while critiquing what they overlook regarding upland livelihood needs and approaches. Then, from in-depth interviews with state officials in Hà Giang Province, a mountainous upland region with a proportionately large ethnic minority population, we explore the opinions of those charged with the implementation of these decrees. Building on O’Brien’s earlier work on rightful resistance in China, we suggest that a form of “rightful criticism” has emerged among upland state officials, allowing us to reveal the contours of political power in Vietnam’s borderlands. Moreover, we draw attention to the lack of acknowledgement of ethnic diversity in these uplands within policy and official practice.  相似文献   
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In September 2008 the Governor of Pennsylvania, USA, imposed a moratorium on all parole (early conditional) releases from the state prisons, which lasted until March 2009. As a political measure, the moratorium was triggered by a series of violent incidents involving recently released parolees culminating with the killings of several police officers. This paper documents the impact of the moratorium on the parole and correctional processes in the state and discusses its implications for the legitimacy of the two justice agencies affected, the Board of Parole and the Department of Corrections. The paper also describes the research undertaking of the team tasked with conducting the comprehensive review of parole and corrections at the Governor’s request, which circumscribed the lifting of the moratorium on the results of the investigation. In addition to qualitative data, the study employed quantitative methods to investigate through predictive analyses both parole decisions and parolee performance upon release. The challenges of conducting action research in the “spotlight” are also highlighted. The nature of the study and its setting in a large state in the United States should provide a useful illustration of problems and potential approaches to dealing with them that similar crime prevention tasks may face in other jurisdictions around the world relying on conditional release as a means of prison release.  相似文献   
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The present study focused on age at first marriage in Transylvania between 1850 and 1914, a time of both social-economic change and resilient historically entrenched particularities. Based on data extracted from the Historical Population Database of Transylvania we constructed an extensive sample from settlements with a broad range of social-economic characteristics, which allowed for a comparative view into the influence of various factors on marriage timing. We examined in this sense both individual-level co-variates, such as denominational affiliation, migration background, and social-occupational status, as well as broader factors, such as the development level attained by certain settlements and the time frame. We found that the area level of development measured according to a heuristic index was in many cases more decisive than individual characteristics in shaping individuals’ constraints and opportunities on the marriage market. More significantly, the analysis showed that the ways in which the development level worked to transform marriage timing for both men and women could be explained by historically entrenched differences and specificities. At the same time, these patterns in age at first marriage, given by factors such as denomination, might be the result of other largely still invisible factors, for which the variables used are merely imperfect proxies.  相似文献   
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