Automated extraction of DNA from reference samples from various types of biological materials on the Qiagen BioRobot EZ1 Workstation

We have validated and implemented a protocol for DNA extraction from various types of biological materials using a Qiagen BioRobot EZ1 Workstation. The sample materials included whole blood, blood from deceased, buccal cells on Omni swabs and FTA Cards, blood on FTA Cards and cotton swabs, and muscle biopsies. The DNA extraction was validated according to EN/ISO 17025 for the STR kits AmpF?STR^® Identifiler^® and AmpF?STR^® Yfiler^® (Applied Biosystems). Of 298 samples extracted, 11 (4%) did not yield acceptable results. In conclusion, we have demonstrated that extraction of DNA from various types of biological material can be performed quickly and without the use of hazardous chemicals, and that the DNA may be successfully STR typed according to the requirements of forensic genetic investigations accredited according to EN/ISO 17025.     

Misleading congress about drug development: Reply

The review essay by Donald Light about a Congressional Budget Office report on pharmaceutical research and development (R&D) (Light 2007) contains factual errors, leaves the reader uninformed about rebuttal responses to criticisms made in the review about studies of R&D costs, and draws erroneous conclusions about the nature of industry economics.     

It’s a Group Thing: How Voters go to the Polls Together

Political Behavior - Across European Parliament, local and general elections in Denmark between half and three quarters of voters in households with multiple voters cast their vote within a minute...     

Moving the campaign from the front door to the front pocket: field experimental evidence on the effect of phrasing and timing of text messages on voter turnout

Despite the widespread scholarly attention given to get-out-the-vote tactics the recent one and a half decade, few have studied the effect of short text messages (SMS) on voter turnout, and no previous such study has been conducted outside the US. We analyze four SMS experiments with more than 300,000 voters conducted in relation to two elections in Denmark and find intention-to-treat (ITT) effects between 0.33 and 1.82 percentage points with a pooled effect of 0.74 percentage points. Furthermore, we vary the timing and the content of the messages to test existing theories of text messages as mobilization tools. In one experiment, we find messages delivered before Election Day to have a higher effect than those delivered on Election Day, while we find no additional effect of delivering multiple messages. We also vary message content and in general find no significant differences from sending different messages.     

Potential Health Outcome and Vulnerability Indicators of Climate Change for Australia: Evidence for Policy Development

There is a growing need to develop health‐related indicators for climate change to assist in policy, planning, and evaluation of preventive measures. To date, no environmental health indicators of climate change have been developed specifically for Australia. We conducted a review of the Australian literature relevant to climate change health impacts to find out which exposure–response relationships could be readily used as indicators. The bulk of the literature relates to direct health‐related outcomes of extreme heat, and indirect outcomes associated with air pollution and infectious disease agents. Based on this information, evidence‐based indicators were chosen using the modified Driving force‐Pressure‐State‐Exposure‐Effect‐Action framework. Three groups of health outcome indicators are proposed: direct heat related, air pollution related, and climate‐sensitive infectious diseases. Indicators of human vulnerability to these outcomes are also included. The potential usefulness of and barriers to their use are discussed in the context of relevance for policy makers.     

The Asian economic crisis and bureaucratic development: a veto player analysis

The Asian economic crisis ravaged numerous economies in thelate 1990s. Significant social and political disruption followedthe fall in Asian currency prices. The newly industrializedstates of Asia were particularly hard hit, yet some also experiencedswift turnarounds, reaching pre-crisis currency rates and economicoutput. The enduring puzzle of the crisis is the role of bureaucratic-businessties as a background cause of the crisis and determinant ofgovernmental policy responses. In this paper, we adapt Tsebelis'veto player model to include bureaucracy as a formal actor inthe adjustment process. We argue that states that minimizedthe control of developmental bureaucracies over finance anddirect managerial decision-making weakened the institutionalcapacity of bureaucrats to veto adjustment policies, both beforeand after the 1997 crisis. Moreover, we find that a traditionof strategic regulatory guidance is associated with favorableeconomic performance, provided that bureaucrats had subjectedprivate firms or state-owned enterprises to competition (oreven business failure) historically, and where the risks associatedwith financial decisions were not socialized by the state.     

The Myth of Female Credit Discrimination in African Manufacturing

Abstract

We examine credit constraint differentials between male and female manufacturing entrepreneurs using firm data from 16 sub-Saharan Africa countries. Small enterprises owned by female entrepreneurs are less likely to be credit constrained compared to their male counterparts, while this is reversed for medium-sized enterprises. A generalised Oaxaca–Blinder decomposition shows that the gap is predominantly a pure gender effect. We argue that this finding is mainly due to female favouritism in loans to micro and small firms because the gap is reversed for medium-sized enterprises and because we find no sign of superior female entrepreneurial performance in observable indicators.     

The Experience of Parents of Children in Care: The Human Rights Issue

There is a growing body of international literature about birth parents' negative experience of child protection services. This article reviews some of this literature and adds recent Australian materials to it. It is then argued that the over-reliance on “the best interest of the child” construct is the base from which these negative experiences emanate. The argument is that in adopting this construct parents' rights have been removed in favor of children's rights. This violates parents' human rights. Such an approach lacks balance, as human rights are inalienable and cannot be the exclusive property of only one party.     

“Scandinavia’s best-kept secret.”† Tourism promotion,nation-branding,and identity construction in Estonia (with a free guided tour of Tallinn Airport)

This article surveys the official narrative on representation of Estonian identity and Estonianness through the tourism strategy implemented by Estonia from 2007 to 2015. Gathering material from brochures and documents targeting foreigners produced by the Estonian Institute and “Enterprise Estonia” (EAS) and analyzing the logic behind the interior design of Tallinn Airport, we engage with current debates on identity construction in post-Soviet spaces. In particular, we suggest that along with an established body of literature looking at the role of state actors in the construction of identity, studies should consider the role of nontraditional or non-state actors in identifying and promoting identity markers.