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844.
Gamma hydroxybutyric acid (GHB) concentrations in humans and factors affecting endogenous production
Elliott SP 《Forensic science international》2003,133(1-2):9-16
The endogenous nature of the drug of abuse gamma hydroxybutyric acid (GHB) has caused various interpretative problems for toxicologists. In order to obtain data for the presence of endogenous GHB in humans and to investigate any factors that may affect this, a volunteer study was undertaken. The GHB concentrations in 119 urine specimens from GHB-free subjects and 25 urine specimens submitted for toxicological analysis showed maximal urinary GHB concentrations of 3mg/l. Analysis of 15 plasma specimens submitted for toxicological analysis detected no measurable GHB (less than 2.5mg/l). Studies in a male and female volunteer in which different dietary food groups were ingested at weekly intervals, showed significant creatinine-independent intra-individual fluctuation with overall urine GHB concentrations between 0 and 2.55, and 0 and 2.74mg/l, respectively. Urinary concentrations did not appear to be affected by the particular dietary groups studied.The concentrations measured by gas chromatography with flame ionisation detection (GC-FID) and gas chromatography with mass spectrometry (GC-MS) lend further support to the proposed urinary and plasma interpretative cut-offs of 10 and 4mg/l, respectively, where below this it is not possible to determine whether any GHB detected is endogenous or exogenous in nature. 相似文献
845.
Simon C Moore Rochelle HarrisCynthia McDougall Jane Clarbour 《Journal of criminal justice》2003,31(6):497
Although the majority of the general population decides not to offend, a significant proportion decides otherwise. The research presented in this article explores whether offenders reason in manners that are comparable with a non-offender population, or if their decision to offend may be a consequence of inappropriate reasoning strategies. Psychologists have observed systematic deviations from logical predictions of reasoning behavior on a variety of tasks and that content specific information can have marked effects on reasoning behavior. Established reasoning tasks were adapted for use in a crime specific context to examine whether such biases were apparent in an offender population. Moreover, given a paucity of research into gender differences, the research conducted balanced for gender in a methodologically rigorous design. Data suggested that reasoning biases found with non-offender populations extended to an offender population and some interactions by gender and by offender group were noted. Implications of the results are discussed with suggestions on how the research may be extended and implications for policy. 相似文献
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848.
Rosleenda B Mohamed Ali Simon A Moss Kate Barrelle Peter Lentini 《Journal of Police and Criminal Psychology》2017,32(1):43-55
To redress the scourge of violent extremism, an array of policies, programs, and practices have been implemented. Yet, these initiatives could sometimes conflict with the preferences of individuals who may be susceptible to radicalization. To illustrate, some initiatives might challenge the values of these individuals. The degree to which these individuals feel significant or important might thus decrease—a decrease that has been shown to rouse the pursuit of violent radicalization. To prevent this complication, two studies were designed to uncover programs, policies, or practices that align to the preferences of people who may be more susceptible than average to violent radicalization. In Study 1, three individuals who had been charged with crimes related to terrorism, but had since relinquished extremism, were asked to suggest initiatives they feel could prevent violent radicalization in Australian Muslims. Similarly, in the second study, young Australian Muslim adults who rejected extremist ideologies were asked the same question. The participants advocated initiatives that foster tolerance towards diverse perspectives, inspire individuals to trust their values and intuition, encourage civic engagement, improve the credibility of imams, and enable people to derive strength from their community. A review of previous literature indicates that many of these initiatives might not only resonate with the preferences of individuals who may be vulnerable to violent extremism but could also foster a sense of significance and meaning in life—an experience that tends to prevent radicalization. 相似文献
849.
Simon A. Price 《International Review of Law, Computers & Technology》1999,13(2):95-126
As the move toward the wider regulation of cryptography, both within the United Kingdom and elsewhere, becomes increasingly irresistible, the degree of understanding afforded to cryptography at the level of policy formation remains underdeveloped, ambiguous and, at times, misleading. One corollary of such solicitude is that a number of the most important and pervasive legal issues that flow naturally from the widespread availability of cryptography remain largely unexplored. This article attempts to remedy these deficiencies. It begins by offering a brief historical perspective before progressing to consider more substantive issues such as cryptography's aims, power, limitations, effectiveness and future. Ignoring, to a large extent, issues of law enforcement, and focusing, in particular, upon both the law of data protection, and, to a lesser extent, the general law of obligations in the United Kingdom, this article argues that the decision to utilise cryptography will not simply prove a matter of choice, preference or expediency, but of legal and commercial necessity in order to avoid the potential imposition of widespread indeterminate liability. 相似文献
850.
John Griffiths 《European Journal of Law and Economics》1995,2(4):285-299
Two approaches to the problem of explaining social order are compared: the rational choice approach (as represented in Coleman'sFoundations of Social Theory) and the normative or social control approach, in which rules and rule-following play the central role. Considered in terms of Coleman's own criteria for social theory, only the social control approach seems plausible. In particular, the rational choice approach is circular in that it necessarily presupposes the existence of rules and rule-following, while its pretense is to be able to explain social order in non-normative terms. The social control approach accounts for social order in terms of the existence of social rules and the innate capacity of human beings to learn to follow such rules. 相似文献