Neonatal death following clozapine self-poisoning in late pregnancy: an unusual case report

The report presents a fatal poisoning of a neonate occurring in the final stage of gestational life and evoked by his mother, who, while 9 months pregnant, took a toxic dose of clozapine aiming at committing suicide. She was also severely poisoned, but ultimately was saved. The woman had been taking the medication due to schizophrenia and depression prior to conception, and the discontinuation of the drug in the course of pregnancy increased the risk of the woman attempting suicide. In the course of comprehensive toxicological analysis based on the developed analytical procedure with the use of LC-APCI-MS, clozapine and its two metabolites, norclozapine and clozapine-N-oxide, were determined in postmortem blood, liver and kidney in concentrations explaining the death of the neonate. The interpretation of the above-described case is complex and--apart from toxicological aspects--also involves issues associated with psychiatry, pharmacotherapy in pregnancy and medicolegal problems.     

Identification of common impurities present in the synthetic routes leading to 4-methylthioamphetamine (4-MTA). Part II: Reductive amination and nitropropene route

In this paper the by-products arising during the synthesis of 4-methylthioamphetamine (4-MTA) by LiAlH(4) reduction of 1-(4-methylthiophenyl)-2-nitropropene (nitropropene route) and reductive amination of 4-methylthiophenyl-2-propanone in the presence of NaCNBH(4) are investigated. The identification of 4-methylthio derivatives of N-(β-phenylisopropyl)benzaldimine, 4-methylthio derivative of N-(β-phenylisopropyl)benzyl methyl ketimine, 1-(4-methylthiophenyl)-N-(4-methylthiobenzyl)-2-propanamine, (RS) and (SS/RR)-N,N-di-[β-(4-methylthiophenyl)isopropyl]amine, 4-methylthiobenzyl ether and methylthiobenzoic acid methyl ester as most prominent impurities in crude 4-MTA synthesised by reductive amination of 4-methylthiophenyl-2-propanone, is reported. Methylthio derivatives of 2-methyl-3-phenylaziridine, 2-benzylaziridine, and 4-methylthio derivative of BMK oxime as route-specific markers of nitropropene route leading to 4-MTA, were also characterized. The identity of these compounds was confirmed by their independent synthesis.     

Identification and characterization of 2,5-dimethoxy-4-nitro-β-phenethylamine (2C-N) - A new member of 2C-series of designer drug

The online sale of psychoactive substances, including hallucinogens, is becoming a serious problem in many countries. This paper presents and discusses the mass spectrometric, infrared spectroscopic and nuclear magnetic resonance spectroscopic data of 2,5-dimethoxy-4-nitro-β-phenethylamine (2C-N), which was identified in a powder sample seized by the authorities in 2011 in Poland. The molecular mass of 2C-N (226.0954amu) was confirmed in the LC/ESI-QTOFMS experiment. The molecular ion was also observed in the GC-EI/MS spectrum. A characteristic set of ions for the parent substance was found using both chromatographic methods, and when derivatization with trifuluoroacetic anhydride (TFAA) was applied. Two broad dominant bands at 1520cm(-1) and 1342/1322cm(-1), observed in the FTIR spectrum of 2C-N, originated from the nitro group. NMR spectroscopy helped unequivocal elucidation of the structure. The applied identification procedure proved to be a powerful tool to determine the structure of a new designer drug.     

Remarks on the Normativity of International Legal Rules and Global Constitutionalism

The article reflects on the possibility of conceptualising the complex problem of the normativity of international legal rules, including in particular the phenomenon of “relative normativity.” The author utilises the critical potential of Ronald Dworkin's proposal for a new philosophy of international law to reflect on the classical accounts explaining normativity of international law. By building on Dworkin's argument, the author argues for a constitutional account of international law. The far‐reaching constitutional proposals may provide a more complex and coherent set of possible rationalisations of international legal rules. International law is in great need of a comprehensive theory that could better explain its normative character as well as its sources, and it is argued that international constitutionalism has the potential to serve this purpose.     

