Rapid determination of carboxyhemoglobin in blood by Oximeter

Different methods to determine carboxyhemoglobin (COHb) in blood are described in the literature. In our laboratory three methods to analyze COHb in post-mortem blood samples were compared: the spectrophotometric method of Maehly, a gas chromatographic method with a thermal conductivity detector (GC-TCD) and the Oximeter. Several COHb containing blood samples of deceased persons were analyzed. Results of all three methods were comparable for low concentrations (ca. 10% COHb) as well as for high concentrations (ca. 80% COHb) regardless of the viscosity of the blood samples. The advantages of the Oximeter when compared to Maehly's method and GC-TCD are extreme short time of analysis (<1min), very small blood volume required (<0.1ml) and easy handling. In our opinion application of the Oximeter is not limited to analyses of blood samples from living persons (e.g. in clinical toxicology); it can as well be used for the determination of COHb in post-mortem blood samples. Hence it is a useful and time saving tool in forensic toxicology.     

A comparison of adjustment methods to test the robustness of an STR DNA database comprised of 24 European populations

An aim of the European Network of Forensic Science Institutes (ENFSI) is to produce a DNA database of second generation multiplex (SGM) STR profiles that is representative of the resident cosmopolitan populations. To achieve this, data were collected from 24 different populations. All of the data were combined to form one database of 5700 profiles from which allele proportions were calculated. The robustness of this combined European database was tested by estimating parameter d for every DNA profile, where d=log(10)(Pm(c)/Pm(E)) Pm(c) is the match probability of the profile calculated from its cognate database and Pm(E) is the match probability of the combined European database. Overall there was a small tendency for Pm(c)>Pm(E) primarily because of sampling bias. This bias was removed by the simple expediency of applying an adjustment factor to the calculation of Pm(E). These were selected from the Balding size bias correction, the Balding and Nichols Fst correction, a minimum allele proportion (between 0.01 and 0.02), an upper bound of a 95% confidence interval (CI) and a lower bound on the genotype match probability. It was demonstrated that a single European database is a feasible proposition. A combination of different adjustment methods can be used to ensure that the result is conservative relative to the cognate database, and their effect measured by parameter d.     

Statistical analysis of barefoot impressions

Comparison of the shapes of barefoot impressions from an individual with footprints or shoes linked to a crime may be useful as a means of including or excluding that individual as possibly being at the scene of a crime. The question of the distinguishability of a person's barefoot print arises frequently. This study indicates that measurements taken from the outlines of inked footprint impressions show a great degree of variability between donors and a great degree of similarity for multiple impressions taken from the same donor. The normality of the set of measurements on footprint outlines that we have selected for this study is confirmed. A statistical justification for the use of the product rule on individual statistical precisions is developed.     

Interpreting the Rule of Law

International Journal for the Semiotics of Law - Revue internationale de Sémiotique juridique -     

Benefactors or Beneficiary—The Role of Industry in the Support of University Research Equipment

This paper examines the role of industry in the support of academic infrastructure, in particular university research equipment. Although the United Kingdom provides the framework for discussion the described situation should be a familiar one in most countries. The argument is constructed around the perceptions, opinions and positions of universities, government and industry. Drawing on results from a survey of academic departments the equipment situation at UK universities is outlined. Following that the position of the Government attempting to attract industrial support for university research equipment is discussed. And finally, industry's views of where the demarcation between public and private responsibility lies are presented.     

An appreciation of Alvey Adee

Alvey Augustus Adee (1842-1924) spent a diplomatic apprenticeship in the American legation at Madrid. In 1877, he entered the State Department in Washington and served there until his death. Adee spent almost four decades as the Second Assistant Secretary of State, the closest the United States has come to having a Permanent Under-Secretary. He managed American diplomacy in crises as well as quieter times, with an unparalleled expertise.     

A Prescription Rejected: Market Solutions to Problems of Public Sector Governance

The New Public Management includes the idea of incorporating market mechanisms in public sector governance. In the Danish case, market reforms have scarcely been used; private sector supplies of public services have not increased during the last decade. The lack of success of market reform in Denmark is explained by the strong institutions of traditional public sector governance operating at the micro-level. Formal and informal hierarchy and formal and informal corporatism hold a strong grip on public sector governance. The very decentralized structure of the Danish public sector decreases the importance of central government in terms of reform strategies. Strong interests and institutional constraints keep reforms in the Danish public sector within a hierarchical mode of governance.     

From plan to network: Urban elites and the post-communist organisational state in Russia

Abstract. This article uses the results from formal network analysis to test hypotheses about the character of Russia's post-communist transition, taking decision-making elites at the sub-national level as the unit of analysis. From the transition literature, the hypothesis generated is that city politics retains elements of its pre-democratic structure; from the urban regime theory, the hypothesis generated is that the elites' structure will show elements of convergence to a Western type, with the prominence of actors from the private sector. The data is drawn from a survey of elites in one city, Novosibirsk, undertaken in 1997. The results show that the membership and structure of the network has some similar characteristics to a Western city. Rather than being purely dominated by bureaucratic elites, the private sector plays a role. The private sector actors are grouped with the public sector actors, though they are not, however, equal partners to the networks as its members do not appear among the most networked in the city. We conclude that the legacy of the past may not be as much a constraint as the transition literature supposes.