Morphine to codeine concentration ratio in blood and urine as a marker of illicit heroin use in forensic autopsy samples

A morphine to codeine ratio greater than unity (M/C>1) has been suggested as an indicator of heroin use in living individuals. The aim of this study was to examine the morphine to codeine ratio in a large population (N=2438) of forensically examined autopsy cases positive for 6-monoacetylmorphine (6-MAM) and/or morphine in blood and/or urine. Blood and urine concentrations of 6-MAM, morphine and codeine were examined using GC-MS and LC-MS/MS methods. In 6-MAM positive samples, the M/C ratio was greater than unity in 98% (N=917) of the blood samples and 96% (N=665) of the urine samples. Stratification of 6-MAM negative cases by M/C above or below unity revealed similarities in morphine and codeine concentrations in cases where M/C>1 and 6-MAM positive cases. Median blood and urine morphine concentrations were 8-10 times greater than codeine for both groups. Similarly to 6-MAM positive cases, 25-44 year-old men prevailed in the M/C>1 group. In comparison to cases where M/C ≤ 1, the M/C ratio was a hundred times higher in both 6-MAM positive and M/C>1 cases. The range of morphine concentration between the lowest and the highest quintile of codeine in M/C>1 cases was similar to that in 6-MAM positive cases. This range was much higher than for M/C ≤ 1 cases. Moreover, linear regression analyses, adjusted for age and gender, revealed a strong positive association between morphine and codeine in 6-MAM positive and M/C>1 cases. The M/C ratio appeared to be a good marker of heroin use in post-mortem cases. Both blood and urine M/C>1 can be used to separate heroin users from other cases positive for morphine and codeine.     

Flunitrazepam: psychomotor impairment, agitation and paradoxical reactions

Benzodiazepines are sedatives used for anxiolysis, hypnosis, muscle relaxation and the treatment of epilepsy. Paradoxical reactions including agitation, talkativeness, confusion, disinhibition, aggression, violent behavior and loss of impulse control may, however, occur in some subjects. It has been claimed that high doses of flunitrazepam may cause aggression on a more regular basis in all individuals. The present study makes use of a Norwegian forensic toxicological database containing analytical results from drivers suspected of driving under the influence and suspects of violent crime to analyze the relationship between behavior and blood flunitrazepam concentration. Four-hundred and fifteen cases of drivers suspected of driving under the influence and seven cases of suspects of violent crime were studied. These selected cases had flunitrazepam as the only drug in blood samples and had been evaluated by a clinical test for impairment (CTI) performed by a police physician at the time of blood sampling. The impaired drivers had higher blood flunitrazepam concentrations than the not impaired drivers. Multivariate analysis revealed that both blood flunitrazepam concentration and age of the suspected drivers had independent impact on impairment, indicating tolerance with age. Most of the effects measured were sedative effects of flunitrazepam and these effects were related to flunitrazepam level. Possible paradoxical reactions were observed in a subgroup of 23 individuals (6%), but these reactions did not relate to blood flunitrazepam concentration. The suspects of violent crime showed similar degree impairment and had not more paradoxical reactions than the suspected drugged drivers. The findings were in agreement with other research that claims paradoxical reactions should be viewed as a reaction in certain individuals, and does not support the notion that flunitrazepam in high concentration produces aggression in all individuals taking the drug.     

Civil Society under the Law ‘On Foreign Agents’: NGO Strategies and Network Transformation

Abstract

This essay analyses how the ‘foreign agent’ law has been interpreted and implemented by the Russian authorities and examines diverse NGO survival strategies in response to the ‘foreign agent’ label. The foreign agent law has disrupted and transformed resource mobilisation strategies and transnational NGO networks. Based on qualitative research on environmental NGOs, we offer a typology of NGO responses to the foreign agent law, providing examples to show how the organisations attempt to ensure their survival.     

Multicultural Pedagogy Development in Modern Education

Although there is a growing interest in the influence of multicultural issues in education, there is still a lack of theoretically well-grounded comparative analyses of educational systems. Topics such as problems and prospects involved in the development of multicultural pedagogy are broadly discussed, but often suffer from an insufficient number of empirical and comparative studies. The lack of systemic or unified research in the field of multicultural education has reduced multicultural pedagogy within education to the simple implementation of individual training courses. As a result, multicultural pedagogy is generally oriented only toward the needs of a single country, rather than toward a system of multicultural interests that takes into account the interests of multiple countries. As a result, we must develop methods that will enable the realization of true multicultural pedagogy. The leading objective should be, firstly, the consideration of the individual as a subject of culture in a multicultural environment with a goal to determine the significance of the formation of an individual＇s multicultural qualities; secondly, the development of an integrative approach. Comparative studies are taking the lead in addressing this goal and recommending specific steps to incorporate multicultural pedagogy more systematically into an existing education system in every country. This paper addresses these problems by discussing theoretical questions behind the development of the ideological basis of multicultural pedagogy.     

Part III. Interstate Agreements on Cooperation Against Terrorism : Treaty Concerning Cooperation Between Members of the Commonwealth of Independent States in the Struggle Against Terrorism

The authors of Federal Law No. 131 "On the General Principles of the Organization of Local Self-Government in the Russian Federation" knew what they were doing when they provided a three-year "transition period" for their creation. The law entered into force in its full measure in far fewer than all of the regions of the country and there is plenty of confusion. And the situation with authority and money among the bodies of local self-government recalls the well-known old anecdote concerning the fate of money under communism: some have it and some do not.     

Left Behind: Boris E. Skvirsky and the Chita Delegation at the Washington Conference, 1921–22

Although the story of the role of the Special Trade Delegation of the Russian short-lived Far Eastern Republic during the Washington Conference on Naval Disarmament of 1921–22, seems to be well-known from its many Western accounts published since 1922, a recent search in the records of the Russian Communist Party has uncovered many hitherto unknown or obscure details that shed the light on the fascinating intelligence origins of the secret documentation, which the delegation made public during the conference. Particularly, the Russian records indicate the central role of one of the delegates, Boris Skvirsky, who would be left behind in the United States to become the Soviet unofficial representative and back channel during the years of non-recognition of the Soviet Union by the United States.     

Sustainable Use of Wildlife Indicators: Formation and Implementation Issues in the Russian Federation

The article explores the legal category of “sustainable use of wildlife” as a model for the behavior of subjects in a legal relationship in the sphere of wildlife use and as a fundamental principle aimed at preserving and restoring the entire biodiversity of wildlife. Based on the analysis of certain legislative provisions concerning wildlife and law enforcement practice, the author justifies the conclusion that there are no criteria and indicators for sustainable use of wildlife in the Russian Federation. Indicators for sustainable use of wildlife, proposed by the author, are an important mechanism for monitoring and influencing the system of sustainable wildlife management, the main tool in assessing the effectiveness of the funds used and the levels of achievement. In the author's opinion, these criteria and indicators would be useful for the development of national programs for the sustainable use of wildlife, providing incentives for the transition to sustainable use. Creating mechanisms of this kind could enhance dialogue with the public and involve them in the process of sustainable use of wildlife objects, with a view to balancing between economic, environmental and social interests.