EU–China Regional Policy Dialogue: Unpacking the Mechanisms of an Unlikely Policy Transfer

Abstract

This article investigates EU–China dialogue on regional policy, a puzzling exercise in policy transfer because such policy is by its nature inward-oriented and the intricacies of regional development imply uncertainty about its effects in different contexts. The article sheds light on the reasons of both sides for engaging in this unlikely policy learning effort and identifies its actors and mechanisms. It also critically assesses this process, stressing its one-way nature and the active role of the EU as a ‘policy-sender’, in contrast to most policy transfer literature citing demands by the policy-recipient as the predominant reason to engage in such cooperation.     

“Scandinavia’s best-kept secret.”† Tourism promotion,nation-branding,and identity construction in Estonia (with a free guided tour of Tallinn Airport)

This article surveys the official narrative on representation of Estonian identity and Estonianness through the tourism strategy implemented by Estonia from 2007 to 2015. Gathering material from brochures and documents targeting foreigners produced by the Estonian Institute and “Enterprise Estonia” (EAS) and analyzing the logic behind the interior design of Tallinn Airport, we engage with current debates on identity construction in post-Soviet spaces. In particular, we suggest that along with an established body of literature looking at the role of state actors in the construction of identity, studies should consider the role of nontraditional or non-state actors in identifying and promoting identity markers.     

Penetration Depth of Projectiles Fired from a Replica of Colt Navy of 1851 in 20% Gelatin Blocks Correlated with Fatal Injuries Assessed in an Autopsy of a 78‐Year‐Old Man

Pursuant to the Polish Weapons and Ammunitions Law, muzzle‐loading black powder weapons, manufactured before 1885, or their replicas, as well as suitable projectiles, can be possessed legally without registration and special licenses. The aim of the study was to assess the penetration depth of projectiles fired from a black powder weapon, replica of Colt Navy of 1851, in 20% gelatin blocks and to compare the obtained results with the actual injuries found on autopsy of a 78‐year‐old man who had committed suicide. In the experiments, we used the black powder weapon and ammunitions, as well as gelatin blocks serving as a soft tissue model. We ascertained that solid spherical projectiles fired from black powder weapons cause extensive injuries, especially in the initial segment of the wound canal. Additionally, based on the presence and location of the wad in the wound canal, the distance from which the shot was fired can be determined.     

A cooperative Peru: Is centralisation of cooperatives better for local development?

Research shows that some agricultural cooperatives implement development projects in their local communities. What remains to be explained is why certain cooperatives pursue local development while others do not. Through a comparison of coffee cooperatives in two regions of Peru, this study examines the implications of a regional cooperative for local development. The creation of a regional cooperative leads to a concentration of resources and a decrease in the need and ability of local cooperatives to pursue independent development projects. At the same time, it allows for more equal access to those resources and to the benefits of cooperative-led development projects.     

Should gains from criminal knowledge be forfeited?

Crime, Law and Social Change - Nobody should profit from crime; this fundamental moral principle is uncontroversial. At the level of public declaration, few people are likely to disagree with this...     

The Application of Missing Data Estimation Models to the Problem of Unknown Victim/Offender Relationships in Homicide Cases

Homicide cases suffer from substantial levels of missing data, a problem largely ignored by criminological researchers. The present research seeks to address this problem by imputing values for unknown victim/offender relationships using the EM algorithm. The analysis is carried out first using homicide data from the Los Angeles Police Department (1994-1998), and then compared with imputations using homicide data for Chicago (1991-1995), using a variety of predictor variables to assess the extent to which they influence the assignment of cases to the various relationship categories. The findings indicate that, contrary to popular belief, many of the unknown cases likely involve intimate partners, other family, and friends/acquaintances. However, they disproportionately involve strangers. Yet even after imputations, stranger homicides do not increase more than approximately 5%. The paper addresses the issue of whether data on victim/offender relationships can be considered missing at random (MAR), and the im-plications of the current findings for both existing and future research on homicide.